Determination of Pindolol in Human Serum by HPLC

Chmielowiec, D.; Schuster, David P.; Gengo, Fran M.

doi:10.1093/chromsci/29.1.37

Cited by 13 publications

(1 citation statement)

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“…The 50-mL aliquots were injected and eluted with a mobile phase containing 3.9 g ammonium acetate in 810 mL water, 2 mL triethylamine, 10 mL glacial acetic acid, 3 mL phosphoric acid, and 146 mL acetonitrile. 55 The flow rate was set at 1 mL/min, and the eluent was monitored at 275 nm. A calibration curve of MT in the plasma was constructed using blank plasma spiked with standard MT solutions to obtain a concentration range of 0.3–30 mg/mL.…”

Section: Methodsmentioning

confidence: 99%

Sublingual fast dissolving niosomal films for enhanced bioavailability and prolonged effect of metoprolol tartrate

Allam¹,

Fetih²

2016

DDDT

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The aim of the present work was to prepare and evaluate sublingual fast dissolving films containing metoprolol tartrate-loaded niosomes. Niosomes were utilized to allow for prolonged release of the drug, whereas the films were used to increase the drug’s bioavailability via the sublingual route. Niosomes were prepared using span 60 and cholesterol at different drug to surfactant ratios. The niosomes were characterized for size, zeta-potential, and entrapment efficiency. The selected niosomal formulation was incorporated into polymeric films using hydroxypropyl methyl cellulose E15 and methyl cellulose as film-forming polymers and Avicel as superdisintegrant. The physical characteristics (appearance, texture, pH, uniformity of weight and thickness, disintegration time, and palatability) of the prepared films were studied, in addition to evaluating the in vitro drug release, stability, and in vivo pharmacokinetics in rabbits. The release of the drug from the medicated film was fast (99.9% of the drug was released within 30 minutes), while the drug loaded into the niosomes, either incorporated into the film or not, showed only 22.85% drug release within the same time. The selected sublingual film showed significantly higher rate of drug absorption and higher drug plasma levels compared with that of commercial oral tablet. The plasma levels remained detectable for 24 hours following sublingual administration, compared with only 12 hours after administration of the oral tablet. In addition, the absolute bioavailability of the drug (ie, relative to intravenous administration) following sublingual administration was found to be significantly higher (91.06%±13.28%), as compared with that after oral tablet administration (39.37%±11.4%). These results indicate that the fast dissolving niosomal film could be a promising delivery system to enhance the bioavailability and prolong the therapeutic effect of metoprolol tartrate.

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Section: Methodsmentioning

confidence: 99%

Sublingual fast dissolving niosomal films for enhanced bioavailability and prolonged effect of metoprolol tartrate

Allam¹,

Fetih²

2016

DDDT

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Conductometric titration of pindolol and propranolol using ammonium reineckate and potassium tetracyanonickelate

Issa

Amin

1995

Mikrochim Acta

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Pindolol binding to 5-HT 1A receptors in the human brain confirmed with positron emission tomography

Andrée

Thorberg²,

Halldin

et al. 1999

Psychopharmacology

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The augmentation effect of (-)pindolol as used in combination with SSRI to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-HT autoreceptors. In this study, the radioligand [carbonyl-11C]WAY-100635 and positron emission tomography were used to establish whether pindolol at a clinical dose level (10 mg s.o.d.) occupies 5-HT1A receptors in the human brain in vivo. Three healthy males were recruited and each subject was used as his own control. The 5-HT1A receptor occupancy was calculated for the frontal and temporal cortex and the raphe nuclei, using and a ratio analysis with the cerebellar cortex as the reference region. Maximal pindolol plasma concentration was reached within 3 h after drug administration. Two hours after pindolol administration, the regional 5-HT1A receptor occupancy was within the range 7-21% in the three subjects. The study confirms that the 5-HT1A-receptor may be a clinically significant target for pindolol.

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Determination of Pindolol in Human Serum by HPLC

Cited by 13 publications

References 0 publications

Sublingual fast dissolving niosomal films for enhanced bioavailability and prolonged effect of metoprolol tartrate

Sublingual fast dissolving niosomal films for enhanced bioavailability and prolonged effect of metoprolol tartrate

Conductometric titration of pindolol and propranolol using ammonium reineckate and potassium tetracyanonickelate

Pindolol binding to 5-HT 1A receptors in the human brain confirmed with positron emission tomography

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