“…Several assays have been reported for the analysis of MPA and its metabolites by LC-MS/MS in different matrices (Benech et al, 2007;Brandhorst et al, 2006;Delavenne et al, 2011;Heinig et al, 2010;Kawanishi et al, 2015;Klepacki et al, 2012;Kuhn et al, 2009;Laverdiere et al, 2012;Md Dom et al, 2014;Shen et al, 2009;Upadhyay et al, 2014;Wiesen et al, 2012). However, relatively few assays are available for simultaneous quantification of MPA and its glucuronide metabolites with sufficient sensitivity for AcMPAG, which has a relatively low abundance in comparison with MPAG.…”