Determination of Mn-BOPP Concentrations Using Neutron Activation Analysis and MRI

Combs, Matthew J.; Mulder, Robert U.; Berr, Stuart S.; Oveissi, C.; Kahl, Stephen B.

doi:10.1007/978-1-4757-9567-7_35

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Porphyrins and Phthalocyanines1

Scheme 181

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2001

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“…They pre- pared tetracarboranylporphyrins having four closoor nido-carborane moieties attached directly or via methylene or aromatic linkages to the porphyrin nucleus. Their work led to major efforts independently and jointly by Kahl, [388][389][390][391][392][393][394][395][396][397][398][399][400][401][402][403][404] Miura, [405][406][407][408][409][410][411] and Gabel 346,[412][413][414][415][416] and their associates in the development of water-soluble, boron-containing porphyrins for BNCT (Figure 34). More recently, they have been joined by Phadke and Morgan.…”

Section: Porphyrins and Phthalocyaninesmentioning

confidence: 99%

The Chemistry of Neutron Capture Therapy

et al. 1998

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Section: Porphyrins and Phthalocyaninesmentioning

confidence: 99%

The Chemistry of Neutron Capture Therapy

et al. 1998

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“…The manganese(III) chelate of porpyrin 39 (Mn-BOPP) [31,64] and 2-dodecaboranylthiocarbamoylmethyl-4-vinyl-deuteroporphinato manganese(III) complex [39,65] were shown to serve simultaneously as BNCT agents and as contrast agents for magnetic resonance imaging (MRI) of brain tumors.…”

Section: Scheme 18mentioning

confidence: 99%

Polyhedral boron derivatives of porphyrins and phthalocyanines

Bregadze

Sivaev

Gabel

et al. 2001

J. Porphyrins Phthalocyanines

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ABSTRACT:The synthesis of compounds containing polyhedral boron cages and porphyrin or phthalocyanine units connected covalently in one molecule is reviewed. The importance of these compounds arises, on the one hand, from the use of polyhedral boron derivatives in neutron capture therapy for cancer; on the other hand, porphyrins and phthalocyanines are known as photosensitizers in photodynamic tumor therapy. Current interest in the binding of polyhedral boron compounds to porphyrins and phthalocyanines is due to the observation that porphyrins and phthalocyanines show improved uptake and good persistence in tissues. Medical applications of compounds containing polyhedral boron cages and porphyrin or phthalocyanine units in one molecule are briefly discussed.

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Determination of Mn-BOPP Concentrations Using Neutron Activation Analysis and MRI

Cited by 2 publications

References 2 publications

The Chemistry of Neutron Capture Therapy

The Chemistry of Neutron Capture Therapy

Polyhedral boron derivatives of porphyrins and phthalocyanines

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