Determination of methylisothiazolinone in waters. Comprehensive study about electrochemical behaviour on gold electrode and optimization of square-wave voltammetric methods

Abad-Gil, Lucía; Gismera, Ma Jesús; Sevilla, Ma Teresa; Procopio, Jesús R.

doi:10.1016/j.jelechem.2020.114831

Cited by 5 publications

(13 citation statements)

References 34 publications

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“…A promising technique to identify the target species is to develop chemical receptors (CRs) that can selectively recognize these molecules. 15 Considering these aspects, this study was aimed at synthesizing CRs to recognize biocides and evaluating their sensing capability by using an electrochemical method. Numerical calculations were performed to screen CR candidates consisting of imidazolium derivatives with various functional groups, and five structures were selected to be synthesized.…”

Section: Introductionmentioning

confidence: 99%

“…Chemicals such as ITZs are typically identified using sophisticated instruments and complicated procedure . The most commonly used technique to identify ITZs involves liquid chromatography coupled with mass spectrometry. , The Procopio group investigated the electrochemical behavior of an ITZ derivative (methyl-ITZ) as a function of its concentration on a gold electrode. However, this technique is highly unstable in the presence of interferences.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the similarity in molecular structures makes it difficult to selectively differentiate the derivatives by using a sensing tool. A promising technique to identify the target species is to develop chemical receptors (CRs) that can selectively recognize these molecules …”

Section: Introductionmentioning

confidence: 99%

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Graphene Functionalized with Imidazole Derivatives as Nanotransducers for Electrochemically Detecting Isothiazolinone Biocides

Lee

Chae

et al. 2022

ACS Appl. Nano Mater.

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Isothiazolinones, which are widely used as chemical additives in many industries, may lead to skin irritation and allergies, thereby adversely influencing human health and the environment. Therefore, this paper proposes an efficient strategy for screening nanohybrid transducers to selectively detect 2-octyl-3-isothiazolinone (OIT) as a representative isothiazolinone. Chemical receptor (CR) candidates consisting of two parts: a reactive imidazole unit and side functional group for covalent conjugation with graphene and noncovalent interaction with the target, respectively, were designed. Five CR structures were selected and synthesized based on density-functional-theory calculations. The synthesized CRs were anchored to graphene for electrochemical transduction. The alkyl groups calculated to have the highest chemical affinities toward OIT were introduced in the CR/graphene nanohybrids (CGNHs). The electrochemical responses of the CGNHs toward OIT depended on the CR type, OIT concentration, and applied potential. Therefore, the combination of five CGNHs as a transducer with different potentials enabled the facile and effective detection of OIT (1–200 mg L–1) from the interferences through principal component analyses. The best CR corresponded to the dodecyloxy group, and the optimal measurement conditions included a scan rate of 25 mV s–1 and applied potentials of −0.75, 0.08, and 1.30 V (vs Ag/AgNO3). The proposed strategy can facilitate the efficient development of nanotransducers for identifying different types of chemical species such as biocides.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Graphene Functionalized with Imidazole Derivatives as Nanotransducers for Electrochemically Detecting Isothiazolinone Biocides

Lee

Chae

et al. 2022

ACS Appl. Nano Mater.

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“…To our knowledge, only one method for the determination of MIT by HPLC coupled with electrochemical detection (ECD) has been developed to date. Abad-Gil et al [33] used their previous studies on the voltammetric determination of MIT with a the gold electrode [34] to develop a procedure for the simultaneous chromatographic determination of antimicrobial agents in cosmetics. The LOD value of 30 µg L −1 obtained for MIT is lower than those previously reported for HPLC with UV detectors [2,21,29,30] and comparable for MS/MS [1].…”

Section: Introductionmentioning

confidence: 99%

“…They do not require expensive equipment, and sample preparation is often limited to dissolving a sample in a suitable medium. They are equal in sensitivity and precision to chromatographic techniques [34,35].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Characterization and Voltammetric Determination of Methylisothiazolinone on a Boron-Doped Diamond Electrode

et al. 2022

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The electrochemical properties of methylisothiazolinone (MIT), the most widely used preservative, were investigated by cyclic (CV) and differential pulse voltammetry (DPV) to develop a new method for its determination. To our knowledge, this is the first demonstration of a voltammetric procedure for the determination of MIT on a boron-doped diamond electrode (BDDE) in a citrate–phosphate buffer (C-PB) environment. The anodic oxidation process of methylisothiazolinone, which is the basis of this method, proved to be diffusion-controlled and proceeded with an irreversible two-electron exchange. The radical cations, as unstable primary products, were converted in subsequent chemical reactions to sulfoxides and sulfones, and finally to more stable final products. Performed determinations were based on the DPV technique. A linear calibration curve was obtained in the concentration range from 0.7 to 18.7 mg L−1, with a correlation coefficient of 0.9999. The proposed procedure was accurate and precise, allowing the detection of MIT at a concentration level of 0.24 mg L−1. It successfully demonstrated its suitability for the determination of methylisothiazolinone in household products without the need for any separation steps. The proposed method can serve as an alternative to the prevailing chromatographic determinations of MIT in real samples.

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Sustainability of surfactant-based electrochemical sensing and biosensing over conventional methods such as HPLC and GC

Rajkumar,

Karpagavinayagam,

Kirupagaran

et al. 2024

Surfactant Based Electrochemical Sensors and Biosensors

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Determination of methylisothiazolinone in waters. Comprehensive study about electrochemical behaviour on gold electrode and optimization of square-wave voltammetric methods

Cited by 5 publications

References 34 publications

Graphene Functionalized with Imidazole Derivatives as Nanotransducers for Electrochemically Detecting Isothiazolinone Biocides

Graphene Functionalized with Imidazole Derivatives as Nanotransducers for Electrochemically Detecting Isothiazolinone Biocides

Electrochemical Characterization and Voltammetric Determination of Methylisothiazolinone on a Boron-Doped Diamond Electrode

Sustainability of surfactant-based electrochemical sensing and biosensing over conventional methods such as HPLC and GC

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