Determination of lapachol in the presence of other naphthoquinones using 3MPA-CdTe quantum dots fluorescent probe

Aucélio, Ricardo Q.; Peréz-Cordovés, Ana I.; Lima, Juliano L.X.; Ferreira, Aurélio B. B.; Guas, Ana Margarita Esteva; Silva, Andrea R. da

doi:10.1016/j.saa.2012.04.020

Cited by 10 publications

(6 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lapachol, α-lapachone and β-lapachone are the most highly concentrated compounds of the naturally occurring naphthoquinones in Tabebuia spp (Cavalcante et al, 2008). Lapachol is an easily extracted prenylated naphthoquinone and represents about 3 to 7% of the total chemical constituents of the plant, depending on the species (Aucélio et al, 2013;. This substance has been widely studied since the discovery of its antiparasitic potential by the researcher Wendel in 1946 (Silva et al, 2012), and is an important representative of the group of quinones in tabebuias, forminga raw material in the syntheses of other compounds with different biological dynamics (Silva et al, 2003).…”

Section: Naphthoquinones and The Tabebuia Genusmentioning

confidence: 99%

Anti-inflammatory and cicatrizing properties of the Tabebuia genus: A review

Brito

Pereira

Silva

et al. 2021

RSD

View full text Add to dashboard Cite

The Tabebuia genus is one of the largest genera of the Bignoniaceae family, comprising more than 100 species. One of its main representatives is the ipê tree, which is popularly known for their ornamental and logging potential. However, parts of the tree, such as the stem, leaves and flowers, are used in traditional medicine for anti-bacterial, anti-inflammatory (rhinitis, sinusitis, tonsillitis and pharyngitis), anti-ulcerogenic, antiviral, antineoplastic, antimalarial and immunomodulatory purposes. The objective of the present study was to collate articles on the cicatrizing and therapeutic properties of species belonging to the Tabebuia spp genus.

show abstract

Section: Naphthoquinones and The Tabebuia Genusmentioning

confidence: 99%

Anti-inflammatory and cicatrizing properties of the Tabebuia genus: A review

Brito

Pereira

Silva

et al. 2021

RSD

View full text Add to dashboard Cite

show abstract

“…Quinonoid compounds, including 1,4‐naphthoquinones, are ubiquitous in nature and many bioactive naphthoquinones are found in South American plants, such as lapachol, which is isolated from the Bignoniaceae family (Aucélio et al . ).…”

Section: Introductionmentioning

confidence: 97%

“…They are classified according to the parent aromatic hydrocarbon system such as benzoquinone, anthraquinones and naphthoquinones. Quinonoid compounds, including 1,4-naphthoqui-nones, are ubiquitous in nature and many bioactive naphthoquinones are found in South American plants, such as lapachol, which is isolated from the Bignoniaceae family (Auc elio et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of lapachol metabolites produced by probiotics

Silva

Carvalho

Parshikov

et al. 2014

Lett Appl Microbiol

View full text Add to dashboard Cite

Significance and Impact of the Study: Probiotics have been used in dairy products to promote human health and have the ability to metabolize drugs and other xenobiotics. Naphthoquinones, such as lapachol, are considered privileged scaffolds due to their high propensity to interact with biological targets. The present study is the first to demonstrate that probiotics are capable of converting lapachol into the most effective cytotoxic compound against a breast cancer cell line. The developed approach highlights the importance of probiotics to assess the effects of bacterial metabolism on drug performance and toxicity. AbstractProbiotics are currently added to a variety of functional foods to provide health benefits to the host and are commonly used by patients with gastrointestinal complaints or diseases. The therapeutic effects of lapachol continue to inspire studies to obtain derivatives with improved bioactivity and lower unwanted effects. Therefore, the general goal of this study was to show that probiotics are able to convert lapachol and are important to assess the effects of bacterial metabolism on drug performance and toxicity. The microbial transformations of lapachol were carried out by Bifidobacterium sp. and Lactobacillus acidophilus and different metabolites were produced in mixed and isolated cultures. The cytotoxic activities against breast cancer and normal fibroblast cell lines of the isolated metabolites (4a-hydroxy-2,2-dimethyl-5-oxo-2,3,4,4a,5,9b-hexahydroindeno [1,2-b]pyran-9b-carboxilic acid, a new metabolite produced by mixed culture and dehydro-a-lapachone produced by isolated cultures) were assessed and compared with those of lapachol. The new metabolite displayed a lower activity against a breast cancer cell line (IC 50 = 532Á7 lmol l À1 ) than lapacholdisplayed a higher activity than lapachol. The present study is the first to demonstrate that probiotics are capable of converting lapachol into the most effective cytotoxic compound against a breast cancer cell line.

show abstract

“…Muitas naftoquinonas bioativas, como o lapachol, são encontradas em plantas típicas da América do Sul, principalmente em árvores da família Bignoniaceae, podendo representar cerca de 3-7% da composição em massa do caule dessas espécies (CASTELLANOS et al, 2009;AUCÉLIO et al, 2013). As atividades biológicas do lapachol vêm sendo estudadas desde o início de 1960, incluindo atividades contra…”

Section: íNdice Deunclassified

Estudos sobre o metabolismo microbiano de naftoquinonas e avaliação da citotoxicidade dos metabólitos obtidos

Silva¹

View full text Add to dashboard Cite

Determination of lapachol in the presence of other naphthoquinones using 3MPA-CdTe quantum dots fluorescent probe

Cited by 10 publications

References 36 publications

Anti-inflammatory and cicatrizing properties of the Tabebuia genus: A review

Anti-inflammatory and cicatrizing properties of the Tabebuia genus: A review

Cytotoxicity of lapachol metabolites produced by probiotics

Estudos sobre o metabolismo microbiano de naftoquinonas e avaliação da citotoxicidade dos metabólitos obtidos

Contact Info

Product

Resources

About