Determination of paroxetine in plasma by high-performance liquid chromatography for bioequivalence studies

López-Calull, C; Domínguez, Noelia Cabaleiro

doi:10.1016/s0378-4347(98)00560-x

Cited by 29 publications

(14 citation statements)

References 9 publications

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“…195 Paroxetine is derivatized with pentafluorobenzyl carbamate or heptafluorobutyric anhydride before injection onto a GC-MS in negative chemical ionization mode or on a GC-ECD configuration. 298−300 In LC, the following detectors are used: UV, 147,228,229,301,302 DAD, 146 fluorescence, 50,57,147,232,303,304 coulometric detection, 305 and mass detectors in electrospray 152,306,307 as well as in APCI mode. 153 When using the UV detector, a typical spectrum arises in acidic conditions at absorption of 233, 264, 270 and 293 nm.…”

Section: Methodsmentioning

confidence: 99%

Relevant Issues in the Monitoring and the Toxicology of Antidepressants

Wille

Cooreman

Neels

et al. 2008

Critical Reviews in Clinical Laboratory Sciences

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2 This review provides specific information concerning the interpretation and usefulness of antidepressant drug monitoring. Fifteen antidepressants (ADs) were selected based on their importance in the 7 major markets (Japan, USA, France, United Kingdom, Italy, Spain, Germany) according to the Cognos Plus Study #11. Literature data were reviewed concerning monitoring of the tricyclic ADs amitriptyline, clomipramine, imipramine, and new generation antidepressants such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine, mianserin, mirtazapine, bupropion, and milnacipran. In addition, St.-John's Wort was added as this natural antidepressant is very popular in Europe. The objectives of therapeutic drug monitoring (TDM) for old and new generation ADs differs, as older ADs have narrow therapeutic windows with higher risks of severe drug interactions, while the new ADs have a wide therapeutic range, but an unclear plasma concentration-effect relationship. Therefore, the purpose of TDM for new-generation ADs leads more to the monitoring of patient compliance and special patient groups such as the elderly, patients with liver and kidney impairment, patients with poor metabolism by CYP 450 and comedication with inhibitors and inducers of those enzymes.Keywords Depression, monoamine oxidase inhibitors, noradrenergic and specific serotonergic antidepressants, serotonin-antagonist and reuptake inhibitors, selective noradrenaline reuptake inhibitors, selective serotonin reuptake enhancer, selective serotonin reuptake inhibitors, serotonin and noradrenaline reuptake inhibitors, tricyclic antidepressants, therapeutic drug monitoring, analytical methods, St. John's Wort. 25Critical Reviews in Clinical Laboratory Sciences Downloaded from informahealthcare.com by Dokuz Eylul Univ. on 11/05/14For personal use only. 26 S. M. R. Wille et al.

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Section: Methodsmentioning

confidence: 99%

Relevant Issues in the Monitoring and the Toxicology of Antidepressants

Wille

Cooreman

Neels

et al. 2008

Critical Reviews in Clinical Laboratory Sciences

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“…Some analytical methods, such as HPLC, [2][3][4][5][6][7][8][9][10][11][12] HPLC-GC, 13 GC, 14 GC-MS 15 and capillary liquid chromatography 16 have been reported for PRX in biological fluids and pharmaceutical dosage forms.…”

Section: Introductionmentioning

confidence: 99%

Simple Method of Paroxetine Determination Usinga Single Channe lFIA with No In-line Reaction Process

Altıokka

Kircali

2003

ANAL. SCI.

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“…gas chromatography (GC) with electro-capture detection (Lai et al, 2000), nitrogen-phosphorus detection (Lacassie et al, 2000) or negative ion chemical ionization mass spectrometry (Leis et al, 2001(Leis et al, , 2002 and liquid chromatography (LC) with ultraviolet (UV) detection (Foglia et al, 1997;Bagli et al, 1997;Molander et al, 2002;Kristoffersen et al, 1999), and fluorescence detection (Lacassie et al, 2000;Kristoffersen et al, 2000;Lopez-Calull and Dominguez, 1999;Shin et al, 1998) have appeared in literature to analyze paroxetine in biological fluids. Methods published prior to 1996 have been summarized in a review article (Eap and Baumann, 1996).…”

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confidence: 99%

Development and validation of a hydrophilic interaction liquid chromatography–tandem mass spectrometric method for the analysis of paroxetine in human plasma

Weng

Eerkes

2003

Biomedical Chromatography

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A sensitive, simple, fast and rugged hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) method for the determination of paroxetine was developed and validated over curve range 0.050-50 ng/mL using only 0.4 mL plasma. This is the first published LC-MS/MS method and the low limit of quantitation of this method is 10-fold lower than previously published methods. A simple liquid-liquid extraction method using methyl-tert butyl ether (MTBE) as the extraction solvent was used to extract paroxetine and the internal standard (IS) fentanyl-d(5) from plasma. The extract was evaporated to dryness, reconstituted and injected onto a silica column using a low aqueous-high organic mobile phase. The chromatographic run time was 2.0 min per injection, with retention times of 1.1 and 1.2 min for paroxetine and IS, respectively. The detection was by monitoring paroxetine at m/z 330 --> 192 and IS at m/z 342 --> 188, respectively. The inter-day precision and accuracy of the quality control (QC) samples were <5.0% relative standard deviation (RSD) and <2.9% relative error (RE). This method can be used for supporting therapeutical drug monitoring and pharmacokinetic or drug-drug interaction studies.

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Determination of paroxetine in plasma by high-performance liquid chromatography for bioequivalence studies

Cited by 29 publications

References 9 publications

Relevant Issues in the Monitoring and the Toxicology of Antidepressants

Relevant Issues in the Monitoring and the Toxicology of Antidepressants

Simple Method of Paroxetine Determination Usinga Single Channe lFIA with No In-line Reaction Process

Development and validation of a hydrophilic interaction liquid chromatography–tandem mass spectrometric method for the analysis of paroxetine in human plasma

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