Determination of manganese concentrations in the spinal cords from amyotrophic lateral sclerosis patients by inductively coupled plasma emission spectroscopy

Kihira, Tameko; Mukoyama, Masakuni; Ando, Kazuo; Yase, Yoshiro; Yasui, Masayuki

doi:10.1016/0022-510x(90)90266-p

Cited by 23 publications

(13 citation statements)

References 10 publications

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“…Some studies in other locations found increased Mn levels in brain, spinal cord, and muscle from ALS patients (Kurlander and Patten, 1979; Mitchell et al, 1991; Miyata et al, 1983) while others did not (Kihira et al, 1990; Pierce-Ruhland and Patten, 1980). Most of these studies were small, however, and the observed changes in Mn levels may reflect tissue degeneration.…”

Section: Discussionmentioning

confidence: 97%

Blood levels of trace metals and amyotrophic lateral sclerosis

et al. 2016

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Some trace metals may increase risk of amyotrophic lateral sclerosis (ALS), whereas others may be beneficial. Our goal was to examine associations of ALS with blood levels of selenium (Se), zinc (Zn), copper (Cu), and manganese (Mn). We conducted a case-control study of 163 neurologist confirmed patients from the National Registry of Veterans with ALS and 229 frequency-matched veteran controls. We measured metal levels in blood using inductively coupled plasma mass spectrometry and estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between ALS and a doubling of metal levels using unconditional logistic regression, adjusting for age, gender, and race/ethnicity. ALS was inversely associated with both Se (OR=0.4, 95% CI: 0.2–0.8) and Zn (OR=0.4, 95% CI: 0.2–0.8). Inverse associations with Se were stronger in patients with bulbar compared to spinal onset, worse function, longer diagnostic delay, and longer collection delay; inverse associations with Zn were stronger for those with worse function and longer collection delay. In contrast, ALS was positively associated with Cu (OR=3.4, 95% CI: 1.5–7.9). For Mn, no linear trend was evident (OR=0.9, 95% CI: 0.6–1.3, Ptrend=0.51). Associations of Se, Zn, Cu, and Mn with ALS were independent of one another. Adjustment for lead levels attenuated the positive association of ALS with Cu but did not change associations with Se, Zn, or Mn. In conclusion, Se and Zn were inversely associated with ALS, particularly among those with worse function, suggesting that supplementation with these metals may benefit such patients, while Cu was positively associated with ALS. Deficiencies of Se and Zn and excess Cu may have a role in ALS etiology.

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Section: Discussionmentioning

confidence: 97%

Blood levels of trace metals and amyotrophic lateral sclerosis

et al. 2016

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“…ALS arising in a patient affected by liver cirrhosis, a condition known to imply Mn overload due to impaired biliary excretion of the metal [174], has also been observed [175]. Mn overload has been reported in pathological and analytical studies of Guamanian and sporadic ALS cases [176, 177, 178, 179, 180]; the last two studies also showed an increase in MnSOD levels in motor neurons of affected subjects. Indeed, environmental data from the Western Pacific endemic foci of ALS, including the Kii peninsula in Japan, support a role for Mn in its prevalence in these areas [181, 182] and contribute to what is generally called “the mineral hypothesis” of the ALS/Parkinson’s Dementia Complex (ALS/PDC).…”

Section: Mn and Amyotrophic Lateral Sclerosis (Als)mentioning

confidence: 99%

Role of manganese in neurodegenerative diseases

Bowman

Kwakye

Hernández

et al. 2011

Journal of Trace Elements in Medicine and Biology

340

230

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“…Nagata et al [61] showed that the Mn concentrations in blood cells from ALS patients were significantly lower than from controls (non-ALS subjects). On the other hand, Kihira et al [62] with the use of the Inductively Coupled Plasma (ICP) spectroscopy, discovered that the mean content of Mn in the spinal cord was similar for ALS (0.39 microgram/g wet weight in the anterior horn, 0.37 in the lateral fasciculus, 0.39 in the posterior horn and 0.28 in the posterior fasciculus) and control subjects but the distribution of this element differed. In case of ALS, the content of Mn was higher in the anterior horn and lateral fascicules than in the posterior horn.…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological studies of endemic foci of ALS at the Kii Penisula and Guam have shown chronically low concentrations of Ca, Mg and high concentrations of Al and Mn in garden soil and drinking water. It was hypothesized that chronically low concentrations of Ca/Mg in food enhance the absorption of Al from the gastrointestinal tract and induce deposition of Al with Ca in the central nervous system, causing neuronal vulnerability and/or degeneration in Kii-ALS [62].…”

Section: Discussionmentioning

confidence: 99%

Implementation of X-ray Fluorescence Microscopy for Investigation of Elemental Abnormalities in Amyotrophic Lateral Sclerosis

Tomik

Chwiej

Szczerbowska-Boruchowska

et al. 2006

Neurochem Res

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The abnormalities of metallochemical reactions may contribute to the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). In the present work, an investigation of the elemental composition of the gray matter, nerve cells and white matter from spinal cord tissues representing three ALS cases and five non-ALS controls was performed. This was done with the use of the synchrotron microbeam X-ray fluorescence technique (micro-SRXRF). The following elements were detected in the tissue sections: P, S, Cl, K, Ca, Fe, Cu, Zn and Br. A higher accumulation of Cl, K, Ca, Zn and Br was observed in the nerve cell bodies than in the surrounding tissue. Contrary to all other elements, Zn accumulation was lower in the white matter areas than in the gray matter ones. The results of quantitative analysis showed that there were no general abnormalities in the elemental accumulation between the ALS and the control group. However, for individual ALS cases such abnormalities were observed for the nerve cells. We also demonstrated differences in the elemental accumulation between the analyzed ALS cases.

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Determination of manganese concentrations in the spinal cords from amyotrophic lateral sclerosis patients by inductively coupled plasma emission spectroscopy

Cited by 23 publications

References 10 publications

Blood levels of trace metals and amyotrophic lateral sclerosis

Blood levels of trace metals and amyotrophic lateral sclerosis

Role of manganese in neurodegenerative diseases

Implementation of X-ray Fluorescence Microscopy for Investigation of Elemental Abnormalities in Amyotrophic Lateral Sclerosis

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