Determination of methylamine, dimethylamine, and trimethylamine in air by high-performance liquid chromatography with derivatization using 9-fluorenylmethylchloroformate

Iqbal, Mohammad Asif; Szulejko, Jan E.; Kim, Ki‐Hyun

doi:10.1039/c4ay00740a

Cited by 38 publications

(7 citation statements)

References 42 publications

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“…Several works have been developed to improve the analytical techniques such as using sorptive media, solid phase microextraction (SPME), preconcentration by applying derivatization reagents, thermal desorption (TD) coupled with GC--time of flight mass spectrometry (TOF-MS) Iqbal et al, 2014;Kim et al, 2002;Kim et al, 2013), in order to enhance the precision, detector sensitivity for TMA analysis in environmental samples with very low concentrations. collected after 4 hours to be analyzed by GC/FID.…”

Section: Gas-phase Tma Standard Preparation Equilibrium Calibrationmentioning

confidence: 99%

Cleanup of trimethylamine (fishy odor) from contaminated air by various species of Sansevieria spp. and their leaf materials

Boraphech

Suksabye

Kulinfra

et al. 2016

International Journal of Phytoremediation

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Removal of trimethylamine (TMA) by 10 different living Sansevieria spp. and their dried leaf materials was studied. The results showed that living Sansevieria kirkii was the most effective plant while Sansevieria masoniana was the least effective in TMA removal. Two major pathways were involved in stomata opening and epicuticular wax on the leaf surface. In the presence of TMA, the stomata opening in Sansevieria spp. was induced, which enhanced TMA removal under light conditions. Dried leaf powders of Sansevieria spp. adsorbed TMA through their waxes. Therefore, both living and non-living Sansevieria spp. can be effectively used for removal of TMA.

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Section: Gas-phase Tma Standard Preparation Equilibrium Calibrationmentioning

confidence: 99%

Cleanup of trimethylamine (fishy odor) from contaminated air by various species of Sansevieria spp. and their leaf materials

Boraphech

Suksabye

Kulinfra

et al. 2016

International Journal of Phytoremediation

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“…14 An orthogonal strategy to reduce the potential activity of amines, as well as improve their detection sensitivity is by chemical derivatization of the analytes. 15,16 Coupling derivatization chemistry to chromatographic systems with sensitive MS detection can improve the quantification of amines to trace/ultra-trace levels. 17–19…”

Section: Introductionmentioning

confidence: 99%

A simple and universal headspace GC-FID method for accurate quantitation of volatile amines in pharmaceuticals

You,

Ho,

Rucker

et al. 2023

Anal. Methods

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“…To the best of our knowledge, there are no reports on the determination of N-nitrosamines using Fmoc-Cl. However, there are a few reports on the determination of DMA, which is a product of the denitrosation of NDMA [17][18][19][20]. The aim of our research is to develop a reproducible analytical method that would provide an appropriate LOQ, as required by the European Medicines Agency (EMA), and would not require expensive and sophisticated equipment, such as GC-MS and LC-MS. For this purpose, the most popular reagent for the derivatisation of N-nitrosamines, dansyl chloride and the first used for this purpose, Fmoc-Cl, were selected.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Method for the Semi-Quantitative Determination of N-Nitrosamines in Active Pharmaceutical Ingredient Enalapril Maleate by Means of Derivatisation and Detection by HPLC with Fluorimetric Detector

et al. 2021

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A novel HPLC method with fluorimetric detection was developed for the determination of potentially carcinogenic N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) in active pharmaceutical ingredient enalapril maleate. N-nitrosamines were subject to denitrosation followed by derivatisation with dansyl chloride or fluorenylmethoxycarbonyl chloride (Fmoc-Cl). Fmoc-Cl offers much better sensitivity and repeatability than dansyl chloride derivatisation. A satisfactory linearity was obtained for the method, with R2 = 0.9994 for NDMA and 0.9990 for NDEA, and a limit of quantification level of 0.038 μg/g for NDMA and 0.050 μg/g for NDEA. The precision decreased with the concentration to a maximum level of about 10%. The recoveries were in the range of 74.2 ± 4.2% to 101.6 ± 16.1% for NDMA and 90.6 ± 2.9% to 125.4 ± 7.4% for NDEA. Dansyl chloride was found to be an inappropriate derivatisation agent, mainly due to potential contamination with dimethylamine, leading to unrepeatable peaks in the blank solution. Since the method involves the derivatisation of amines liberated from the N-nitrosamines, it was necessary to remove the amines from the test sample. Several critical points in the standard/sample preparation have been mentioned, which affect the reproducibility of the method and are not covered in similar articles.

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Determination of methylamine, dimethylamine, and trimethylamine in air by high-performance liquid chromatography with derivatization using 9-fluorenylmethylchloroformate

Abstract: An FMOC-based derivatization approach was developed to analyze gaseous amines by HPLC/UV. An impinger-based headspace collection and amine-derivatization system is also described.

Cited by 38 publications

References 42 publications

Cleanup of trimethylamine (fishy odor) from contaminated air by various species of Sansevieria spp. and their leaf materials

Cleanup of trimethylamine (fishy odor) from contaminated air by various species of Sansevieria spp. and their leaf materials

A simple and universal headspace GC-FID method for accurate quantitation of volatile amines in pharmaceuticals

Development and Validation of a Method for the Semi-Quantitative Determination of N-Nitrosamines in Active Pharmaceutical Ingredient Enalapril Maleate by Means of Derivatisation and Detection by HPLC with Fluorimetric Detector

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