Determination of plasminogen/plasmin system components and indicators of lipoproteins oxidative modification under arterial hypertension

Yusova, O. I.; Savchuk, О. V.; Grinenko, T. V.; Kuchmenko, O. B.

doi:10.15407/ubj90.01.058

Cited by 1 publication

(1 citation statement)

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“…The ratio MPO/PON-1 may be used for monitoring of this changing. The index calculated for prediction of development of acute coronary syndrome in patients with CKD of different stages [19]. The ratio MPO/PON-1 soared 4.7 fold in patients with V stage, 2.7 fold in patients with III-IV stage and 2 fold in patients with I stage of CKD in contrast with prac-tically healthy donors (Fig.).…”

Section: Indicatorsmentioning

confidence: 98%

The oxidative status in patients with chronic kidney disease

Vasylchenko¹,

Korol²,

Kuchmenko³

et al. 2020

Ukr.Biochem.J

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an excess of free radicals accompanies the development of renal pathologies and causes numerous concomitant complications and syndromes. the most common of these are cardiometabolic syndromes in patients with chronic kidney disease. therefore, the purpose of the study was to determine the activity of paraoxonase-1 and myeloperoxidase, which are associated with indicators of high-density lipoproteins content and oxidative stress in the blood of patients with the chronic stage of kidney disease. the activity of the enzymes, thiobarbiturate-active products concentration and transferrin, ceruloplasmin, thiol compounds content were determined in the blood of patients with chronic kidney disease. the oxidative status was shown to be changed. thus, myeloperoxidase activity, the content of oxidized proteins and the concentration of thiobarbiturate-positive components were increased, while the activity of the antioxidant enzyme paraoxonase-1, the content of transferrin, ceruloplasmin and thiol compounds were decreased. the ratio of myeloperoxidase / paraoxonase-1 activities was progressively increased up to 9-fold, indicating the presence of cardiovascular complications in patients. the data obtained allowed to extend the range of indicators for monitoring the development of cardiometabolic disorders in the progression of chronic kidney disease. k e y w o r d s: oxidative status, paraoxonase-1, myeloperoxidase, chronic kidney disease.

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Section: Indicatorsmentioning

confidence: 98%