Determination of Lethal Dose (LD50) of Venom of four Different Poisonous Snakes found in Pakistan

Lethal dose (LD50) of the big four snakes-a mini review

“…7 According to Australian online biodata of snake venom LD 50 of Echiscarinatus multisquamatus is 3.26 μg/g. 8 In case of Russell viper (Viperarusselii) the LD 50 was 0.3321 μg/g estimated by Parveen et al 5 and 0.3 μg/g as calculated by Meier and Theakston (1986).…”

“…Australian Venom and Toxin database depicts the LD 50 value 0.169μg/g for Krait. 8 The LD 50 of cobra (Najanaja) estimated by Perveen et al 5 was 0.2828 μg/g. Riaz & Zaman 11 estimated LD 50 of cobra about 1.2μg/g.…”

“…Forkrait (Bungaruscaeruleus) LD 50 calculated by Perveen et al 5 is 0.2828 μg/g for intravenous route. Engelmann and Obst et al 9 obtained LD 50 value is 0.169μg/g and Mirajkar & More et al 10 reported LD 50 of 0.16 μg/g.…”

“…This study presents the overview of the LD 50 as estimated by various researchers on mice. The LD 50 of Echiscarinatus (Saw-scaled viper) estimated by Parveen et al 5 was 0.5655μg/g and by 6 was 22 μg/mouse of mice through intravenous route. LD 50 of Echiscarinatus multisquamatus which is found in Iran was calculated as 11.1 μg/mouse.…”

“…The toxicity and lethality of the snake venom varies from species to species and even within the species depending upon geographical location, route of venom injection, age, size, locality, health, body temperature and even mood of the snake. Parveen et al 5 determined the LD 50 of big four snakes as LD 50 of cobra (NajaNaja) about 6 to 7 μg/dose, Saw Scaled Viper (Echiscarinatus) 11 to 12 μg/dose, Russelviper (Viperarusselli) 5 to 6 μg/dose and Krait (Bungarescaeruleus) 4 to 5 μg/dose when injected intravenously ( Figure 1). Different researcher conducted studies to investigate the LD 50 of big four snakes at various institutes.…”