Determination of oxidative stress in vitiligo by measuring superoxide dismutase and catalase levels in vitiliginous and non-vitiliginous skin

Sravani, P V; Babu, Neerupudi Kishore; Gopal, K.; Rao, G Raghu Rama; Rao, A.Rama Mohana; Moorthy, Bhagavatula; Rao, T. Raghava

doi:10.4103/0378-6323.48427

Cited by 87 publications

(30 citation statements)

References 17 publications

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“…Furthermore, ROSs show a paradoxical effect on melanocytes, both inducing depigmentation and increasing the skin pigmentation. The skin of patients with vitiligo vulgaris, characterized by circumscribed depigmented macules, contains high levels of SOD and low levels of CAT [6]. Impaired nuclear factor erythroid 2-like 2 (NRF2) signaling and decreased antioxidative enzyme levels, including heme oxygenase-1 (HMOX1), have been reported in patients with vitiligo.…”

Section: Physiological Ros Rolesmentioning

confidence: 99%

Reactive Oxygen Species in Skin Repair, Regeneration, Aging, and Inflammation

Xu¹,

Zheng²,

Liu³

et al. 2018

Reactive Oxygen Species (ROS) in Living Cells

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As the most important and largest surface barrier, the skin provides a necessary protection to the organism from the external factors, including chemical, biological, and physical irritation, injury, and others. External environmental irritants or their metabolites are inherent oxidants and/or directly or indirectly drive the production of various reactive oxidants, reactive oxygen species (ROSs), owing to the redox imbalances. ROSs, the most common free oxygen radicals, participate in a series of physiological and pathological skin processes. Here, we discussed the role of oxidative events in injury, repair, photoaging, and cutaneous disease development. Intrinsic and extrinsic factors lead to the skin barrier damage, which leads to the disequilibrium in oxidant and antioxidant balance and induces excessive ROS production. The underlying mechanisms include DNA damage, MAPK/AP-1, NF-κB, and JAK/STAT-signaling pathways, apoptosis and autophagy, and autoimmune reaction of melanocytes and keratinocytes. The skin employs a number of antioxidant agents to protect the oxidative balance, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), ascorbic acid, and tocopherols. The results presented here indicate that antioxidant treatments may be effective when applied in the therapy of cutaneous diseases where oxidative stress plays a prominent pathogenic role.

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Section: Physiological Ros Rolesmentioning

confidence: 99%

Reactive Oxygen Species in Skin Repair, Regeneration, Aging, and Inflammation

Xu¹,

Zheng²,

Liu³

et al. 2018

Reactive Oxygen Species (ROS) in Living Cells

View full text Add to dashboard Cite

show abstract

“…Increased activity of MAO is reported in vitiligo epidermis that results in accumulation of H 2 O 2 68 . Low levels of antioxidants, such as catalase, glutathione peroxidase, and superoxide dismutase are reported in the epidermis and serum of vitiligo patients 69,70 . The inverse relationship between vitiligo and smoking might be explained by inhibitory effects on MAO due to tobacco smoking 62 .…”

Section: Discussionmentioning

confidence: 99%

Association between vitiligo and smoking: A nationwide population-based study in Korea

Lee

et al. 2020

Sci Rep

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no study has examined the associations between vitiligo and smoking. the purpose of this study was to investigate the incidence of vitiligo according to smoking status. We used clinical data from individuals aged over 20 years who received a health examination in the National Insurance Program between 2009 and 2012 (n = 23,503,807). We excluded individuals with pre-existing vitiligo who had ever been diagnosed with vitiligo before the index year (n = 35,710) or who were diagnosed with vitiligo within a year of the index year (n = 46,476). Newly diagnosed vitiligo was identified using claims data from baseline to date of diagnosis or December 31, 2016 (n = 22,811). The development of vitiligo was compared according to self-reported smoking status by a health examination survey. the hazard ratio of vitiligo in current smokers was 0.69 (95% confidence interval; 0.65-0.72) with a reference of neversmokers after adjustment for age, sex, regular exercise, drinking status, body mass index, diabetes mellitus, hypertension, dyslipidemia, history of stroke, and history of ischemic heart diseases. the decreased risk of vitiligo in current smokers persisted after subgroup analysis of sex and age groups. The results suggested there are suppressive effects of smoking on the development of vitiligo. Further studies are needed to evaluate the mechanism of smoking on the development of vitiligo.Vitiligo is a common depigmentation skin disease with an estimated prevalence of 0.5-1% in the worldwide population 1 . Vitiligo affects all skin types and ethnic groups. The highest incidence is recorded in India (up to 8.8%) 2 , followed by Mexico (4%) 3 , Japan (1.68%) 4 , and Denmark (0.38%) 5 . The annual incidence of vitiligo in South Korea was estimated at 0.12-0.13% 6 .Vitiligo is a multifactorial disease. It is hypothesized to be mainly caused by autoimmune factors, although genetic susceptibility, oxidative stress, and cell detachment abnormalities are also suggested etiologies 7 . The autoimmune diseases vitiligo is associated with include autoimmune thyroid disorders, rheumatoid arthritis, adult-onset diabetes mellitus, pernicious anemia, and systemic lupus erythematosus 8,9 . Once vitiligo develops, it is difficult to treat and affects quality of life. Vitiligo can negatively affect social relations 10-13 . One study showed that vitiligo has an adverse effect on patient sexuality 14 , and it has been associated with pessimistic emotions such as shame, insecurity, and sadness 15 . Therefore, evaluating the preventive and risk factors for vitiligo is important.Smoking is one of the most prevalent addictive habits that affects multi-organ systems and results in several diseases. The well-known risks of smoking habits include respiratory and cardiovascular diseases. Smoking also affects the immune system and results in inflammatory reactions. Tobacco contains as many as 6,000 different components including nicotine, polycyclic aromatic hydrocarbons, tobacco glycoprotein, and some metals, many of which are considered antigenic, c...

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“…To reinforce this assertion, Sravani and colleagues found statistically significant increases in SOD and CAT levels in both the lesional and nonlesional skin of vitiligo patients compared to levels measured from the skin of healthy controls. 81 Furthermore, they found that CAT was decreased in both skin types in the patients compared to controls. The results measuring similar markers vary somewhat from study to study.…”

Section: Ros Modelmentioning

confidence: 97%