Determination of Protonation Constants of Viral Inhibitor, Aurintricarboxylic Acid in SDS and CTAB Micellar Media: A Potentiometric Study

Abstract

Protonation constants of a viral inhibitor, aurintricarboxylic acid were determined using potentiometric method of data acquisition followed by chemometric modelling methods of analysis in the presence of two different kinds of micellar media, CTAB, a cationic micelle and SDS, an anionic micelle. MINIQUAD75 program was used for the determination of the plausible species and their corresponding formation constants at 303 ± 0.1 K and 0.01 M ionic strength. Five formation constants were identified corresponding to five ionizable hydrogens. Species concentration distribution diagrams were generated using Origin software. Best-fit chemical models were selected on the basis of statistical parameters like standard deviation (SD), U (sum of the squares of the residuals in mass balance equations) and chi-square test. It was found that the formation constants are lower in CTAB micellar medium while there is no significant change in the presence of SDS compared to aqueous medium.

The Electrostatic and Non-Electrostatic Interaction Affect on Acidity Constants of Bromocresol Purple in Aqueous Ethanolic Media

“…The UV-Vis spectrum of (1.85 ⋅ 10 − 5 M) bromocresol purple in aqueous ethanol at various pH values was recorded. Sample of this spectrum at different pH values within the pH range (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) in aqueous ethanol mixtures are shown in Fig. 2.…”

“…For various acid-base indicators, which have different functional groups, there is a marked spectral change with the pH variation of the solution. [5][6][7] The electronic spectral data are used to calculate the acidity constant of the indicators under investigation. The values of the acidity constant are estimated at 25°C by the dependence between the optical density and thus -log [H + ].…”

The Electrostatic and Non-Electrostatic Interaction Affect on Acidity Constants of Bromocresol Purple in Aqueous Ethanolic Media

“…The UV-Vis spectrum of (1.85 ⋅ 10 − 5 M) bromocresol purple in aqueous ethanol at various pH values was recorded. Sample of this spectrum at different pH values within the pH range (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) in aqueous ethanol mixtures are shown in Fig. 2.…”

Determination of Aurintricarboxylic Acid (A Viral Inhibitor) Using Mixed Micellar Cloud Point Extraction Procedures

“…and potent inhibitor of protein-nucleic acid interactions [1]. According to molecular docking-based virtual screening [2] shows that ATCA inhibits the replications of viruses such as SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), causing severe acute respiratory syndrome [3,4].…”