Determination of nerve agent biomarkers in human urine by a natural hydrophobic deep eutectic solvent-parallel artificial liquid membrane extraction technique

Bouchouareb, Khirreddine; Combès, Audrey; Pichon, Valérie

doi:10.1016/j.talanta.2022.123704

Cited by 10 publications

(1 citation statement)

References 63 publications

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“…25-100 μl) consumption, as well as the possibility of simultaneous extraction of multiple samples and nice prospects of automation. These features make this technique a reliable approach for bioanalysis and, consequently, has been recently employed for it [122][123][124].…”

Section: Membrane-based Liquid Phase Microextractionmentioning

confidence: 99%

Ultramicroextraction as a miniaturization of the already miniaturized. A step toward nanoextraction and beyond

Azorín

Benedé

Chisvert

2023

J of Separation Science

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Miniaturization of the analytical process has been a widespread trend, and the sample preparation stage is not exempted from this downscaling. Since the introduction of microextraction techniques as miniaturization of classical extraction techniques, they have become one of the strengths in this field. However, some of the original approaches to these techniques did not fully cover all the current principles of Green Analytical Chemistry. For this reason, during the last years, much emphasis has been placed on reducing/eliminating toxic reagents, reducing the amount of the extraction phase, and searching for new greener, and more selective extractant materials. On the other hand, even though high accomplishments have been achieved, the same attention has not always been paid to reducing the amount of sample, which is essential when treating low‐availability samples such as biological samples, or in developing portable devices. In this review, we intend to give the readership an overview of the advances toward further miniaturization of microextraction techniques. Finally, a brief reflection is made on the terminology used, or that should, in our opinion, be used to term these new generation of miniaturized microextraction approaches. To this regard, the term, ‘ultramicroextraction’ is proposed to refer to those approaches beyond microextraction.

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Section: Membrane-based Liquid Phase Microextractionmentioning

confidence: 99%

Ultramicroextraction as a miniaturization of the already miniaturized. A step toward nanoextraction and beyond

Azorín

Benedé

Chisvert

2023

J of Separation Science

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High-throughput platforms for microextraction techniques

Merib

2023

Anal Bioanal Chem

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Development of a molecularly imprinted polymer-based electrochemical sensor for the selective detection of nerve agent VX metabolite ethyl methylphosphonic acid in human plasma and urine samples

Sezigen,

Kaya,

Bakirhan

et al. 2024

Anal Bioanal Chem

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This study focuses on the detection of ethyl methyl phosphonic acid (EMPA), a metabolite of the banned organophosphorus nerve agent VX. We developed an electrochemical sensor utilizing the molecularly imprinted polymer (MIP) based on 4-aminobenzoic acid (4-ABA) and tetraethyl orthosilicate for the selective detection of EMPA in human plasma and urine samples. The 4-ABA@EMPA/MIP/GCE sensor was constructed by a thermal polymerization process on a glassy carbon electrode and sensor characterization was performed by cyclic voltammetry and electrochemical impedance spectroscopy. The 4-ABA@EMPA/MIP/GCE sensor demonstrated impressive linear ranges 1.0 × 10–10 M–2.5 × 10–9 M for the standard solution, 1.0 × 10–10 M–2.5 × 10–9 M for the urine sample, and 1.0 × 10–10 M–1 × 10–9 M of EMPA for the plasma sample with outstanding detection limits of 2.75 × 10−11 M (standard solution), 2.11 × 10−11 M (urine), and 2.36 × 10−11 M (plasma). The sensor exhibited excellent recovery percentages ranging from 99.86 to 101.30% in urine samples and 100.62 to 101.08% in plasma samples. These findings underscore the effectiveness of the 4-ABA@EMPA/MIP/GCE as a straightforward, highly sensitive, and selective interface capable of detecting the target analyte EMPA in human plasma and urine samples.

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Determination of nerve agent biomarkers in human urine by a natural hydrophobic deep eutectic solvent-parallel artificial liquid membrane extraction technique

Cited by 10 publications

References 63 publications

Ultramicroextraction as a miniaturization of the already miniaturized. A step toward nanoextraction and beyond

Ultramicroextraction as a miniaturization of the already miniaturized. A step toward nanoextraction and beyond

High-throughput platforms for microextraction techniques

Development of a molecularly imprinted polymer-based electrochemical sensor for the selective detection of nerve agent VX metabolite ethyl methylphosphonic acid in human plasma and urine samples

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