Determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in monkey and dog plasma by high-performance liquid chromatography–electrospray ionization tandem mass spectrometry

Recent studies on the electrospray ionisation mass spectrometric behaviour of selected nitrogen-containing drug molecules and its application to drug analysis using liquid chromatography–electrospray ionisation mass spectrometry

“…A specific and simultaneous assay of morphine, morphine-3-glucuronide (M-3-G) and morphine-6-glucuronide (M-6-G) in monkey and dog plasma has been developed [48]. These methods were based on rapid isolation using SPE and then LC-ESI-MS/MS.…”

Analysis of opioids in postmortem urine samples by dispersive liquid-liquid microextraction and high performance liquid chromatography with photo diode array detection

“…A fast, easy and effective method for sample preparation is a key role for achieving to the better analytical procedures. Some traditional analytical techniques such as liquid-liquid extraction (LLE) and solid-phase extraction (SPE) have been developed for extraction and determination of drugs including opioids in biological specimens (Wey and Thorman 2001;Whittington and Kharasch 2003;Mabuchi et al 2004). There are some limitations on using of these methods of sample preparation.…”

Fabrication of electrochemical sensor based on molecularly imprinted polymer and nanoparticles for determination trace amounts of morphine

“…So far, several methods of analytical techniques have been reported to determine MO concentrations such as highperformance liquid chromatography (HPLC) [7,8], liquid chromatography with UV detection [9,10], GC-mass spectroscopy [11][12][13][14], LC-mass spectrometry detection [15], and electrochemical methods [16][17][18][19][20]. However, some of these techniques are time consuming, contain interferences of matrix, use large biological fluid volumes, and need expensive instruments and toxic solvents, and in some cases, special pretreatment is required before analysis.…”