Determination of pioglitazone hydrochloride in bulk and pharmaceutical formulations by HPLC and MEKC methods

Radhakrishna, T; Rao, D Sreenivas; Reddy, G. Om

doi:10.1016/s0731-7085(02)00036-5

Cited by 60 publications

(43 citation statements)

References 16 publications

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“…Examples of studies using HPLC for drug quantification exist are numerous [17][18][19]. For example, Fornaguera et al [19] studied the encapsulation and release kinetics of dexamethasone (an antiinflammatory drug) from polymeric nanoparticles.…”

Section: High-performance Liquid Chromatography (Hplc)mentioning

confidence: 99%

Analytical Methods to Characterize and Purify Polymeric Nanoparticles

Fornaguera

Solans

2018

International Journal of Polymer Science

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Advances in polymeric nanoparticles as novel nanomedicines have opened a new class of diagnostic and therapeutic tools for many diseases. However, although the benchtop research studies in the nanoworld are numerous, their translation to currently marketed products is still limited. This lack of transference can be attributed, among other factors, to problems with nanomedicine characterization. Characterization techniques at the nanoscale could be divided in three categories: characterization of physicochemical properties (e.g., size and surface charge), characterization of nanomaterials interactions with biological components (e.g., proteins from the blood), and analytical characterization and purification methods. Currently available literature of this last group only describes methodologies applied for a specific type of nanomaterial or even methods used for bulk materials, which are not completely applicable to nanomaterials. For this reason, the current review aims to become a scholastic guide for those scientists starting in the nanoworld, giving them a description of analytical characterization techniques aimed to analyze polymers forming nanoparticles and possible forms to purify them before being used in preclinical and clinical applications.

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Section: High-performance Liquid Chromatography (Hplc)mentioning

confidence: 99%

Analytical Methods to Characterize and Purify Polymeric Nanoparticles

Fornaguera

Solans

2018

International Journal of Polymer Science

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“…Computational Methods The general form of the Jouyban-Acree model for calculating the solubility of drugs in binary solvent mixtures at different temperatures is 16) : (1) where C m,T Sat is the molar solute solubility in the solvent mixtures at temperature T, w 1 , and w 2 are the mass fractions of the solvents 1 (i.e. ethanol, PG, NMP or water in this work) and 2 (PEG 400 in this work) in the absence of the solute, C 1,T Sat and C 2,T Sat denote the molar solubility of the solute in the solvents 1 and 2, respectively, and J i are the constants of the model computed by a regression analysis.…”

Section: Apparatus and Proceduresmentioning

confidence: 99%

Solubility of Pioglitazone Hydrochloride in Binary Mixtures of Polyethylene Glycol 400 with Ethanol, Propylene Glycol, N-Methyl-2-pyrrolidone, and Water at 25 .DEG.C

Jouyban

Soltanpour

2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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Pioglitazone (PGZ) or 5-[[4-[2-(5-ethylpyridin-2-yl)-ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione with CAS registry number of 111025-46-8 is a low water-soluble oral hypoglycemic agent which is used as its hydrochloride salt. The solubility of the hydrochloride salt (PGZ-HCl, for its chemical structure, see Fig. 1) is still low and may cause problems in many practical applications.1) Different methods for increasing the aqueous solubility of drugs are; cosolvency, addition of surface active agents, salt formation, complexation, hydrotropism, crystal engineering, preparation of soluble prodrug and more recently addition of ionic liquids. 2-8)Solubilization of poorly soluble drugs is essential for preparation of many commercially available oral solutions, parenteral, soft gelatin and topical pharmaceutical formulations.9) Ethanol is one of the most important and common cosolvents in the pharmaceutical industry and is used in many commercially available oral, parenteral and soft gelatin formulations.9) Propylene glycol (PG) is a stable and low toxic cosolvent which is used in many commercially available oral and parenteral formulations.9,10) Polyethylene glycols (PEGs) are neutral polyethers which are freely soluble in water due to strong hydrogen-bonding with water molecules. Their low toxicity and high aqueous solubility make PEGs as a suitable solvent for various applications in the pharmaceutical, chemical, cosmetic and food industries.11) N-Methyl-2-pyrrolidone (NMP) is very strong solubilizing agent 9) and is an important solvent in extraction, purification and crystallization of drugs. 12,13) Experimental solubility data of many pharmaceutical compounds in both water 14) and waterϩcosolvent mixtures 15) are available in comprehensive published data compilations. It is impossible to experimentally determine the solubility of every drug or potential drug candidate in different water-cosolvent mixtures, and considerable effort has been devoted to the development of mathematical models for estimation of drug solubility in water-cosolvent mixtures. These models were reviewed and their advantages and limitations were discussed. 16) One of these models is the Jouyban-Acree model which was used in predicting the solubility of many pharmaceutical and chemical compounds in binary and ternary solvent mixtures at different temperatures. In addition to the solubility prediction, the model has been used to calculate several physicochemical properties in mixed solvent systems. 16)Available solubility data of PGZ and PGZ-HCl was summarized and the solubility of PGZ-HCl in aqueous mixtures of ethanol, PG and NMP at 25°C was reported in previous publications. 17,18) In this work, the solubility of PGZ-HCl in the binary mixtures of PEG 400 with water, ethanol, PG and NMP at 25°C is reported which extends the solubility database of pharmaceutically interested systems.15) The fitness of the data to the Jouyban-Acree model is also investigated. ExperimentalMaterials PGZ-HCl (with purity of 0.998 in mass fraction) was purchase...

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“…As per the literature, various analytical methods such as membrane sensitive electrode [2], potentiometric [3], ultravioletspectrophotometric [4], high-performance liquid chromatographic (HPLC) methods [5][6][7][8][9][10], ultra-performance liquid chromatograph method [11], and liquid chromatography-mass spectrometry (LCMS) methods [12][13][14][15][16][17] have been reported for the determination of PG and its metabolites. The particular described methods have to sacrifice time, resolution as well as sensitivity.…”

Section: Introductionmentioning

confidence: 99%

A Rapid and Sensitive Liquid Chromatography- Mass Spectrometry/Mass Spectrometry Method for Estimation of Pioglitazone, Keto Pioglitazone and Hydroxy Pioglitazone in Human Plasma

Ponnuri

Pragallapati

Ravindra³

et al. 2017

Asian J Pharm Clin Res

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Objective: The main objective of the work was to develop a straightforward, fast and selective liquid chromatography/tandem mass spectrometry (LC-MS/MS) assay for determination of pioglitazone (PG), keto pioglitazone (KPG), and hydroxy pioglitazone (HPG) in human plasma and to validate as per recent guidelines. Methods:Analyte and the internal standard (IS) were extracted from plasma through liquid-liquid extraction and chromatographed on a Xterra RP18, 100×4.6, 5 µ column using methanol: acetonitrile mixture and 10 mM Ammonium formate buffer (70:30, v/v) as the mobile phase at a flow rate of 0.7 mL/min. The API-3200 Q Trap LC-MS/MS instrument in multiple reaction monitoring mode was used for detection. Diphenhydramine was utilized as IS. Results:The linearity was established in the concentration range of 20.15-1007.58 ng/mL for PG, 20.35-1017.58 ng/mL for KPG, and 19.68-491.22 ng/mL for HPG in human plasma. All the validation parameters were well within the acceptance limits. Conclusion:A new simple LC-MS/MS method was developed for the determination of PG, KPG, and HPG in human plasma. This method can be easily applied for the estimation of pharmacokinetic parameters of PG, KPG, and HPG.

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Determination of pioglitazone hydrochloride in bulk and pharmaceutical formulations by HPLC and MEKC methods

Cited by 60 publications

References 16 publications

Analytical Methods to Characterize and Purify Polymeric Nanoparticles

Analytical Methods to Characterize and Purify Polymeric Nanoparticles

Solubility of Pioglitazone Hydrochloride in Binary Mixtures of Polyethylene Glycol 400 with Ethanol, Propylene Glycol, N-Methyl-2-pyrrolidone, and Water at 25 .DEG.C

A Rapid and Sensitive Liquid Chromatography- Mass Spectrometry/Mass Spectrometry Method for Estimation of Pioglitazone, Keto Pioglitazone and Hydroxy Pioglitazone in Human Plasma

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