Determination of Lipid Profiles and Use of Statins in Patients With Ischemic Stroke or Transient Ischemic Attack

Abstract

Background and Purpose-Statins reduce the risk of myocardial infarction and stroke in patients with vascular disease.Inappropriate serum lipid determination and underuse of statins have been documented in patients with coronary artery disease. Evaluation of hyperlipidemia and treatment with statins in patients with recent ischemic cerebrovascular eventshave not yet been investigated. Methods-We determined the frequency of total cholesterol (TC) and low-density lipoprotein cholesterol measurements and the use of statins in a multicenter prospective cohort study of 1743 patients with acute ischemic stroke or transient ischemic attack (TIA). Using multivariate logistic regression analysis, we determined the influence of several clinical variables on lipid measurements and the prescription of statins at hospital discharge. Results-TC was measured in 90% and low-density lipoprotein cholesterol was measured in 48% of the patients.Differences between the centers accounted for most of the observed variability in a multivariate model. Statin prescription also varied widely between the centers. The prescription of a statin at discharge was most strongly associated with statin intake before the event and with increasing TC levels; elderly patients received statins less often. Coronary artery disease, peripheral artery disease, and other manifestations of atherosclerosis were not independently associated with the use of statins; 68% of the patients with manifest atherosclerosis and TC levels Ͼ200 mg/dL were discharged without a statin. Conclusions-The

Frequency and Determinants of Lipid Testing in Ischemic Stroke and Transient Ischemic Attack

“…9 The multi-center Vienna Stroke Registry found that although 90% of hospitalized ischemic stroke and TIA survivors enrolled in 1998 to 2001 had measurement of total cholesterol, only 48% had measurement of LDL. 17 The somewhat higher initial frequency of LDL measurement in the GWTG-Stroke program in 2003 may reflect the voluntary enrollment of hospitals interested in participating in a quality improvement program. Calendar time and duration of participation in GWTGStroke were both independently associated with increased odds of LDL measurement (Table 2).…”

Effect of high fructose administration on histopathology of kidney, heart and aorta of rats

“…Glutamic oxaloacetic transaminase (GOT); glutamic pyruvic transaminase (GPT), lactate dehydrogenase (LDH) activity were measured by a kinetic method using commercial kits (Egyptian company for biotechnology) (Young, 1990). Serum lipid profile including cholesterol, triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) was estimated using commercial kits Vitro Scient Diagnostic Company (Egypt) (Lalouschek et al, 2003). Malonyldialdehyde (MDA) was determined spectrophotometrically according to (Ohkawa et al, 1979).…”

Risk of pneumonia associated with zero‐degree head positioning in acute ischemic stroke patients treated with intravenous tissue plasminogen activator

“…Stroke severity with a NIHSS score ≥10 points has been attributed to pneumonia risk, along with age ≥65 years, dysarthria, aphasia, a mRS ≥4 points, nonlacunar‐basal ganglia infarction, presence of existing infection, intubation, BiPAP use, failed water swallow test (dysphagia), and comorbid conditions which include chronic obstructive pulmonary disease and coronary artery disease (Dziewas et al. 2003; Hilker et al. 2003; Finlayson et al.…”