Determination of meprobamate in tablets by NMR

Improved solid-state NMR quantifications of active principles in pharmaceutical formulations

“…The use of an internal standard reduces the effects of instrumental instabilities and allows direct quantifications to be achieved [15][16][17]. The most significant drawbacks are the difficulty of preparing homogeneous mixtures of sample and standard, an especially critical step in the solid state, and the reduction in sensitivity caused by sample dilution.…”

“…While a few distinct analytical protocols have indeed been proposed for the dosage of Meprobamate, based either on chromatographic [19] or spectroscopic techniques [15], a trusted method has not been singled out. The sole official suggestion is to be found in the United States Pharmacopeia monograph which recommends the use of reversed phase liquid chromatography at 200 nm to assay Meprobamate in tablets [20].…”

GLC Assay of Meprobamate and Related Carbarnates

“…Methods based on the acid-catalyzed condensation with an aldehyde (4, 5 ) and the ability of hypochlorite to Nchlorinate unsubstituted carbamate nitrogen ( 6 ) have been reported. Spectral methods based on IR, near IR, and NMR absorption also have been reported (7)(8)(9).…”

Analysis of Cacodylate Injections by NMR Spectroscopy

“…A number of reviews and articles have been wholly (3)(4)(5) or partially (6-19) devoted to quantitative analysis by NMR. Besides the quantitation of the cacodylate compound discussed in this paper, other pharmaceuticals in various dosage forms that have been quantitated previously are aspirin-phenacetincaffeine (20,21), aspirin (22), chlorophenesin carbamate (23), barbiturates (24), methylxanthines (25), mestranol (26), meprobamate (27), dimethyl sulfoxide (28), chloral hydrate (29), pentylenetetrazol (30), and aminophylline (3 1). With the cacodylate, the proton magnetic resonance exhibited by both of the methyl groups bonded to the arsenic is measured quantitatively by comparison to an internal standard.…”