Determination of oxalic acid in herbal medicines by semi-micro hydrophilic interaction liquid chromatography coupled with electrochemical detection

Kotani, Akio; Ishikawa, Hisanobu; Shii, Takashi; Kuroda, Minpei; Mimaki, Yoshihiro; Machida, Koichi; Yamamoto, Kazuhiro; Hakamata, Hideki

doi:10.1007/s44211-022-00245-w

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…In 2023, Kotani et al used semi-micro hydrophilic interaction liquid chromatography coupled with electrochemical detection (HILIC-ECD) to quantify oxalate in herbal products used in traditional Kampo medicine [ 42 ]. Kampo is the study of traditional Chinese medicine in Japan.…”

Section: Methods For Detection and Quantification Of Oxalatementioning

confidence: 99%

Analytical Methods for Oxalate Quantification: The Ubiquitous Organic Anion

et al. 2023

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Oxalate is a divalent organic anion that affects many biological and commercial processes. It is derived from plant sources, such as spinach, rhubarb, tea, cacao, nuts, and beans, and therefore is commonly found in raw or processed food products. Oxalate can also be made endogenously by humans and other mammals as a byproduct of hepatic enzymatic reactions. It is theorized that plants use oxalate to store calcium and protect against herbivory. Clinically, oxalate is best known to be a major component of kidney stones, which commonly contain calcium oxalate crystals. Oxalate can induce an inflammatory response that decreases the immune system’s ability to remove renal crystals. When formulated with platinum as oxaliplatin (an anticancer drug), oxalate has been proposed to cause neurotoxicity and nerve pain. There are many sectors of industry that are hampered by oxalate, and others that depend on it. For example, calcium oxalate is troublesome in the pulp industry and the alumina industry as it deposits on machinery. On the other hand, oxalate is a common active component of rust removal and cleaning products. Due to its ubiquity, there is interest in developing efficient methods to quantify oxalate. Over the past four decades, many diverse methods have been reported. These approaches include electrochemical detection, liquid chromatography or gas chromatography coupled with mass spectrometry, enzymatic degradation of oxalate with oxalate oxidase and detection of hydrogen peroxide produced, and indicator displacement-based methods employing fluorescent or UV light-absorbing compounds. Enhancements in sensitivity have been reported for both electrochemical and mass-spectrometry-based methods as recently as this year. Indicator-based methods have realized a surge in interest that continues to date. The diversity of these approaches, in terms of instrumentation, sample preparation, and sensitivity, has made it clear that no single method will work best for every purpose. This review describes the strengths and limitations of each method, and may serve as a reference for investigators to decide which approach is most suitable for their work.

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Section: Methods For Detection and Quantification Of Oxalatementioning

confidence: 99%

Analytical Methods for Oxalate Quantification: The Ubiquitous Organic Anion

et al. 2023

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Efficient Quantification of Soluble and Insoluble Oxalates in Clay Mineral Mixtures

Nel,

Clarke,

Francis

et al. 2024

Communications in Soil Science and Plant Analysis

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Oxalate and oxalotrophy: an environmental perspective

Cowan,

Babenko,

Bird

et al. 2024

Sustainable Microbiology

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Oxalic acid is one of the most abundant organic acids produced by plants. Much of the global production of oxalic acid is deposited on soil surfaces in leaf litter, to be oxidised by microorganisms, resulting in a pH increase and shifting the carbonate equilibria. In what is known as the oxalate-carbonate pathway, calcium oxalate metabolism results in CO2 being sequestered into soils as insoluble calcite (CaCO3). There is a growing appreciation that the global scale of this process is sufficiently large to be an important contribution to global carbon turnover budgets. The microbiomics, genetics and enzymology of oxalotrophy are all soundly established, although a more detailed understanding of the landscape-scale kinetics of the process would be needed to incorporate oxalotrophy as an element of process models informing the relevant Sustainable Development Goals. Here, we review the current state of knowledge of oxalotrophs and oxalotrophy and the role they play in terrestrial ecosystem services and functions in terms of carbon sequestration and nutrient cycling. We emphasize the relevance of these to the Sustainability Development Goals (SDGs) and highlight the importance of recognising oxalotrophy when accounting for the natural capital value of an ecosystem.

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Determination of oxalic acid in herbal medicines by semi-micro hydrophilic interaction liquid chromatography coupled with electrochemical detection

Cited by 3 publications

References 20 publications

Analytical Methods for Oxalate Quantification: The Ubiquitous Organic Anion

Analytical Methods for Oxalate Quantification: The Ubiquitous Organic Anion

Efficient Quantification of Soluble and Insoluble Oxalates in Clay Mineral Mixtures

Oxalate and oxalotrophy: an environmental perspective

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