Determination of mechanical properties of hydroxyapatite doped with magnesium

Suciu, Oana; Bereteu, Liviu; Drăgănescu, Gheorghe

doi:10.1063/1.4832807

Cited by 7 publications

(7 citation statements)

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“…Indeed, Mg was only found within K. editha's shells, whereas K. gainesi had a larger amount of Al. In particular, Mg ions in trace amounts are usually responsible for increased Young's modulus [44,45]. As expected from the microscopic observations, the outer layer of K. gainesi's shells presented a high concentration of carbon with low mineral content, confirming the presence of a predominantly organic layer on the outer surface.…”

Section: Hierarchical Microstructure Of the Shellssupporting

confidence: 71%

Structure–behaviour correlations between two genetically closely related snail species

Ferrand

Morii

2020

R. Soc. open sci.

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Species, through their structure and composition, have evolved to respond to environmental constraints. Predator-prey interactions are among environmental pressures that can lead to speciation, but it remains unclear how this pressure can be related to the material structure and performance. Recently, two land snails, Karaftohelix editha and Karaftohelix gainesi, were found to exhibit divergent phenotypes and responses to predation despite sharing the same habitat and most of their genome. Indeed, under attack from a beetle, K. editha snails retract into their shell whereas K. gainesi snails swing their shell. In this paper, we looked at the microstructure, composition, morphology and mechanics of the shells of those two species and discuss potential relationships between material structure and the snail defence behaviour. The results of this study provide additional arguments for the role of predator-prey interactions on speciation, as well as an unusual approach for the design of biomimetic structures adapted to a particular function.

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Section: Hierarchical Microstructure Of the Shellssupporting

confidence: 71%

Structure–behaviour correlations between two genetically closely related snail species

Ferrand

Morii

2020

R. Soc. open sci.

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“…More than two million bone grafting procedures are performed annually at a global scale. Usually, bone tissue replacements are synthesized from bioactive materials that possess similarities with the natural human bone [1,2]. The materials generally used as bone substitutes are the biocompatible ceramics that have a mechanical strength similar to that of human bone.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, studies have emphasized that Mg addition exhibited an inhibitory effect on HAp nucleation, its crystal growth, and also that Mg in high concentration causes a significant reduction in crystallinity coupled with an increase of its dissolution [37,38,39,40,41]. The complex investigation study of physico-chemical properties of hydroxyapatite doped with magnesium in solution [2,3,9,14,17] are rather limited.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

et al. 2019

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Obtaining nanoscale materials has allowed for the miniaturization of components, which has led to the possibility of achieving more efficient devices with faster functions and much lower costs. While hydroxyapatite [HAp, Ca10(PO4)6(OH)2] is considered the most widely used material for medical applications in orthopedics, dentistry, and general surgery, the magnesium (Mg) is viewed as a promising biodegradable and biocompatible implant material. Furthermore, Mg is regarded as a strong candidate for developing medical implants due to its biocompatibility and antimicrobial properties against gram-positive and gram-negative bacteria. For this study, magnesium-doped hydroxyapatite (Ca10−xMgx (PO4)6 (OH)2, xMg = 0.1), 10MgHAp, suspensions were successfully obtained by an adapted and simple chemical co-precipitation method. The information regarding the stability of the nanosized 10MgHAp particles suspension obtained by ζ-potential analysis were confirmed for the first time by a non-destructive ultrasound-based technique. Structural and morphological studies of synthesized 10MgHAp were conducted by X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy in attenuated total reflectance (ATR) mode and scanning electron microscopy (SEM). The XRD analysis of the 10MgHAp samples confirmed that a single crystalline phase associated to HAp with an average grain size about 93.3 nm was obtained. The FTIR-ATR spectra revealed that the 10MgHAp sample presented broader IR bands with less visible peaks when compared to a well-crystallized pure HAp. The SEM results evidenced uniform MgHAp nanoparticles with spherical shape. The antimicrobial activity of the 10MgHAp suspension against gram-positive strains (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212), gram-negative strains (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), as well as a fungal strain (Candida albicans ATCC 90029) were evaluated.

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“…It has been successfully used to predict malignancy and cardiovascular outcomes [7][8][9]. More recently, it has been proposed as an independent factor to predict hip and knee radiographic severity, as well as modulate the postoperative period after arthroplasty [10][11][12][13][14]. However, none of these studies examined the association between NLR and commonly used patient reported outcomes (PROs) for knee OA.…”

Section: Introductionmentioning

confidence: 99%

Association of Neutrophil to Lymphocyte Ratio with Patient Reported Outcomes in Knee Osteoarthritis

et al. 2020

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Background: Determining the association of neutrophil to lymphocyte ratio (NLR) and clinical disease severity in patients with mild and advanced stage knee osteoarthritis (OA).Method: We analyzed clinical scores and routine hematology panels of 111 subjects with symptomatic knee degeneration: mild OA (66) who underwent knee arthroscopy and advanced OA (45) who had total replacement. Results: Compared to the advanced OA group, the mild OA group was younger (54/67), had fewer females (1.75/5.43), and better scores: Euroqol EQ5D Index (0.50/0.25), VAS (visual analog scale) (65/44); International knee documentation committee subjective knee evaluation form—IKDC (31.6/20.24); Knee disability and osteoarthritis outcome score for joint replacement—KOOSJR (15.5/18.3); and better Kellgren–Lawrence stage (1.3/3.8). Patients with advanced disease had higher NLRs compared to mild OA group and controls: 2.82 versus 1.99 (p = 0.004) and 1.98 (p = 0.002). In the multiple regression model, NLR was only influenced by age (p < 0.001). In the subgroup analysis, for the early OA cases, NLR was significantly dependent to VAS (p = 0.006), IKDC (p = 0.001) and KOOSJR (p < 0.001). Conclusion: NLR was not associated with symptomatic knee OA, as determined by commonly used patient reported outcomes. However, for patients with mild degenerative modifications, EQ5D, VAS, and IKDC were independent predictors of NLR.

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Determination of mechanical properties of hydroxyapatite doped with magnesium

Cited by 7 publications

References 0 publications

Structure–behaviour correlations between two genetically closely related snail species

Structure–behaviour correlations between two genetically closely related snail species

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

Association of Neutrophil to Lymphocyte Ratio with Patient Reported Outcomes in Knee Osteoarthritis

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