Determination of Potential Migrants in Polycarbonate Containers Used for Microwave Ovens by High-Performance Liquid Chromatography with Ultraviolet and Fluorescence Detection

Abstract

The determination of several compounds present in a commercial polycarbonate container intended to be used in microwave ovens which could be considered as potential migrants has been carried out by reversed-phase high-performance liquid chromatography (HPLC) with both ultraviolet (UV) and fluorescence detectors. Total dissolution with dichloromethane and polymer reprecipitation with methanol have been used to evaluate 100% potential migration as the worst case. The extract consisted of a complex mixture containing monomers, oligomers, UV stabilizers, antioxidants, degradation products, and other additives. Phenol, Bisphenol A, 2,4-di-tert-butylphenol, Cyasorb UV5411, bis(2-ethylhexylphthalate), Irganox 1076, and Irgafos 168 were identified by both retention times and fluorescence-to-UV ratios. Additional confirmation was achieved by HPLC with diode array detection and gas chromatography-mass spectrometry. Recovery percentages were in the range of 73.8-94.4%, the lowest one being for the antioxidant Irgafos 168 due to its transformation into the phosphate form and 2,4-di-tert-butylphenol. The concentrations of the studied analytes present in the polycarbonate container ranged between 0.9 and 240 microg.g(-)(1). The total dissolution conditions that may affect the final concentration of analytes, mainly Bisphenol A, are discussed.

Rapid confirmatory method for the determination of sixteen synthetic growth promoters and bisphenol A in bovine milk using dispersive solid-phase extraction and liquid chromatography–tandem mass spectrometry

“…Polycarbonate plastics are used in food and drink packaging; resins are used as lacquers to coat metal products such as food cans, bottle tops and milk containers. The migration of BPA from epoxy coated can surfaces, polycarbonate plastics, and PVC products into food has been reported [23][24][25][26][27][28][29][30][31][32][33]. Adverse effects due to exposure to this substance are similar to those detailed earlier for steroid type growth promoters.…”

<i>Cinnamomum loureirii</i> Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice

“…[20][21][22] Of note, BP has been widely used as a raw material for phosphite antioxidants and as an intermediate for the preparation of ultraviolet stabilizers as well. 23) According to previous reports, BP is an antioxidant with remarkable cytotoxic activity against cancer cells, 24,25) and it has been shown to decrease the degree of low-density lipoprotein (LDL)-oxidation. 26) Moreover, BP was reported to be the active compound in the ethanol extract of Ipomoea batatas that was shown to be protective against Aβ-induced neurotoxicity.…”

Sample clean-up with sol–gel enzyme and immunoaffinity columns for the determination of bisphenol A in human urine

“…In addition, BPA is used to manufacture epoxy resins which are applied as linings in food and beverage cans. Several studies have already indicated leakage of BPA traces from polycarbonate containers [7,8] and epoxy linings in food [9][10][11][12]. * Corresponding author.…”