Determination of Kepone dechlorination products in finfish, oysters, and crustaceans

Carver, Richard A.; Griffith, Francis D.

doi:10.1021/jf60225a005

Cited by 17 publications

(9 citation statements)

References 8 publications

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“…The volatility and solubility of 5b-hydroCLD have never been determined experimentally. From thermodynamic data, Dolfing et al (2012) have estimated that 5b-hydroCLD has a Henry's constant of 0.00284 Pa m or liquid chromatographic analysis using apolar columns (Carver and Griffith 1979;George et al 1986;Belghit et al 2015; this article, data not shown). This elution order is indeed experimental evidence that 5b-hydroCLD is more polar than CLD and so necessarily more soluble in a polar solvent like water.…”

Section: Different Physical Behaviour Of 5b-hydrocld and Cld Resultinmentioning

confidence: 93%

“…5b-Hydrochlordecone 4 (5b-hydroCLD), whose structure is identical to CLD except that one chlorine atom is replaced by a hydrogen at position 5b (Chemical Abstracts Service (CAS) numbering) and which is commercially available as an analytical standard, has been searched for and often detected in environmental matrices (soil, surface water and groundwater, sediments, plants, avian tissues and eggs, crustaceans, molluscs and fishes) from the geographical areas where CLD was applied (FWI) or unintentionally released during its manufacture (USA) (Borsetti and Roach 1978;Harless et al 1978;Stafford et al 1978;Carver and Griffith 1979;Orndorff and Colwell 1980;Coat et al 2011;Martin-Laurent et al 2014;Clostre et al 2014a, b). The current tacit assumption is that the presence of this compound is not the result of a biotic or abiotic dechlorination of CLD in these matrices but rather the consequence of its presence as an impurity, a by-product of its preparation, in the CLD released in the environment (Borsetti and Roach 1978;Cabidoche et al 2009;Coat et al 2011;Martin-Laurent et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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Natural transformation of chlordecone into 5b-hydrochlordecone in French West Indies soils: statistical evidence for investigating long-term persistence of organic pollutants

Devault

Laplanche

Pascaline³

et al. 2015

Environ Sci Pollut Res

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OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible. This is an author-deposited version published in : http://oatao.univ-toulouse.fr/ Eprints ID : 15973 Abstract Chlordecone (CLD) was an organochlorine insecticide whose previous use resulted in an extensive pollution of the environment with severe health effects and social consequences. A closely related compound, 5b-hydrochlordecone (5b-hydroCLD), has been searched for and often detected in environmental matrices from the geographical area where CLD was applied. The current consensus considered that its presence was not the result of a biotic or abiotic dechlorination of CLD in these matrices but rather the consequence of its presence as impurity (synthesis by-product) in the CLD released into the environment. The aim of the present study was to determine if and to what extent degradation of CLD into 5b-hydroCLD occurred in the field. To test this hypothesis, the ratios of 5b-hydroCLD and CLD concentrations in a dataset of 810 soils collected between 2006 and 2012 in Martinique were compared to the ratios measured in 3 samples of the CLD dust commercial formulations applied in the banana fields of French West Indies (FWI) and 1 sample of the technical-grade CLD corresponding to the active ingredient used in such formulations. Soil data were processed with a hierarchical Bayesian model to account for random measurement errors and data censoring. Any pathway of CLD transformation into 5b-hydroCLD occurring over the long term in FWI soils would indeed change the ratio of 5b-hydroCLD/ CLD compared to what it was in the initially applied formulations. Results showed a significant increase of the 5b-hydroCLD/CLD ratio in the soils-25 times greater in soil than in commercial formulations-which suggested that natural CLD transformation into 5b-hydroCLD over the long term occurred in these soils. Results from this study may impact future decisions for the remediation of the polluted areas.

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Section: Different Physical Behaviour Of 5b-hydrocld and Cld Resultinmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Natural transformation of chlordecone into 5b-hydrochlordecone in French West Indies soils: statistical evidence for investigating long-term persistence of organic pollutants

Devault

Laplanche

Pascaline³

et al. 2015

Environ Sci Pollut Res

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“…In another paper aiming at the determination of CLD dechlorination products in finfish, oysters, and crustaceans, the authors (Carver and Griffith 1979) report that the acute toxicity in mysid shrimp of CLD-1Cl is approximately equal to that of CLD, while CLD-2Cl appears to be less acutely toxic by at least an order of magnitude. The source of these data is however not specified, nor is the position of dechlorination of the compounds studied.…”

Section: Discussionmentioning

confidence: 99%

Two dechlorinated chlordecone derivatives formed by in situ chemical reduction are devoid of genotoxicity and mutagenicity and have lower proangiogenic properties compared to the parent compound

Legeay

Billat

Clere

et al. 2017

Environ Sci Pollut Res

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Chlordecone (CLD) is a chlorinated hydrocarbon insecticide, now classified as a persistent organic pollutant. Several studies have previously reported that chronic exposure to CLD leads to hepatotoxicity, neurotoxicity, raises early child development and pregnancy complications, and increases the risk of liver and prostate cancer. In situ chemical reduction (ISCR) has been identified as a possible way for the remediation of soils contaminated by CLD. In the present study, the objectives were (i) to evaluate the genotoxicity and the mutagenicity of two CLD metabolites formed by ISCR, CLD-5a-hydro, or CLD-5-hydro (5a- or 5- according to CAS nomenclature; CLD-1Cl) and tri-hydroCLD (CLD-3Cl), and (ii) to explore the angiogenic properties of these molecules. Mutagenicity and genotoxicity were investigated using the Ames's technique on Salmonella typhimurium and the in vitro micronucleus micromethod with TK6 human lymphoblastoid cells. The proangiogenic properties were evaluated on the in vitro capillary network formation of human primary endothelial cells. Like CLD, the dechlorinated derivatives of CLD studied were devoid of genotoxic and mutagenic activity. In the assay targeting angiogenic properties, significantly lower microvessel lengths formed by endothelial cells were observed for the CLD-3Cl-treated cells compared to the CLD-treated cells for two of the three tested concentrations. These results suggest that dechlorinated CLD derivatives are devoid of mutagenicity and genotoxicity and have lower proangiogenic properties than CLD.

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“…In the 1970s, Borsetti and Roach (1978) and Carver and Griffith (1979) already recommended not limiting monitoring to CLD, but also advised studying the fate of its dechlorinated products. In recent years, new analytical procedures in public surveillance programs have regularly detected a CLD-related compound, chlordecone-5b-hydro (CLD-5b-hydro) in water, soil, and plants in association with CLD.…”

Section: Introductionmentioning

confidence: 99%

Comparative fate of an organochlorine, chlordecone, and a related compound, chlordecone-5b-hydro, in soils and plants

Clostre¹,

Cattan²,

Gaude³

et al. 2015

Science of The Total Environment

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Determination of Kepone dechlorination products in finfish, oysters, and crustaceans

Cited by 17 publications

References 8 publications

Natural transformation of chlordecone into 5b-hydrochlordecone in French West Indies soils: statistical evidence for investigating long-term persistence of organic pollutants

Natural transformation of chlordecone into 5b-hydrochlordecone in French West Indies soils: statistical evidence for investigating long-term persistence of organic pollutants

Two dechlorinated chlordecone derivatives formed by in situ chemical reduction are devoid of genotoxicity and mutagenicity and have lower proangiogenic properties compared to the parent compound

Comparative fate of an organochlorine, chlordecone, and a related compound, chlordecone-5b-hydro, in soils and plants

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