Determination of markers of coagulation activation and reactive fibrinolysis in patients with mechanical heart valve prosthesis at different intensities of oral anticoagulation

Wersch, J. W. J. Van; Mourik-Alderliesten, C. H. van; Coremans, A.

doi:10.1097/00001721-199204000-00007

Cited by 9 publications

(5 citation statements)

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“…A similar result was obtained in a study assessing the coagulation markers in patients with prosthetic heart valves at different intensities of oral anticoagulation, although the measured levels of Dd were higher than those in our study. 17 Our results support previous clinical studies which suggested that the rate of thromboembolic complications in patients with prosthetic valves is not reduced further by more aggressive anticoagulant therapy. 6 -7 However, long-term clinical trials are required to assess the optimum degree of anticoagulation.…”

Section: Discussionsupporting

confidence: 91%

Coagulation activity and emboli counts in patients with prosthetic cardiac valves.

Georgiadis

Mallinson

Grosset

et al. 1994

Stroke

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Background and Purpose The underlying embolic material detected by transcranial Doppler ultrasound in patients with prosthetic heart valves remains unknown. We undertook this study to evaluate the relation between the number of Doppler emboli signals and the activity of the coagulation system.Methods Patients with various types of prosthetic valves (n=120) and patients in atrial fibrillation (n=20) were monitored for 30 minutes using transcranial Doppler with a 2-MHz probe. The plasma concentrations of cross-linked D-dimer, antithrombin-III, and thrombin-antithrombin III complex were measured.Results No correlation between the levels of any of the hematologic parameters and the number of emboli was demonstrated in the studied groups. The D-dimer levels were significantly higher in patients with mechanical prosthetic valves with an international normalized ratio under 2.0 com-

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Section: Discussionsupporting

confidence: 91%

Coagulation activity and emboli counts in patients with prosthetic cardiac valves.

Georgiadis

Mallinson

Grosset

et al. 1994

Stroke

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“…13,25 Moreover, as expected, activation of the coagulation cascade via generation of thrombin was reduced in patients on warfarin therapy. 8,[26][27][28]…”

Section: Discussionmentioning

confidence: 99%

Chronic Threshold Testing of Implantable Cardioverter Defibrillators Does Not Increase Coagulation Activity or Platelet Activation

Smolich

Yates

Malan

et al. 2002

Pacing Clinical Electrophis

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It is unknown if the brief periods of circulatory statis occurring with induction of VF during DFT testing in patients with an ICD activate blood coagulation processes. To address this question, coagulation activity and platelet activation were measured in peripheral venous blood samples obtained from 12 patients undergoing DFT testing under general anesthesia, 3 (n = 11) or 6 months (n = 1) after ICD implantation for recurrent ventricular arrhythmias. Five patients were anticoagulated with warfarin and two to six episodes of VF (median five) were induced per patient. Blood samples were drawn at baseline, after each DFT test and on the following morning. Coagulation activity was assessed by measuring prothrombin fragment 1 + 2 (F1 + 2) (a marker of thrombin generation), soluble fibrin (a marker of fibrin production), and D-dimer (a breakdown product of cross-linked fibrin). Platelet activation was evaluated by measuring the expression P-selectin on the platelet surface using flow cytometry. No significant changes in F1 + 2, soluble fibrin, D-dimer, or P-selectin expression occurred during DFT testing, or between baseline and morning after samples. Moreover, results were unaffected by warfarin. These findings suggest that chronic threshold testing of implantable cardioverter defibrillators is not associated with activation of blood coagulation processes.

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“…Problems of effectively monitoring OAs can be addressed through anticoagulation clinics for children 1,63 and through the use of whole-blood monitors in the clinic and at home. 320…”

Section: Discussionmentioning

confidence: 99%

Antithrombotic Therapy in Children

Michelson¹,

Bovill²,

Andrew³

1995

Chest

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Determination of markers of coagulation activation and reactive fibrinolysis in patients with mechanical heart valve prosthesis at different intensities of oral anticoagulation

Cited by 9 publications

References 0 publications

Coagulation activity and emboli counts in patients with prosthetic cardiac valves.

Coagulation activity and emboli counts in patients with prosthetic cardiac valves.

Chronic Threshold Testing of Implantable Cardioverter Defibrillators Does Not Increase Coagulation Activity or Platelet Activation

Antithrombotic Therapy in Children

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