Determination of kFLC and K Index in cerebrospinal fluid: A valid alternative to assessintrathecal immunoglobulin synthesis

K Index in cerebrospinal fluid: a valid tool in multiple sclerosis diagnosis

“…These are recent data obtained by a new diagnosis of two patients previously diagnosed as leukoencephalitis and revaluated as MS. The two patients are women and have a kFLC Index of 26.6 and 154 respectively, values much higher than the previously published cut-off > 12 [15].…”

“…Our previous data [15], has been further improved thanks to a reevaluation of two patients subsequently confirmed with a MS diagnosis. The current study suggest the implementation of kFLC Index determination as a screening method in CSF analysis before further investigation for a possible intrathecal immune response, especially where MS or CIS is suspected.…”

“…Patient characteristics and patient groups are shown in Table 1 All patients from group 1 and group 2, have a kappafree light chain concentrations in CSF below the cutoff of 0.4 mg/L [15]. All data of the kFLC concentrations in CSF of the group 3 are above the cut off value and shows a statistically significant difference respect the group 1 and 2, for details see Figure 1.…”

“…We compared it with traditional tests to detect intrathecal immunoglobulin synthesis and investigated the usefulness of this method for clinical application. Recently our laboratory investigated CSF/serum pairs from patients: the results obtained are compared with the standard oligoclonal band assessment that was taken as the reference standard for our study [13,14] and demonstrate that the kFLCs Index is a valid tool to MS diagnosis [15]. These results are further improved through a re-evaluation of diagnoses adding to the statistics two cases that had not previously been diagnosed as MS.…”

Diagnostic and Prognostic Significance of Intrathecal Synthesis of Immunoglobulin Free Light Chains in Multiple Sclerosis

“…В то же время доказано, что интратекально синтезиру-ются иммуноглобулины как с каппа, так и лямб-да легкими цепями, в частности, значимая часть ОКИ IgG содержит легкие цепи лямбда [15]. Изо-лированное повышение К-СЛЦ при РС может быть обусловлено склонностью к полимеризации Л-СЛЦ.…”