Determination of mercaptobenzimidazol and other thyreostat residues in thyroid tissue and meat using high-performance liquid chromatography–mass spectrometry

Wasch, Katia De; Brabander, H.F. Be; Impens, Sandra; Vandewiele, M.; Courtheyn, D.

doi:10.1016/s0021-9673(01)00563-5

Cited by 68 publications

(37 citation statements)

References 10 publications

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“…De Wasch et al [88] have used SPE followed by HPLC-ESI-MS n for the determination of mercaptobenzimidazol and other thyreostat residues in thyroid tissue and meat with a detection limit of 20 mg/kg. After SPE the analytes were derivatised with 7-chloro-4-nitrobenzo-2-furazan.…”

Section: Benzimidazolesmentioning

confidence: 99%

A critical evaluation of high performance liquid chromatography‐electrospray ionisation‐mass spectrometry and capillary electrophoresis‐ electrospray‐mass spectrometry for the detection and determination of small molecules of significance in clinical and forensic science

Smyth¹,

Brooks

2004

Electrophoresis

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A critical review of applications for the period 2000-2003, taken from the Web of Knowledge database, of the techniques high performance liquid chromatography-electrospray ionisation-mass spectrometry (HPLC-ESI-MS) and capillary electrophoresis-electrospray ionisation-mass spectrometry (CE-ESI-MS) to the detection and determination of small molecules of significance in clinical and forensic science is presented. The molecules of mass less than 500 Da are chosen according to selected structural classes in which they give ESI signals primarily as [M+H](+) ions although other ions such as [M-H](-), [M+Na](+) and [M+NH(4)](+) are also reported. The structural classes are drugs with amine-containing side chains, drugs with N-containing saturated ring structures, 1,4-benzodiazepines, carbohydrates, benzimidazoles, other heterocycles, sulphonylureas, anthracyclines, sulphonamides, penicillins, cephalosporins, tetracyclines, nitrocatechols, steroids, flavonoids, oxazaphosphorines, cannabinols, and miscellaneous molecules. Details are given on the fragmentations, where available, that these ionic species exhibit in-source and in ion-trap, triple quadrupole and time-of-flight mass spectrometers. The review then gives a critical evaluation of these recent HPLC-ESI-MS and CE-ESI-MS analytical methods for the detection and determination of small molecules of clinical and forensic significance. Analytical information on, for example, sample concentration techniques, HPLC and CE separation conditions, recoveries from biological media and limits of detection (LODs) are provided.

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Section: Benzimidazolesmentioning

confidence: 99%

A critical evaluation of high performance liquid chromatography‐electrospray ionisation‐mass spectrometry and capillary electrophoresis‐ electrospray‐mass spectrometry for the detection and determination of small molecules of significance in clinical and forensic science

Smyth¹,

Brooks

2004

Electrophoresis

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“…The extracts are then cleaned-up by liquid-liquid extraction (LLE) with diethyl (23) ether or dichloromethane (20) or combination of LLE with solid phase extraction (SPE), mainly with silica cartridges, but also with C18 columns (1,11,25). The use of gel permeation chromatography (GPC) as an alternative clean-up strategy was also described (2).…”

Section: Introductionmentioning

confidence: 99%

Determination of the Thyreostats in Animal Feeding Stuffs Using Liquid Chromatography-Tandem Mass Spectrometry

Woźniak

Witek

Matraszek-Żuchowska

et al. 2014

Bulletin of the Veterinary Institute in Pulawy

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A rapid liquid chromatography tandem mass spectrometry method was developed and validated to detect and confirm five thyreostatic drugs: tapazole, thiouracil, methylthiouracil, propylthiouracil, and phenylthiouracil in animal feeding stuff samples. Thyreostats were extracted from feed with methanol, and then degreasing of the extract with petroleum ether was performed, followed by the derivatisation of the compounds with 3-iodobenzylbromide in basic medium (pH 8.0). The derivatives were extracted with diethyl ether and analysed by gradient elution on a Poroshell 120-EC C18 column with triple quadrupole MS detection with turbo spray source in positive ionisation mode. The method was validated in accordance with the Commission Decision 2002/657/EC. For validation level of 10 μg kg -1 , the recovery ranged from 82% to 97.5% for all examined compounds. The repeatability and reproducibility did not exceed the limit of 20% for all analytes. The linearity was good for all thyreostats in the whole range of tested concentrations, as proved by the correlation coefficients greater than 0.99. The decision limits (CC) ranged from 1.63 μg kg -1 to 3.95 μg kg -1 , whereas the detection capabilities (CC) ranged from 2.74 μg kg -1 to 6.73 μg kg -1 . The developed analysis is sensitive and robust, and therefore useful for quantification and confirmation of thyreostats in residue control programme.

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“…Various methods have already been reported for detection and determination of MMI in biological samples. These techniques were high-performance liquid chromatographymass spectrometry (HPLC-MS) [19], liquid chromatography with UV detection [20], reverse-phase HPLC [21] and gas chromatography-mass spectrometry (GC-MS) [22]. Electrochemical methods using glassy carbon modified with thin film of polynuclear indium(III) hexacyanoferrate [23] and square wave voltammetry using a Pt microdisk [24] have been applied for the determination of MMI with micromolar detection limits.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Methimazole Using a Carbon Paste Electrode Modified with a Schiff Base Complex of Cobalt

Shahrokhian

Ghalkhani

2008

Electroanalysis

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The electrochemical behavior of methimazole, as an antithyroid agent, is investigated on the surface of a carbon-paste electrode modified with a newly synthesized Schiff base complex of cobalt. The prepared modified electrode showed an efficient catalytic role in the electrochemical oxidation of methimazole, leading to remarkable decrease in oxidation overpotential and enhancement of the kinetics of the electrode reaction. The mechanism of the electrocatalytic process on the surface of the modified electrode is analyzed by obtaining the cyclic voltammograms in various potential sweep rates and pHs of the buffer solutions. The differential pulse voltammetry is applied as a very sensitive analytical method for the determination of sub-micromolar amounts of methimazole. A linear dynamic range of 1 Â 10 À6 to 1 Â 10 À4 M with a detection limit of 5 Â 10 À7 M is resulted for methimazole. The modified electrode is successfully applied for the accurate determination of methimazole in pharmaceutical and clinical preparations. The linear range in calibration curves remains constant in addition to tablet preparations of methimazole and also in spiking to the synthetic human serum samples. In comparison to calibration curves in background buffer solution, the slope of the curves showed a variation less than 3% in determinations in background solutions of tablet and human synthetic serum samples. These results showed high efficiency of the Voltammetric procedure for accurate determination of methimazole in drug and clinical preparations. The modified electrode can be prepared very easy and renewed in its surface by simple polishing. The reproducibility of the electrode response, based on ten measurements during two month, was 3.2% for the slope of the calibration curve.

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Determination of mercaptobenzimidazol and other thyreostat residues in thyroid tissue and meat using high-performance liquid chromatography–mass spectrometry

Cited by 68 publications

References 10 publications

A critical evaluation of high performance liquid chromatography‐electrospray ionisation‐mass spectrometry and capillary electrophoresis‐ electrospray‐mass spectrometry for the detection and determination of small molecules of significance in clinical and forensic science

A critical evaluation of high performance liquid chromatography‐electrospray ionisation‐mass spectrometry and capillary electrophoresis‐ electrospray‐mass spectrometry for the detection and determination of small molecules of significance in clinical and forensic science

Determination of the Thyreostats in Animal Feeding Stuffs Using Liquid Chromatography-Tandem Mass Spectrometry

Voltammetric Determination of Methimazole Using a Carbon Paste Electrode Modified with a Schiff Base Complex of Cobalt

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