Determination of Pralsetinib in Human Plasma and Cerebrospinal Fluid for Therapeutic
Drug Monitoring by Ultra-performance Liquid Chromatography-Tandem Mass
Spectrometry (UPLC-MS/MS)
Zichen Zhao,
Qianlun Pu,
Tonglin Sun
et al.
Abstract:Background:
Ultra-performance Liquid Chromatography-tandem Mass Spectrometry (UPLC-MS/MS)
is widely used for concentration detection of many Tyrosine Kinase Inhibitors (TKIs), including afatinib, crizotinib, and osimertinib. In order to analyze whether pralsetinib takes effect in Rearranged during Transfection
(RET)-positive patients with central nervous system metastasis, we aimed to develop a method for the detection
of pralsetinib concentrations in human plasma and Cerebrospinal Fluid (CSF) by UPLC-MS/MS.
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