Determination of Optical Properties and Photodynamic Threshold of Lung Tissue for Treatment Planning of In Vivo Lung Perfusion Assisted Photodynamic Therapy

Photobleaching Kinetics and Effect of Solvent in the Photophysical Properties of Indocyanine Green for Photodynamic Therapy

“…Where $${{F}_{ex}(0,\lambda )}$$ is the intensity, $${\lambda }$$ wavelength, $${h}$$ Planck constant and $${c}$$ speed of light. Then, using the absorption coefficient at the respective wavelength, the absorbed photons were calculated, $${{h\nu }_{abs}={\mu }_{a}\left(\lambda \right){h\nu }_{emi}}$$ . Where $${{\mu }_{a}\left(\lambda \right)}$$ is the absorption coefficient. The dose of absorbed photons was used as the fixed parameter, $${1\times {10}^{19}\ h\nu /{cm}^{3}}$$ , which is a threshold energy dose described in the literature for a PDT effect [38,39] . After that, $${{t}_{i}={{1\times {10}^{19}}\over{{h\nu }_{abs}}}}$$ .…”

“…The dose of absorbed photons was used as the fixed parameter, 1 � 10 19 hn=cm 3 , which is a threshold energy dose described in the literature for a PDT effect. [38,39] After that, t i ¼ 1�10 19 hn abs . Subsequently, the samples were placed in front of the devices and the absorbance spectra were measured at different irradiation times, as a function of absorbed photons.…”

Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE

“…FullMonteSW 5 performs Monte Carlo simulations of light propagation within 3D biomaterials of arbitrary shapes and tissue types to evaluate PDT treatment plans as well as for other light propagation studies in clinical 16 and preclinical research. 27 , 28 The tool simulates the light propagation by tracing a user-specified number of photon packets 29 and aggregating statistics on photon absorption throughout the volume. It supports a variety of light sources, including point sources, radially emitting fibers, cut-end fibers emitting in a cone, arbitrary surface emitters, and combinations of these.…”

“…For plan evaluation, we simulate three different meshes: a bladder mesh 16 with a single point light source, the Colin27 brain atlas 35 (a low-resolution human brain mesh) with 1 point light source, and a high-resolution pig lung mesh—taken from Ramadan et al. 28 —with light emitted from a complex surface source. Figure 10 shows a visualization of the three meshes.…”

Photodynamic inactivation ofStreptococcus pneumoniaewith external illumination at 808 nm through the ex vivo porcine thoracic cage

“…At the same time, the light attenuation caused by scattering and absorption cannot be excessive to the point of making the delivered light dose within the target tissue insufficient. Recently, Remadan et al [17] presented a study of the optical properties and photodynamic threshold energy dose of lung tissue with three different wavelengths (525, 665 and 808 nm) showing the importance of photon migration modeling for the correct use of PDT protocols.…”