Determination of oxidation phenotype in inbred C57Bl/6 and BALB/C mice

Seredenin, S. B.; Rybina, I. V.; Khlopushina, T. G.; Zherdev, V. P.

doi:10.1007/bf00841303

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Further evidence for intrastrain differences was shown by the metabolism of antipyrine in male mice. 18 These results were similar to those observed with some 4-substituted amphetamines, where there was increased recovery of the 0-demethylation product during gestation in the mouse. 25 The results from this study are in concordance with literature reports, which suggest that there is a significant reduction or change in the activity of drug-metabolizing enzymes during pregnancy.…”

Section: Discussionsupporting

confidence: 88%

“…Many investigators have also demonstrated genetic, interspecies or interstrain, and sex-related differences in the biotransformation and toxicity of drugs. 14- 18 The rate and extent of drug metabolism are influenced by eliminati~n",'~ and on the rate of biotransformation for each metabolic pathway.20 Thus, it is quite likely that the therapeutic response to a given dose of drug may change and require dosage modifications in pregnant patients.…”

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The influence of pregnancy on the biotransformation and urinary excretion of methoxyphenamine in mice

et al. 1995

Biopharm & Drug Disp

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(i) The urinary elimination of methoxyphenamine (MPA) and its metabolites in underivatized samples was examined after single and multiple oral administration to pregnant and non-pregnant mice by GLC and GLC-MS. (ii) The major metabolite O-desmethylmethoxyphenamine (ODMP), along with lesser amounts of N-desmethylmethoxyphenamine (NDMP) and 2-hydroxyamphetamine (2OH), were the only metabolites detected in urine extracts of pregnant and non-pregnant mice. 5-Hydroxymethoxyphenamine (5HMP) was not detected. Enzyme hydrolysis did not increase the recovery of either substrate or metabolites in either the pregnant or non-pregnant animals. The results show that MPA metabolism in the Swiss-Webster mouse is distinctly different from that seen in man and other laboratory animals. (iii) The mean MPA:ODMP ratio in day-6 urine from pregnant mice after a single dose was 0.31 +/- 0.04. The NDMP:ODMP ratios were less than 0.10 in all samples. Non-pregnant mice urine had equivalent amounts of MPA, NDMP, ODMP, and 2OH after multiple dosing. (iv) While multiple dosing and pregnancy did not alter either the urinary recovery or profile of the metabolites detected, there was a linear decrease in the MPA:ODMP ratio during gestation. (v) MPA was extensively metabolized to ODMP in the male mice, and the MPA:ODMP ratio of 0.41 was slightly higher than that observed in the pregnant and non-pregnant females.

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Section: Discussionsupporting

confidence: 88%

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confidence: 99%

The influence of pregnancy on the biotransformation and urinary excretion of methoxyphenamine in mice

et al. 1995

Biopharm & Drug Disp

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Optimization of the system for genetic-embryological studies of inbred mice strains. 2. Comparative characterization of season female fertility of BALB/cLac, C57BL/6j and ICR mice

1992

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Клітинна біологія УДК 591 Л. Μ. Морозова, Μ. Ρ. Століна, О. П. Соломко ОПТИМІЗАЦІЯ СИСТЕМИ ДЛЯ ПРОВЕДЕННЯ ГЕНЕТИКО-ЕМБРІОЛОГІЧНИХ ДОСЛІДЖЕНЬ НА ІНБРЕДНИХ ЛІНІЯХ МИШЕЙ. 2. ПОРІВНЯННЯ ЗДАТНОСТІ ДО ЗАПЛІДНЕННЯ IN VITRO ІНБРЕДНИХ ЛІНІЙ МИШЕЙ C57BL/6j I BALB/cLac Вивчено можливість оптимізації біологічної системи для запліднення in vitro без попередньої гормональної стимуляції лінійних донорів гамет. Обрано культуральне середовище для фертилізації in vitro, оптимальне, як мінімум, для двох контрастових за багатьма характеристиками інбредних ліній мишей C57BLj6/ і BALB/cLac. Показано домінуючу роль батьківського генотипу у процесі запліднення in vitro та материнськогопід час розвитку зародків у культурі аж до пізніх доімплантаційних стадій. Використання чоловічих гамет C57BL збільшує ефективність запліднення in vitro від 50 до 76 %, а наявність такого материнського генотипу забезпечує успішний розвиток до бластоцист 90 % лінійних і гібридних зародків.

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Determination of oxidation phenotype in inbred C57Bl/6 and BALB/C mice

Cited by 2 publications

References 6 publications

The influence of pregnancy on the biotransformation and urinary excretion of methoxyphenamine in mice

The influence of pregnancy on the biotransformation and urinary excretion of methoxyphenamine in mice

Optimization of the system for genetic-embryological studies of inbred mice strains. 2. Comparative characterization of season female fertility of BALB/cLac, C57BL/6j and ICR mice

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