Determination of parabens and benzophenone-type UV filters in human placenta. First description of the existence of benzyl paraben and benzophenone-4

Valle-Sistac, Jennifer; Molins-Delgado, Daniel; Díaz, Marta; Ibáñez, Lourdes; Barceló, Damià; Díaz˗Cruz, M. Silvia

doi:10.1016/j.envint.2015.12.034

Cited by 125 publications

(48 citation statements)

References 52 publications

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“…Parabens have been detected in human urine, serum, adipose tissue, milk, amniotic fluid and placental tissue [107][108][109][110][111][112][113], and in human breast cancer tissues [114,115]. In humans, dermal exposure to paraben-containing products is important for their absorption because some parabens penetrate the human skin [116]; the systemic absorption of parabens after environmental exposure has also been confirmed, although it seems to be a less important paraben source [38].…”

Section: Parabensmentioning

confidence: 97%

Cosmetic Ingredients as Emerging Pollutants of Environmental and Health Concern. A Mini-Review

2017

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Cosmetic and personal care products are used in huge quantities throughout the world; as a result of their regular use, they are continuously released into the environment in very large amounts. Many of these products are biologically active and are characterized by persistence and bioaccumulation potential, posing a threat to ecosystem and human health. On the basis of the most recent scientific literature available on this subject, this paper provides an overview of some cosmetic ingredients that are considered environmental emerging pollutants of particular concern such as UV filters, some preservatives (parabens, triclosan), and microplastics.

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Section: Parabensmentioning

confidence: 97%

Cosmetic Ingredients as Emerging Pollutants of Environmental and Health Concern. A Mini-Review

2017

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“…Analyses of parabens in maternal blood and paired cord blood from 46 mother-baby pairs showed that methylparaben crossed the placenta [244]. Placentas from twelve full-term singleton pregnancies were collected and tissue samples from the maternal side was dissected out and frozen [245]. The samples were analyzed for five parabens and two UV-filters.…”

Section: Foetal Exposure: Programming and Epigeneticsmentioning

confidence: 99%

New EU criteria for endocrine disrupters

2018

TemaNord

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“…BP‐3 has been measured in ≥95% of human urine samples from the USA (Calafat, Wong, Ye, Reidy, & Needham, ; Mortensen et al, ), but has also been reported in human urine samples from Belgium (Dewalque, Pirard, Dubois, & Charlier, ) and from Puerto Rico (Meeker et al, ). BP‐1 is found widely in human urine samples due to it being a metabolite of BP‐3 (Kunisue et al, ), and BP‐1 has been detected in all assayed samples of human placenta (Valle‐Sistac et al, ). BP‐3, OMC, 4‐MBC, HS (Schlumpf et al, ), BP‐3 and BP‐1 (Rodriguez‐Gomez, Zafra‐Gomez, Dorival‐Garcia, Ballesteros, & Navalon, ) have been measured in human milk.…”

Section: Introductionmentioning

confidence: 99%

Measurement of concentrations of four chemical ultraviolet filters in human breast tissue at serial locations across the breast

Barr

Alamer

Darbre

2018

J of Applied Toxicology

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The human population is widely exposed to benzophenone-3 (BP-3), octylmethoxycinnamate (OMC), 4-methylbenzilidenecamphor (4-MBC) and homosalate from their use in consumer goods to absorb ultraviolet (UV) light. Their oestrogenic activity and presence in human milk suggest a potential to influence breast cancer development. In this study, high-performance liquid chromatography-tandem mass spectrometry was used to measure concentrations of these UV filters in human breast tissue from three serial locations across the breast from 40 women undergoing mastectomy for primary breast cancer. One or more of these UV filters were quantifiable in 101 of 120 (84%) of the tissue samples and at least one breast region for 38 of 40 women. BP-3 was measured in 83 of 120 (69%) tissue samples and at least one breast region for 33 of 40 women (range 0-26.0 ng g tissue). OMC was measured in 89 of 120 (74%) tissue samples and at least one breast region for 33 of 40 women (range 0-58.7 ng g tissue). 4-MBC was measured in 15 of 120 (13%) tissue samples and at least one breast region for seven of 40 women (range 0-25.6 ng g tissue). Homosalate was not detected in any sample. Spearman's analyses showed significant positive correlations between concentrations of BP-3 and OMC in each of the three breast regions. For ethical reasons cancerous tissue was not available, but as the location of the cancer was known, Mann-Whitney U-tests investigated any link between chemical concentration and whether a tumour was present in that region or not. For the lateral region, more BP-3 was measured when a tumour was present (P = .007) and for OMC the P value was .061. For seven (of 40) women with measurable 4-MBC, six of seven had measurable 4-MBC at the site of the tumour.

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Determination of parabens and benzophenone-type UV filters in human placenta. First description of the existence of benzyl paraben and benzophenone-4

Cited by 125 publications

References 52 publications

Cosmetic Ingredients as Emerging Pollutants of Environmental and Health Concern. A Mini-Review

Cosmetic Ingredients as Emerging Pollutants of Environmental and Health Concern. A Mini-Review

New EU criteria for endocrine disrupters

Measurement of concentrations of four chemical ultraviolet filters in human breast tissue at serial locations across the breast

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