Determination of Paracetamol and Kinetic Parameters Using Nickel Hexacyanoferrate Modified Carbon Paste Electrode.

Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode

“…Further evidence for non-diffusion behaviour of paracetamol was obtained, when the working electrode was switched to a medium containing only phosphate buffer solution after being in voltammetric measurements of paracetamol solution, voltammetric signal was observed [7]. This indicates paracetamol shows adsorption controlled process.…”

“…The ratio of redox peak current (I pa/ I pc ) was 1.85, which shows the characteristics of irreversible electrode process. However for reversible electrode reaction the ratio of I pa to that of I pc is one [7]. Activated glassy carbon electrode shows a fast electron transfer rate due to good conductivity and a large capacitive current of the electrode.…”

“…To optimize the response of activated glassy carbon electrode for paracetamol oxidation, the effect of pH on the electrochemical oxidation was investigated by cyclic voltammetry technique at different pH using phosphate buffer solution with a pH range of 4 -10 at a scan rate of 100 mV/s to determine its effect on the catalytic oxidation of 0.1mmol L -1 paracetamol at activated glassy carbon electrode [20]. As shown Figure 3, the pH of the solution influenced the potential and the currents of both cathodic and anodic peaks of paracetamol.…”

“…Generally, the electrochemical oxidation of paracetamol at activated glassy carbon electrode is pH dependent. At a pH near to 7.0 N-acetyl-p-Quinoneimine exists in its stable and unprotonated form [7]. If the pH was higher than 7, the drugs inclined to decompose, resulting in the decrease of the response.…”

“…However, the overdose of paracetamol can lead to the accumulation of toxics metabolites, which may cause liver disorder, kidney damage, skin rashes and inflammatory of the pancreas [5]. Paracetamol described as 4hydroxyacetanlide or N-acetyl-p-aminophenol is known as acetaminophen [7] and its chemical formula, C 8 H 9 NO 2 and its structure is as shown below, The development of simple, sensitive and accurate electroanalytical methods for the determination of paracetamol is very important. The various techniques have been employed for the determination of paracetamol in the body fluids and pharmaceuticals preparations including spectroscopy, chromatography, titrimetry and chemiluminscence [8,11,12,14].…”