Determination of organic compounds in human hair

Bogdanov, Alexey V.; Glazkov, I. N.; Polenova, T. V.; Marutsenko, I. V.; Revel'skii, I. A.

doi:10.1134/s1061934806100029

Cited by 12 publications

(4 citation statements)

References 131 publications

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“…If, however, the third quadrupole is set up to work in SIM mode with low mass resolution and uniformly transfer all of the masses of the product ion, a scan of the first quadrupole around the molecular ion group of isotopomers will generate the true, nascent isotope abundance of the molecular ions. As is known [2][3][4][5][6][7][8][9][10][11][12][13] such isotope abundance can be used to derive possible elemental formulae with declining order of matching to the experimental data.…”

Section: The Isotope Abundance Analysis Ms/ms Methodsmentioning

confidence: 99%

“…We recently developed a new isotope abundance analysis (IAA) method and software 2,3 which we named Tal-Aviv. Various forms of IAA have also been described by several other authors [4][5][6][7][8][9][10][11][12][13] The Tal-Aviv IAA software is used to derive elemental formula information from experimental mass spectral data of molecular ion isotopomeric abundances. The software can also be used to automatically confirm or reject the search results coming from an EI spectral library search application such as NIST (National Institute of Standards and Technology), 14 thereby significantly improving the confidence level in sample identifications.…”

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confidence: 99%

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Isotope abundance analysis for improved sample identification with tandem mass spectrometry

Alon¹,

Amirav²

2009

Rapid Comm Mass Spectrometry

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Tandem mass spectrometry (MS/MS) is widely used for trace level sample analysis in complex mixtures. However, sample identification in MS/MS is challenging and not as trustworthy as with electron ionization (EI) mass spectral libraries. This paper presents a novel method for the combination of isotope abundance analysis (IAA) and EI-MS/MS for improved sample identification even at trace level in complex matrices. Accordingly, the first quadrupole is scanned in a narrow range around the molecular ion group of isotopomers such as M+, [M+1]+ and [M+2]+, Q2 serves for collision-induced dissociation to produce product ions while Q3 transfers the major sample product ions with low resolution, thus encompassing and uniformly transmitting all the product ion isotopomers. IAA can then be used to derive elemental formula information from the cleansed experimental data. IAA-MS/MS was experimentally tested with perfluorotributylamine and a very good matching factor of 995 (out of 1000) was obtained for IAA on m/z 502, 503 and 504 (fragment ion isotopomers) while Q3 transmitted the m/z 264 product ion with a mass window of 6 m/z units. The IAA-MS/MS method was further tested with the pesticide diazinon on its molecular ions m/z 304, 305 and 306 while Q3 was locked on its m/z 179 product ion with a mass window of 6 m/z units. Again, very good matching factors were obtained, even for 40 pg diazinon on-column during its GC/MS analysis (match = 981). IAA-MS/MS combines the traditional benefits of MS/MS in the removal of matrix interferences with the IAA power of elemental analysis.

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Section: The Isotope Abundance Analysis Ms/ms Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Isotope abundance analysis for improved sample identification with tandem mass spectrometry

Alon¹,

Amirav²

2009

Rapid Comm Mass Spectrometry

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“…Chemicals may also be absorbed from the outside by using haircare products, for example, leading to the contamination of the hair as a sample matrix. Since hair is a non-viable biological matrix in which biological processes no longer take place, parameters can be detected for many months or even years, depending on hair length (Bogdanov et al 2006). Hair has already been used in HBM for the determination of brominated flame retardants (Liang et al 2016 ;Poon et al 2014 ;Zhao et al 2020), pesticides (Park et al 2021 ;Polledri et al 2021), per-and polyfluoroalkyl substances (Piva et al 2021 ;Ruan et al 2019), and polycyclic aromatic hydrocarbons (Schummer et al 2009 ;Toriba et al 2003), to cite a few examples.…”

Section: Biological Matricesmentioning

confidence: 99%

Human metabolism and biomonitoring of 2‐(5‐chloro‐benzotriazol‐2‐yl)‐4,6‐di‐(tert‐butyl)phenol (UV‐327)

Fischer,

Pischetsrieder,

Göen

2024

Lebensmittelchemie

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“…Collecting samples of hair is safe for human health, and preliminary studies of hair can involve large groups of subjects. However, there is one important peculiarity of hair-its ability to absorb endogenic substances from a human organism and preserve them in a practically invariable state for an extended length of time (ranging from several months to several years) [10,11].…”

Section: Introductionmentioning

confidence: 99%

Biomonitoring of organic and inorganic chemicals in the hair of Vietnamese people via spectral and chromatographic analysis

Cuong¹,

Thuy²,

Evgen'ev³

2013

JBPC

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A combination of spectral and chromatographic analytical methods has been executed to monitor chemicals in the hair of Vietnamese people. Methods were developed for the determination of some chemical elements in hair by inductively coupled-plasma atomic emission spectroscopy with limits of detection reaching 1 - 100 μg·l^－¹. A supercritical fluid extraction (SFE) and clean-up procedures were established for isolating organochlorine pollutants (OCPs) and organophosphorus pesticides (OPPs) from the hair of the Vietnamese test subjects. Eight OCPs and OPPs were determined by SFE with carbon dioxide only and methanol-modified carbon dioxide extraction at 350 bar and 45℃, followed by gas chromatography coupled to mass spectrometry. The results indicated that OCPs can be extracted quantitatively using CO₂ only, whereas OPPs require a modifier for extraction. The limits of detection that were found were between 0.7 to 1.3 μg·g^－¹, and good linearity (r² > 0.9861) was achieved within the tested ranges. The activities of the N-acetyltransferase (NAT) and the monooxygenases cytochrome P450 (CYP 450) were determined and compared to the acetylation and oxidation phenotypes of healthy Vietnamese test subjects. The variations in the concentration of chemical elements in human hair were shown to be dependent upon the activities of the two-phase metabolic system, on the individual’s gender and the duration of residence within Russia.

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Determination of organic compounds in human hair

Cited by 12 publications

References 131 publications

Isotope abundance analysis for improved sample identification with tandem mass spectrometry

Isotope abundance analysis for improved sample identification with tandem mass spectrometry

Human metabolism and biomonitoring of 2‐(5‐chloro‐benzotriazol‐2‐yl)‐4,6‐di‐(tert‐butyl)phenol (UV‐327)

Biomonitoring of organic and inorganic chemicals in the hair of Vietnamese people via spectral and chromatographic analysis

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