Determination of puerarin in rabbit aqueous humor by liquid chromatography tandem mass spectrometry using microdialysis sampling after topical administration of puerarin PAMAM dendrimer complex

Wang, Wenyan; Chen, Yao; Shao, Yu-Feng; Mu, Hongjie; Sun, Kaoxiang

doi:10.1016/j.jpba.2011.07.017

Cited by 22 publications

(15 citation statements)

References 14 publications

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“…The complex enhanced by 1.3‐, 2.0‐ and 2.7‐fold the C max , AUC and T 1/2 , respectively, compared with puerarin solution. In spite of the satisfactory results, more studies need to be conducted to demonstrate the influence of different generations of PAMAMs with different surface groups on the ocular drug permeation and bioavailability …”

Section: Delivery Systemsmentioning

confidence: 99%

“…In spite of the satisfactory results, more studies need to be conducted to demonstrate the influence of different generations of PAMAMs with different surface groups on the ocular drug permeation and bioavailability. [90] Another important promising application of dendrimers for topical ocular drug delivery is related to gene therapy. Free siRNA may undergo degradation in the presence of endogenous enzymes.…”

Section: Dendrimersmentioning

confidence: 99%

“…[60,62] Dendrimer Increased drug residence time, corneal permeation and bioavailability relative to free drug in solution. [88][89][90] Iontophoresis Improved drug bioavailability to both the anterior and posterior segments of the eye. Generally, transscleral iontophoresis is more suitable for drug delivery to the posterior segment whereas application through the cornea is more effective for the anterior segment.…”

Section: Microemulsionsmentioning

confidence: 99%

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Topical delivery of ocular therapeutics: carrier systems and physical methods

Souza

Dias

Pereira

et al. 2013

Journal of Pharmacy and Pharmacology

114

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Objective The basic concepts, major mechanisms, technological developments and advantages of the topical application of lipid-based systems (microemulsions, nanoemulsions, liposomes and solid lipid nanoparticles), polymeric systems (hydrogels, contact lenses, polymeric nanoparticles and dendrimers) and physical methods (iontophoresis and sonophoresis) will be reviewed. Key findings Although very convenient for patients, topical administration of conventional drug formulations for the treatment of eye diseases requires high drug doses, frequent administration and rarely provides high drug bioavailability. Thus, strategies to improve the efficacy of topical treatments have been extensively investigated. In general, the majority of the successful delivery systems are present on the ocular surface over an extended period of time, and these systems typically improve drug bioavailability in the anterior chamber whereas the physical methods facilitate drug penetration over a very short period of time through ocular barriers, such as the cornea and sclera. Summary Although in the early stages, the combination of these delivery systems with physical methods would appear to be a promising tool to decrease the dose and frequency of administration; thereby, patient compliance and treatment efficacy will be improved.

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Section: Delivery Systemsmentioning

confidence: 99%

Section: Dendrimersmentioning

confidence: 99%

Section: Microemulsionsmentioning

confidence: 99%

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Topical delivery of ocular therapeutics: carrier systems and physical methods

Souza

Dias

Pereira

et al. 2013

Journal of Pharmacy and Pharmacology

114

View full text Add to dashboard Cite

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“…In addition, PAMAM G4 and G5 with amine or carboxyl groups increased the half-life of puerarin in rabbit eyes [24]; and the pharmacokinetic properties of puerarin were improved in aqueous humor when it was complexed with PAMAM G3 [25]. Despite these satisfactory results, the effect of iontophoresis on PAMAM ocular penetration has never been studied.…”

Section: Introductionmentioning

confidence: 99%

Transcorneal iontophoresis of dendrimers: PAMAM corneal penetration and dexamethasone delivery

Souza

Dias

Silva

et al. 2015

Journal of Controlled Release

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“…45 Cationic nanoparticles have shown efficacy as permeation enhancers for transepithelial drug delivery. 46–48 PAMAM dendrimers are strongly cationic on the full generations when amine terminated (G3.0, G4.0, G5.0, etc.…”

Section: Topical Formulationsmentioning

confidence: 99%

Dendrimers for ocular drug delivery

Lancina

Yang

2017

Can. J. Chem.

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Existing methods of administering ocular drugs are limited in either their safety or efficiency. Nanomedicine therapies have the potential to address this deficiency by creating vehicles that can control drug biodistribution. Dendrimers are synthetic polymeric nanoparticles with a unique highly organized branching structure. In recent years, promising results using dendrimer vehicles to deliver ocular drugs through different routes of administration have been reported. In this review, we briefly summarize these results with emphasis on the dendrimer modifications used to target different ocular structures.

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Determination of puerarin in rabbit aqueous humor by liquid chromatography tandem mass spectrometry using microdialysis sampling after topical administration of puerarin PAMAM dendrimer complex

Cited by 22 publications

References 14 publications

Topical delivery of ocular therapeutics: carrier systems and physical methods

Topical delivery of ocular therapeutics: carrier systems and physical methods

Transcorneal iontophoresis of dendrimers: PAMAM corneal penetration and dexamethasone delivery

Dendrimers for ocular drug delivery

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