Determination of Olopatadine in Human Tears by Hydrophilic Interaction Liquid Chromatography–MS/MS Method

Abstract

The proposed method was utilized for monitoring of olopatadine in human tear.

Electro‐elucidation and quantification of olopatadine hydrochloride in bulk form and eye drops using modification free glassy carbon electrode with its development by different electrolytes and surfactants

“…So, it is an advantageous therapeutic for the most allergic diseases (allergic conjunctivitis known as itching eyes, rhinitis, chronic urticaria, eczema and dermatitis) [3]. As well, possessing inhibitory influence on the release of inflammatory lipid mediators [4].…”

“…Few analytical methods have been reported for the determination of OPH in pharmaceutical formulations and human biological fluids. These include HILC-MS/ MS [3,7], HPTLC [8], RP-HPLC [9][10][11], HPLC-ESI-MS/ MS [12,13], HPLC-MS/TOF [14], potentiometric sensor [15], UV-vis [6,[16][17][18][19][20][21]. The reported chromatographic and spectroscopic tools have many disadvantages such as sample pretreatment, time consuming, expensive apparatus and reagents.…”

Green and sensitive detection of olopatadine in aqueous humor using a signal‐on fluorimetric approach: GREEnness assessment

“…This drug comes in the form of eye drops and is commonly prescribed to relieve symptoms such as itching, redness, and watering of the eyes caused by allergies like hay fever or allergic conjunctivitis [20–22]. Most of the detection approaches for OLP are chromatographic approaches [23–33]. While these methods provide outstanding detection limits and the capability to analyze OLP degradation by‐products, their use is constrained by time‐intensive procedures, extended pretreatment steps of the designated compounds or drug, and the need for exceptionally high‐purity solvents, along with a requirement for skilled personnel.…”