Determination of phenolic derivatives of antipyrine in plasma with solid-phase extraction and high-performance liquid chromatography–atmospheric-pressure chemical ionization mass spectrometry

Coolen, Saj Stefan; Ligor, Tomasz; Lieshout, van Hpm Mark; Huf, FA Fred

doi:10.1016/s0378-4347(99)00275-3

Cited by 30 publications

(17 citation statements)

References 15 publications

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“…3. The spectra demonstrates bands of the LiClO 4 -in doped PPy. In this spectra, one can notice an intensive broad band (1) pyrrole ring.…”

Section: Characterization Of the Fibersmentioning

confidence: 97%

“…The band (4) at m = 1424 cm -1 corresponds to C -N stretching mode in pyrrole ring of PPy [24]. Broad band (5) between m = 1200 -1000 cm -1 is due to Cl -O stretching vibrations of LiClO 4 -ion. Strong signal (6) at m = 627 cm -1 contains two important peaks, one due to NH out of plane vibrations [25] appearing usually at m = 620 cm -1 and the other, strong peak appearing at m = 624 cm -1 which is characteristic for the LiClO 4 -ion [26].…”

Section: Characterization Of the Fibersmentioning

confidence: 98%

“…In this case we have been using 0.12 mol/dm 3 solution of LiClO 4 -in methanol. The water solution of electrolyte was not used because during the first trial it appeared that in water electrolyte the polymer tended to fall off from the metal support.…”

Section: Characterization Of the Fibersmentioning

confidence: 99%

“…In calculation of c S * value it was assumed that the polymer contains only C atoms (73.6 l 0.5%), H atoms (5.7 l 0.3%), and N atoms (20.7 l 0.4). The rest of the sample mass is the dopant which is ClO 4 -ions. The sample, then contains 61.8 l 0.3% of pure polymer.…”

Section: Characterization Of the Fibersmentioning

confidence: 99%

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Preparation and characterization of microporous fibers for sample preparation and LC‐MS determination of drugs

Buszewski¹,

Nowaczyk

Ligor

et al. 2009

J of Separation Science

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The aim of this study was the preparation of polypyrrole (PPy) fibers for solid phase microextraction (SPME). PPy coatings were obtained during the electrochemical polymerization process. The utility of various metal wires (Fe, Cu, Ag, Cu/Ag, kanthal and medical stainless steel) as a support for polymers was compared. Various experimental conditions of the synthesis process such as scan rate, voltage limits and number of scans and deposition time were applied. The average polymer thickness was in the range of 7-125 microm and its weight was in the scope of 0.65-5.6 mg. Different techniques, mainly elemental analysis, Fourier transform infrared spectroscopy, microscopy, and chromatography were performed for the characterization of obtained fibers with microporous structure. The extraction efficiency of cardiovascular drugs (metoprolol, propranolol, oxprenolol, propafenone and mexiletine) by means of fibers was tested. The concentration of mentioned compounds in standard solution was in the span of 10-150 ng/mL. LC-MS was employed for determination of drugs in desorption solution. LODs varied from 0.013 to 1.51 ng/mL for metoprolol and mexiletine respectively. The repeatability of extraction was obtained with the RSD values lower than 10%.

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“…3. The spectra demonstrates bands of the LiClO 4 -in doped PPy. In this spectra, one can notice an intensive broad band (1) pyrrole ring.…”

Section: Characterization Of the Fibersmentioning

confidence: 97%

Section: Characterization Of the Fibersmentioning

confidence: 98%

Section: Characterization Of the Fibersmentioning

confidence: 99%

Section: Characterization Of the Fibersmentioning

confidence: 99%

See 2 more Smart Citations

Preparation and characterization of microporous fibers for sample preparation and LC‐MS determination of drugs

Buszewski¹,

Nowaczyk

Ligor

et al. 2009

J of Separation Science

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show abstract

“…[11] Moreover, APDs have been further investigated as a new type of nonlinear optoelectronic materials according to their promising optical characteristics. [12,13] Due to the profound potential applications of APDs, several protocols to synthesize new heterocycles derivates were reported. [2,14 -16] Several APDs have been characterized with elemental analysis, FT-IR, FT-Raman, UV-vis spectroscopy and X-ray single crystal diffraction techniques combining with density functional theory calculations.…”

Section: Introductionmentioning

confidence: 99%

VUV photon‐induced ionization/dissociation of antipyrine and propyphenazone: mass spectrometric and theoretical insights

et al. 2010

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Two analgesic and anti-inflammatory drugs, antipyrine and propyphenazone, were investigated with infrared laser desorption/tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometry (IR LD/VUV PIMS) and theoretical calculations. Mass spectra of the two drugs were measured at various photon energies. Fragment ions were gradually produced as photon energy increases. The structural assignment of the dominant fragment ions was supported by the results from a commercial electron impact time-of-flight mass spectrometer (EI-TOF MS). Primary fragmentation pathways were established from experimental observations combining with theoretical calculations. Methyl radical elimination is a common fragmentation pathway for two analytes. However, for propyphenazone cation, isopropyl group elimination to form antipyrine cation is another competitive pathway.

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Determination of phenolic derivatives of antipyrine in plasma with HPLC-Tandem MS using ESI and turbo ion spray as interfaces

Coolen¹,

Lieshout²,

Huf³

1999

J. Micro. Sep.

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Determination of phenolic derivatives of antipyrine in plasma with solid-phase extraction and high-performance liquid chromatography–atmospheric-pressure chemical ionization mass spectrometry

Cited by 30 publications

References 15 publications

Preparation and characterization of microporous fibers for sample preparation and LC‐MS determination of drugs

Preparation and characterization of microporous fibers for sample preparation and LC‐MS determination of drugs

VUV photon‐induced ionization/dissociation of antipyrine and propyphenazone: mass spectrometric and theoretical insights

Determination of phenolic derivatives of antipyrine in plasma with HPLC-Tandem MS using ESI and turbo ion spray as interfaces

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