Determination of organophosphate flame retardants and plasticizers in lipid-rich matrices using dispersive solid-phase extraction as a sample cleanup step and ultra-high performance liquid chromatography with atmospheric pressure chemical ionization mass spectrometry

Chu, Shi-Jye; Letcher, Robert J.

doi:10.1016/j.aca.2015.05.024

Cited by 51 publications

(36 citation statements)

References 31 publications

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“…The instrumental LODs were between 0.1 and 0.6 ng/mL (0.5 and 3 injected pg), and instrumental LOQs were between 0.4 and 1.9 ng/mL (2 and 9.5 injected ng) (Supporting Information Table S3). These values were similar to those reported when determining PFRs by LC–MS/MS elsewhere .…”

Section: Resultssupporting

confidence: 89%

Determination of organophosphate flame retardants in soil and fish using ultrasound‐assisted extraction, solid‐phase clean‐up, and liquid chromatography with tandem mass spectrometry

Lorenzo

Campo

Picó

2018

J of Separation Science

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A solid-liquid extraction method in combination with high-performance liquid chromatography and tandem mass spectrometry was developed and optimized for extraction and analysis of organophosphorus flame retardants in soil and fish. Methanol was chosen as the optimum extraction solvent, not only in terms of extraction efficiency, but also for its broader analyte coverage. The subsequent clean-up by solid-phase extraction is required to eliminate matrix coextractives and reduce matrix effects. Recoveries of the optimized method were 50-121% for soil and 47-123% for biota, both with high precision (RSDs <12% in soil and <23% in biota). The method limits of detection ranged from 0.06 to 0.20 ng/g dry weight and between 0.02 and 0.30 ng/g wet weight for soil and biota samples, respectively. However, samples with a high lipid content produce several problems as solid-phase extraction cartridge clogging that increase variability and analysis time. The method was successfully applied for the determination of organophosphorus flame retardants in soil and fish from L'Albufera Natural Park (Valencia, Spain). Target compounds were detected in all soil and fish samples with values varying from 13.8 to 89.7 ng/g dry weight and from 3.3 to 53.0 ng/g wet weight, respectively.

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Section: Resultssupporting

confidence: 89%

Determination of organophosphate flame retardants in soil and fish using ultrasound‐assisted extraction, solid‐phase clean‐up, and liquid chromatography with tandem mass spectrometry

Lorenzo

Campo

Picó

2018

J of Separation Science

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“…Chen et al (2012) reported low levels of EHDPHP (<0.09e0.17 ng/ g ww), TBOEP (0.16e2.2 ng/g ww), TCEP (<0.10e0.55 ng/g ww) and TCPP (<0.20e4.1 ng/g ww) in herring gull eggs from the ChannelShelter Island (Lake Huron, US) in 2010, while TEHP and TPHP were not detected. In another study about herring gull eggs from the Great Lakes basin during 2013, TCEP was detected in 58% of samples (max 13 ng/g ww) (Chu and Letcher, 2015). In free-range chicken eggs from the Belgium market, only TPHP (0.27 ng/g ww) could be found .…”

Section: Levels Of Target Frs In Home-produced Eggsmentioning

confidence: 99%

Phosphate flame retardants and novel brominated flame retardants in home-produced eggs from an e-waste recycling region in China

Zheng

Luo

et al. 2016

Chemosphere

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h i g h l i g h t sEH-TBB, BEH-TEBP and PFRs were measured in free-range chicken eggs. Chlorinated PFRs had higher detection frequencies than non-chlorinated PFRs in eggs. TPHP had a higher detection frequency in albumen; BEH-TEBP was higher in yolks. Dust ingestion is a more important pathway than egg intake in human exposure to PFRs. a r t i c l e i n f o b s t r a c tPhosphate flame retardants (PFRs) and novel brominated flame retardants (NBFRs) (2-ethylhexyl-2,3,4,5-tetrabromo-benzoate (EH-TBB) and bis-(2-ethylhexyl)-3,4,5,6-tetrabromo-phthalate (BEH-TEBP)) were measured in free-range chicken eggs from three e-waste recycling sites and a negative control site located in Guangdong province, Southern China. BEH-TEBP, tris-(chloroethyl)-phosphate (TCEP), tris-(chloropropyl)-phosphate ( P TCPP, two isomers) and tris-(1,3-dichloroisopropyl)-phosphate (TDCIPP) were detected in more than 50% of eggs samples with low concentrations. The median values of BEH-TEBP and total PFRs were 0.17e0.46 ng/g ww (wet weight) and 1.62e2.59 ng/g ww in eggs from the e-waste sites, respectively. The results indicate that EH-TBB, BEH-TEBP and PFRs are less persistent and bioaccumulative than polybrominated diphenyl ethers (PBDEs) in chicken eggs, and possibly also in other bio-matrices. Triphenyl phosphate (TPHP) were identified in albumen with higher frequencies, but at similar concentrations compared to yolk, while BEH-TEBP was mainly detected in yolk. The estimated daily intake (EDI) of BEH-TEBP and total PFRs from consumption of chicken eggs ranged from 0.03 to 0.09 and 0.32e0.52 ng/kg bw/day for adults, and 0.20e0.54 and 1.89e3.02 ng/kg bw/day for children in ewaste sites, respectively. Indoor dust ingestion seems to be a more important pathway for the intake of these FRs, while egg consumption is probably a more important exposure pathway for PBDEs.

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“…The common instruments utilized for the determination of PFRs include gas chromatography (GC), GC coupled to mass spectrometry (GCMS), and liquid chromatography–tandem mass spectrometry (LC–MS/MS) . Although GC and GCMS are still the major technologies for the detection of PFRs, the requirement of pretreatment and matrix interference have limited their application .…”

Section: Introductionmentioning

confidence: 99%

Accelerated solvent extraction coupled to high‐performance liquid chromatography–tandem mass spectrometry for simultaneous determination of 11 organophosphorus flame retardants in aquatic products

et al. 2018

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Determination of organophosphate flame retardants and plasticizers in lipid-rich matrices using dispersive solid-phase extraction as a sample cleanup step and ultra-high performance liquid chromatography with atmospheric pressure chemical ionization mass spectrometry

Cited by 51 publications

References 31 publications

Determination of organophosphate flame retardants in soil and fish using ultrasound‐assisted extraction, solid‐phase clean‐up, and liquid chromatography with tandem mass spectrometry

Determination of organophosphate flame retardants in soil and fish using ultrasound‐assisted extraction, solid‐phase clean‐up, and liquid chromatography with tandem mass spectrometry

Phosphate flame retardants and novel brominated flame retardants in home-produced eggs from an e-waste recycling region in China

Accelerated solvent extraction coupled to high‐performance liquid chromatography–tandem mass spectrometry for simultaneous determination of 11 organophosphorus flame retardants in aquatic products

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