Determination of Mefenamic Acid in Aqueous Solutions Using Reverse - Continuous Flow Injection Analysis

Abstract

This research aims to use a novel algorithm to determine the concentration of Mefenamic acid. The MA concentration in aqueous solutions was determined using this technology, and the results obtained using more conventional methods were compared to those obtained using more traditional methods. A signal detector and a specialized software spectrometer then receive the data. The maximum wavelength of the product is determined using a spectroscopic scan, a calibration curve is constructed, and measurements are made to estimate the drug's absolute concentrations in aqueous solutions. This treatment is popular because it is simple, rapid, precise, inexpensive, and adaptable.

Método de inyección de flujo sensible a base de neocuproina para la determinación de ácido mefenámico en soluciones acuosas y formulaciones farmacéuticas

“…Because of its selectivity for copper(I) and potent visual absorbance of the Cu(DMP) 2+ adduct, 2,9-dimethyl-1,10-phenanthroline (NC) is typically the reagent chosen for the colorimetric measurement of copper(I) (14) Water-insoluble mefenamic acid is somewhat soluble in (chloroform) and (ethers), faintly soluble in ethanol (4.6 mg/mL) and water (1:9), and more soluble in dimethylformamidee (38.5 mg/mL) (4) Mefenamic acid reduces inflammation and pain by inhibiting COX and prostaglandin synthesis since it provides cerebral and peripheral analgesia. Its nonselective COX inhibitors inhibit both COX-1 and COX-2 enzymes (5) Mefenamic Acid (MFA) operates in the same way as other nonsteroidal anti-inflammatory medicines by which blocking the enzymatic prostaglandin synthase (6) There are several known and reported analytical methods for measuring MEF acid in biological and pharmacological products (7) Spectrophotometry (8) Gas Chromatography (9) Extraction method of Micro-electrodriven Membranes in 2 Phases (10) capillary electrophoresis with two channels (11) RP-HPLC (12) Fluorometric method (13) Hyphenated Tech-niques (14) Electrospray Ionization Mass Spectrometry (15) Turbidity Measurement (16) flow injection method (17) MEF is determined by different flow injection technique, it has been estimated in pharmaceuticals by flow-injection (18) and estimation of Mefenamic Acid in Aqueous Solutions Using Reverse -Continuous Flow Injection Analysis (6) determination of MEF in pharmaceuticals formulation by flow-injection Fluorometry (21). However, in recent years there has been a growing interest in the use of Neocuproine (2,9-dimethyl-1,10-phenanthroline) as a complexing agent in analytical chemistry.…”