Determination of Oxygen Heterocyclic Components in Citrus Products by HPLC with UV Detection

Dugo, Paola; Piperno, Anna; Romeo, Roberto; Cambria, M.G.; Russo, Marina; Carnovale, Caterina; Mondello, Luigi

doi:10.1021/jf901209r

Cited by 61 publications

(82 citation statements)

References 37 publications

(59 reference statements)

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“…Fragmentation in the negative mode MS-MS spectrum of 12 and 13, focused on the pseudomolecular ions at 723 and 753, respectively, showed the appearance, of peaks corresponding to the loss of C 4 H 6 O 3 and C 6 (Dugo et al, 2009), depicted in Fig. 4, which was found for the first time in sour orange juice.…”

Section: Identification Of Flavonoids and Furocoumarismentioning

confidence: 94%

Distribution of C- and O-glycosyl flavonoids, (3-hydroxy-3-methylglutaryl)glycosyl flavanones and furocoumarins in Citrus aurantium L. juice

et al. 2011

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Section: Identification Of Flavonoids and Furocoumarismentioning

confidence: 94%

Distribution of C- and O-glycosyl flavonoids, (3-hydroxy-3-methylglutaryl)glycosyl flavanones and furocoumarins in Citrus aurantium L. juice

et al. 2011

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“…Studies on the nonvolatile constituents of Citrus essential oil began in the 1960s (for review, see Dugo et al, 2009), but reliable quantifications for grapefruit were not reported until much later (McHale and Sheridan, 1989;Frérot and Decorzant, 2004;Dugo et al, 2010). All of these studies used cold-pressed grapefruit oil for phytochemical and chemometric analyses.…”

Section: Chemical Analysis Of Grapefruit Peel Essential Oil Collectedmentioning

confidence: 99%

Assessing the Biosynthetic Capabilities of Secretory Glands inCitrusPeel

2012

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Epithelial cells (ECs) lining the secretory cavities of Citrus peel have been hypothesized to be responsible for the synthesis of essential oil, but direct evidence for such a role is currently sparse. We used laser-capture microdissection and pressure catapulting to isolate ECs and parenchyma cells (as controls not synthesizing oil) from the peel of young grapefruit (Citrus × paradisi ‘Duncan’), isolated RNA, and evaluated transcript patterns based on oligonucleotide microarrays. A Gene Ontology analysis of these data sets indicated an enrichment of genes involved in the biosynthesis of volatile terpenoids and nonvolatile phenylpropanoids in ECs (when compared with parenchyma cells), thus indicating a significant metabolic specialization in this cell type. The gene expression patterns in ECs were consistent with the accumulation of the major essential oil constituents (monoterpenes, prenylated coumarins, and polymethoxylated flavonoids). Morphometric analyses demonstrated that secretory cavities are formed early during fruit development, whereas the expansion of cavities, and thus oil accumulation, correlates with later stages of fruit expansion. Our studies have laid the methodological and experimental groundwork for a vastly improved knowledge of the as yet poorly understood processes controlling essential oil biosynthesis in Citrus peel.

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“…1 Citrus products are rich sources of psoralens, a group of naturally occurring furocoumarins (furanocoumarins). [2][3][4][5] Photochemotherapy using oral psoralen (methoxsalen) and ultraviolet (UV) A radiation (PUVA) is a highly effective therapy for severe psoriasis. 6 PUVA takes advantage of the high UV absorbance of psoralen.…”

Section: Introductionmentioning

confidence: 99%

Citrus Consumption and Risk of Cutaneous Malignant Melanoma

Han

Feskanich

et al. 2015

JCO

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Purpose Citrus products are widely consumed foods that are rich in psoralens and furocoumarins, a group of naturally occurring chemicals with potential photocarcinogenic properties. We prospectively evaluated the risk of cutaneous malignant melanoma associated with citrus consumption. Methods A total of 63,810 women in the Nurses' Health Study (1984 to 2010) and 41,622 men in the Health Professionals Follow-Up Study (1986 to 2010) were included. Dietary information was repeatedly assessed every 2 to 4 years during follow-up. Incident melanoma cases were identified through self-report and confirmed by pathologic records. Results Over 24 to 26 years of follow-up, we documented 1,840 incident melanomas. After adjustment for other risk factors, the pooled multivariable hazard ratios for melanoma were 1.00 for overall citrus consumption < twice per week (reference), 1.10 (95% CI, 0.94 to 1.30) for two to four times per week, 1.26 (95% CI, 1.08 to 1.47) for five to six times per week, 1.27 (95% CI, 1.09 to 1.49) for once to 1.5 times per day, and 1.36 (95% CI, 1.14 to 1.63) for ≥ 1.6 times per day (Ptrend < .001). Among individual citrus products, grapefruit showed the most apparent association with risk of melanoma, which was independent of other lifestyle and dietary factors. The pooled multivariable hazard ratio for melanoma comparing the extreme consumption categories of grapefruit (≥ three times per week v never) was 1.41 (95% CI, 1.10 to 1.82; Ptrend < .001). Conclusion Citrus consumption was associated with an increased risk of malignant melanoma in two cohorts of women and men. Nevertheless, further investigation is needed to confirm our findings and explore related health implications.

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Determination of Oxygen Heterocyclic Components in Citrus Products by HPLC with UV Detection

Cited by 61 publications

References 37 publications

Distribution of C- and O-glycosyl flavonoids, (3-hydroxy-3-methylglutaryl)glycosyl flavanones and furocoumarins in Citrus aurantium L. juice

Distribution of C- and O-glycosyl flavonoids, (3-hydroxy-3-methylglutaryl)glycosyl flavanones and furocoumarins in Citrus aurantium L. juice

Assessing the Biosynthetic Capabilities of Secretory Glands inCitrusPeel

Citrus Consumption and Risk of Cutaneous Malignant Melanoma

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