Determination of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in Brazilian cow milk

Rocha, Dayse A.M.; Torres, João Paulo Machado; Reichel, Klaus; Novotny, E. H.; Estrella, Leonardo Fontes; Medeiros, Rebeca O.; Netto, Annibal Duarte Pereira

doi:10.1016/j.scitotenv.2016.07.179

Cited by 14 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reported levels of pesticides and/or persistent organic pollutants in milk vary depending on geographic region, year of survey, and chemical classes analyzed. 1−6 The distribution of a chemical among a variety of milk products is dependent on its physicochemical properties, the milk processing methods used, and the final milk products produced.…”

Section: Introductionmentioning

confidence: 99%

“…Pesticides or environmental contaminants of milk or milk products may occur after the consumption of contaminated feed, exposure to contaminated facilities, and/or contamination during milk handling, transport, and/or processing. Reported levels of pesticides and/or persistent organic pollutants in milk vary depending on geographic region, year of survey, and chemical classes analyzed. − The distribution of a chemical among a variety of milk products is dependent on its physicochemical properties, the milk processing methods used, and the final milk products produced.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Distribution of Chemical Residues among Fat, Skim, Curd, Whey, and Protein Fractions in Fortified, Pasteurized Milk

et al. 2018

View full text Add to dashboard Cite

The distribution of 12 environmental contaminants or metabolites with diverse polarities (2,2′,4,4′,5-pentabromodiphenyl ether; bisphenol A; estrone; glyphosate; β-hexabromocyclododecane; imidacloprid; 2,3′,4,4′,5-pentachlorobiphenyl; 3′-methylsulfone 2,2′,4,5,5′-pentachlorobiphenyl; 1,2,7,8-tetrachlorodibenzo- p -dioxin; 2-hydroxy-1,3,7,8-tetrachlorodibenzo- p -dioxin; tetrabromobisphenol A; and triclocarban) among skim milk, fat, curd, whey, whey retentate, and whey permeate was characterized. Analysis of these compounds along with 15 drugs previously studied provided a robust linear model predicting the distribution between skim and fat and the chemical’s lipophilicity (log P , r 2 = 0.71; log D , r 2 = 0.79). Similarly, distribution between curd and whey was correlated with lipophilicity (log P , r 2 = 0.63; log D , r 2 = 0.73). Phenolic compounds had less predictable distribution patterns based on their lipophilicities. Within the whey fraction, chemicals with greater lipophilicity are associated with whey proteins more than hydrophilic chemicals. The resultant model could help predict the potential distribution of chemical contaminants among milk products in cow milk, if present.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distribution of Chemical Residues among Fat, Skim, Curd, Whey, and Protein Fractions in Fortified, Pasteurized Milk

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The broad objective of the present study was to elucidate the effect of the reported concentrations of dioxins present in the milk by using 3D cultured primary buffalo hepatocytes as a model culture system. The data from different countries showed that the concentrations of dioxins in the milk were in the range 0.023–26.46 pg/mL. − Interestingly, the toxic effect of dioxins in the milk in this range of concentrations is not well established. The 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD), a polychlorinated dibenzo dioxin, is considered as a model dioxin in many studies.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dioxins in Milk on the 3D Cultured Primary Buffalo Hepatocyte Model System

Goud

Pandey

Singh

et al. 2019

J. Agric. Food Chem.

View full text Add to dashboard Cite

Cow and human milk have been reported to contain dioxins ranging from 0.023 to 26.46 and 0.88 to 19 pg/g of fat, respectively. However, the toxic effects of the dioxins in the milk in this range of concentrations were not explored. Therefore, considering the outbred livestock tissues as better models than inbred laboratory animals, the present study targeted to study the effect of dioxins present in the milk on three-dimensionally (3D) cultured buffalo primary hepatocyte spheroids. The spheroids were treated with a model dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), directly and also through milk fat at different concentrations (i.e, 0.02−20 pg/mL) for 24 h. Among the liver-cell-specific (ALB, HNF4α, and AFP) genes, a similar ALB and upregulated HNF4α expression at all treatments indicated the functional and transcriptionally active hepatocyte spheroids. Supportingly, no significant difference in the antiapoptotic gene expression between the treatments of milk fat and milk fat containing dioxins indicated the survivability of the spheroids during dioxin treatments. Among the selected TCDD responsive (CYP1A1, CYP1A2, AHR, CYP1B1, and TIPARP) genes, a nonsignificant increasing trend of the CYP1A1 expression was observed from 0.2 to 10 pg/mL of TCDD concentration through milk fat. This pattern was similar to the reported insensitive response of human primary hepatocytes toward dioxins than that of rat primary hepatocytes. This may indicate that the buffalo hepatocyte spheroids could be better models than rats for TCDD hepatotoxic studies. Further, TCDD in the milk in the range of 0.02−20 pg/mL concentration may not be very hepatotoxic.

show abstract

“…To study the congener patterns, the levels of congeners (PCDDs, PCDFs, and dl PCBs) were analyzed in pg/g fat (for the sample with fat > 2%) or pg/g (for samples with fat < 2%), as in other studies without the transformation into TEQ (Esposito et al 2010a , 2010b ; Storelli et al 2012 ; Desiato et al 2012 ; Lorenzi et al 2016 ; Rocha et al 2016 ).…”

Section: Methodsmentioning

confidence: 99%

A retrospective study on dioxins and dioxin-like polychlorinated biphenyls in milk and dairy products from the Latium region (Italy) over a 7-year study period (2011–2017)

Battisti

Scaramozzino

Boselli

et al. 2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

This study reports the data of polychlorinated dibenzo-p-dioxins (PCDDs), -furans (PCDFs), and polychlorinated biphenyls dioxin-like (dl PCBs) measured in a total of 260 samples of the dairy supply chain collected over a period of 7 years (2011–2017) in the Latium region (Italy). Levels and average profiles of congeners were reported for each group of the analyzed dairy matrices, and any differences between different sampling strategies were considered (around likely pollutant sources or casual sampling). Of the samples, 95.4% resulted compliant with the regulated levels; only samples belonging to the “sheep bulk milk” matrix were found to be above either the action levels or the maximum levels (tot. 12 samples). Raw milk of the sheep species showed the highest averages (PCDD/F 0.248 and dl PCB 0.966 WHO TEQ pg/g of fat) compared to the milk of other species. The buffalo milk showed a content of dl PCB significantly lower (dl PCB: 0.371 WHO TEQ pg/g of fat) than the sheep milk (p<0.05). Dioxins were found to be superior to furans in almost all dairy products, except in the noncompliant samples where furans were higher. The OCDD was found to be the most abundant congener in almost all dairy products. This study provides a first list of reference values for background contamination of the dairy supply chain in the Latium region. These pre-existing values will be useful in all cases of environmental pollution to identify critical situations.

show abstract

Determination of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in Brazilian cow milk

Cited by 14 publications

References 25 publications

Distribution of Chemical Residues among Fat, Skim, Curd, Whey, and Protein Fractions in Fortified, Pasteurized Milk

Distribution of Chemical Residues among Fat, Skim, Curd, Whey, and Protein Fractions in Fortified, Pasteurized Milk

Effect of Dioxins in Milk on the 3D Cultured Primary Buffalo Hepatocyte Model System

A retrospective study on dioxins and dioxin-like polychlorinated biphenyls in milk and dairy products from the Latium region (Italy) over a 7-year study period (2011–2017)

Contact Info

Product

Resources

About