Determination of platinum by ion-pair reversed-phase high-performance liquid chromatography with 4,4'-bis(dimethylamino)thiobenzophenone

Zhang, Xiaosong; Lin, Chang-Shan; Liu, Luzhou; Qiao, Guijuan

doi:10.1016/0021-9673(94)00641-5

Cited by 10 publications

(1 citation statement)

References 12 publications

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“…Sodium diethyldithiocarbamate (Na-ddtc) is widely used and has been applied to various off-line and on-line HPLC methods [4][5]. o-Phenylenediamine [13], bis (dimethylamine)thiobenzophenone [14] and bis (salicylaldehyde) [15] all yield compounds that are detectable in the UV-VIS region and have been used to quantify the drug itself using HPLC. CDDP and its monohydrated complexes have been determined using post column derivatization with Na-ddtc, using two different, strong anion and cation exchange columns together [8].…”

Section: Introductionmentioning

confidence: 99%

Determination of cisplatin, transplatin and amminetri-chloroplatinate by high performance liquid chromatography in one run using 4-methyl-2-thiouracil as derivatizing agent

1999

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We have developed a simple, rapid, selective and sensitive method for detecting the antitumour agent cisdiamminedichloroplatinum (II) (cisplatin) (CDDP) and its toxic impurities trans-diamminedichloroplatinum (II) (transplatin) (TDDP) amminetri-chloroplatinat (ATCP) anion using HPLC in one run. By using 4methyl-2-thiouracil (MTU) as a derivatizing agent, new compounds have been formed from the Pt compounds and separated on a ~-Bondapak C1s column with isocratic elution and detection at 315 nm. Reactant concentration, methanol content, pH and the reaction time on yield of derivatives were investigated and the optimum conditions for the detection response were defined. The derivatives of each of the three platinum compounds formed in an acetate buffer solution containing 40 % (v/v) methanol and 0.9 % KC1 solution at pH 3.7 and ambient temperature were only stable for one hour.

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Section: Introductionmentioning

confidence: 99%

Determination of cisplatin, transplatin and amminetri-chloroplatinate by high performance liquid chromatography in one run using 4-methyl-2-thiouracil as derivatizing agent

1999

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Capillary gas chromatographic analysis of pyrrolidinedithiocarbamate metal chelates

Laghari

Khuhawar²,

Zardari

2007

J of Separation Science

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Pyrrolidinedithiocarbamate (PDTC) chelates of Zn(II), Cu(II), Ni(II), Co(III), Fe(III), Mn(II), Cr(III), and VO(II) were analysed by capillary GC on a DB-1701 column (30 m x 0.25 mm id) with flame ionisation detection (FID). Linear calibrations were attained within "1-30 microg/mL" for Ni(II), Fe(III), Mn(II), Cr(III), Cu(II), and VO(II), and within "2-50 microg/mL" for Co(III) and Zn(II). The limits of detection were in the "150-500 ng/mL" range, corresponding to 15-50 pg amounts reaching the FID system. The optimised method was applied to the determination of Cu(II) and Ni(II) in coins, and that of Zn(II), Cu(II), Ni(II), Fe(III), Mn(II), Cr(III), and VO(II) in pharmaceutical preparations with relative standard deviations within 1.1-5.2%. The results obtained are in good agreement with sewage water samples and the declared values for the pharmaceutical formulations, or with the results of AAS of metal contents in coins, pharmaceutical preparations, and sewage water samples.

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Capillary gas chromatography of metal chelates of diethyl dithiocarbamates

2002

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SummaryCapillary GC of metal chelates of diethyl dithiocarbamate (DDTC) was examined on a methylsilicone DB-1 column, (25 meter, 0.2 mm. i. d)with a film thickness of 0.25 I~m. Elution was carried out at the initial column temperature of 180~ and programmed at 5~ 1 to 260 ~ Detection was by FID or ECD. Symmetrical peaks with base line separation were obtained with the metal chelates of copper(ll), nickel(ll), cobalt(Ill), manganese(ll) and chromium011). The ECD gave better sensitivity than the FID with a linear calibration range of 5-501~g mL 1 and detection limits 2.0-6.01~g mL 1, corresponding to 111-333 pg of metal ion reaching the detector. The method was applied to the determination of metal ions in water and pharmaceutical preparations with a coefficient of variation (CV)within 4.0%. When compared with a standard flame AAS method the results revealed no significant difference. The present work examines the GC analysis of the metal chelates of diethyldithiocarbamate (DDTC) on a methylsilicone capillary column with FID and ECD detection.

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Determination of platinum by ion-pair reversed-phase high-performance liquid chromatography with 4,4'-bis(dimethylamino)thiobenzophenone

Cited by 10 publications

References 12 publications

Determination of cisplatin, transplatin and amminetri-chloroplatinate by high performance liquid chromatography in one run using 4-methyl-2-thiouracil as derivatizing agent

Determination of cisplatin, transplatin and amminetri-chloroplatinate by high performance liquid chromatography in one run using 4-methyl-2-thiouracil as derivatizing agent

Capillary gas chromatographic analysis of pyrrolidinedithiocarbamate metal chelates

Capillary gas chromatography of metal chelates of diethyl dithiocarbamates

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