Determination of metastable zone width, induction period and primary nucleation kinetics for cooling crystallization of l -asparaginenohydrate

Lenka, Maheswata; Sarkar, Debasis

doi:10.1016/j.jcrysgro.2014.09.027

Cited by 75 publications

(45 citation statements)

References 14 publications

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“…There are several approaches for the estimation of nucleation kinetics from MSZW or induction times, including the stochastic probability distribution model approach [14][15][16][17][18][19][20][21][22][23] and the empirical power law model approach [11,[24][25][26][27][28][29][30][31][32][33]. Each approach builds on different assumptions.…”

Section: Introductionmentioning

confidence: 99%

Validation of Models Predicting Nucleation Rates from Induction Times and Metastable Zone Widths

Maosoongnern

Flood

2018

Chem Eng & Technol

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Three approaches for estimation of nucleation rates from induction time and metastable zone width (MSZW) were validated based on directly measured nucleation rates for paracetamol in ethanol. To quantitatively predict nucleation kinetics using Kubota's methods it is necessary to know the minimum detectable number concentration of nuclei. This was found by determination of light transmission of a series of diluted suspensions of newly nucleated crystals where the size had already been assessed by optical reflection measurement (ORM). The measured nucleation rates strongly depended on both temperature and supersaturation. The Nyvlt method predicted nucleation rates in this system reasonably well; however, it gave slightly low estimates for all temperatures. The methods of Kubota provided nucleation rates that were low by an order of magnitude.

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Section: Introductionmentioning

confidence: 99%

Validation of Models Predicting Nucleation Rates from Induction Times and Metastable Zone Widths

Maosoongnern

Flood

2018

Chem Eng & Technol

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“…This approach has been used to provide further understanding of the solute-solvent interactions 25 , as well as transition state 26 , solvation shell 4 and desolvation process 27 . The relation between induction time and MSZW in supersaturated solutions has been compared 28 , however the relation between MSZW, interfacial energy and pre-exponential factor has not been established [29][30] . The motivation for this study is therefore to address this gap and further understand nucleation thermodynamics and kinetics during MSZW experiments.…”

Section: Introductionmentioning

confidence: 99%

Relating induction time and metastable zone width

Yang

Florence

2017

CrystEngComm

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“…The cooling crystallization of L‐asparagine monohydrate was conducted using its aqueous solution saturated at 42°C . The solution is preheated to 50°C and kept at this temperature for some time.…”

Section: Resultsmentioning

confidence: 99%

In situ determination of metastable zone width by a simple optical probe

Jaiswal

Sarkar

2015

Crystal Research and Technology

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The metastable zone width (MSZW), which denotes the region between the solubility curve and the onset of nucleation, is an important control parameter for successful operation of a solution crystallization process as it defines an operating boundary for the crystallization process. The MSZW can be approximated as the gap between the loci of cloud points that correspond to onset of nucleation and clear points that closely represent solubility. This work presents the design and application of a simple optical probe consisting of a line laser source, a light‐dependent resistor, and a simple processing circuit for in situ determination of onset of nucleation of a crystallization process. Three different crystallization processes, namely, cooling crystallization of glycine, cooling crystallization of L‐asparagine monohydrate, and anti‐solvent crystallization of glycine, are investigated to assess the performance of the in situ probe. In all the cases, the cloud points and clear points are conveniently detected by sharp changes in output voltage of the probe with reasonable accuracy. The presented optical probe can be used as a simple and inexpensive alternative tool in the area of crystallization process monitoring.

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Determination of metastable zone width, induction period and primary nucleation kinetics for cooling crystallization of l -asparaginenohydrate

Cited by 75 publications

References 14 publications

Validation of Models Predicting Nucleation Rates from Induction Times and Metastable Zone Widths

Validation of Models Predicting Nucleation Rates from Induction Times and Metastable Zone Widths

Relating induction time and metastable zone width

In situ determination of metastable zone width by a simple optical probe

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