Determination of nitrofuran metabolites in meat products by UHPLC-fluorescence with ultrasonic-assisted derivatization

Synthesis and radiolabeling of a nitrofuran derivate with >sup<18>/sup<F for identification of areas of hypoxia in the tumor microenvironment

“…Chapman and colleagues in 1972 [37] reported the first work about mammalian cell sensitization by nitrofurans such as nifurtimox, nitrofurantoin, nitrofurazone, and nifuroxime (Figure 12), proving that these nitroaromatic compounds could be also used as sensitizers. This was particularly significant since these compounds were already in clinical use (and have been for more than 50 years) as antibacterial agents and antibiotics, therefore considerable information on their toxicology, pharmacology and conditions this hydrazone bond is rapidly hydrolyzed [106], giving side-chain metabolites that covalently binds to cellular proteins and persists in vivo for a certain time period, and is also responsible for toxic properties, such as carcinogenicity and mutagenicity [106,107].…”