Determination of phenytoin in plasma by molecularly imprinted solid-phase extraction

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

“…The purpose is to first quantitatively trap the analyte from the aqueous sample using both selective imprint binding and non-specific adsorption, and then change to an organic solvent in which the imprints bind the analyte in a highly selective manner, and in which nonspecific MIP-analyte adsorption is weak or absent. Bioanalytical applications include: extraction of bupivacaine from human plasma on a pentycaine-MIP; 916,1138 darifenacin on a darifenacin-MIP; 421,899 and caffeine on a caffeine-MIP in both instances after protein precipitation with acetonitrile; 991 tamoxifen from human plasma and urine on a tamoxifen-MIP; 1139,1140 scopolamine from human and calf serum on a hyoscyamine-MIP; 902 phenytoin from plasma on a phenytoin-MIP; 1141 quercetin from rat plasma on a quercetin-MIP prepared using acrylamide as functional monomer; 1142 phenobarbital from human urine and tablets on amobarbital imprinted microspheres; 1143 7-hydroxycoumarin on a hydroxycoumarin-MIP from human urine; 1144 chlorphenamine from aqueous standards on a chlorphenamine-MIP; 1145 atenolol on an atenolol-MIP; 1112 drug F on a MIP prepared against a structural analogue from aqueous standards; 1146 and -lactam antibiotics from diluted drug formulations on a cefaclor-MIP. 245 Conditions for the extraction of propranolol and structural analogues of propranolol from dog plasma, rat bile and human urine using propranolol-MIPs were studied in detail.…”

Characteristic and Synthetic Approach of Molecularly Imprinted Polymer

“…MIP possess several advantages over their biological counterparts including low cost, ease of preparation, storage stability, repeated operations without loss of activity, high mechanical strength, durability to heat and pressure, and applicability in harsh chemical media. As a technique for the creation of artificial receptor-like binding sites with a 'memory' for the shape and functional group positions of the template molecule, molecular imprinting has become increasingly attractive in many fields of chemistry and biology, particularly as an affinity material for sensors [7][8][9][10][11], binding assays [12], artificial antibodies [13][14], adsorbents for solid phase extraction [15][16][17][18][19], and chromatographic stationary phases [20][21][22][23].…”

Selective enrichment of anti‐inflammatory drugs from river water samples by solid‐phase extraction with a molecularly imprinted polymer

“…In the present work, and before each clean-up step, the cartridge was dried for 15 min by applying a vacuum [16][17][18][19][20][21]. DCM was used to perform the clean-up because when more polar solvents were used, the recovery for ibuprofen and the other NSAIDs decreased.…”