Determination of isopropyl-9H-thioxanthen-9-one in packaged beverages by solid-phase extraction clean-up and liquid chromatography with tandem mass spectrometry detection

Sun, Cuilian; Chan, Sheot Harn; Lu, Dan; Lee, Hui Min Wendy; Bloodworth, Bosco Chen

doi:10.1016/j.chroma.2007.01.014

Cited by 43 publications

(22 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A few methods based on LC in combination with UV detection (Papilloud et al 2002;Sanches-Silva et al 2008a, 2008b, 2009 or even fluorescence detection have also been reported (Morlock & Schwak 2006;Sagratini et al 2008). However, LC-MS/MS has gained popularity (Sagratini et al 2006;Bagnati et al 2007;Gil-Vergara et al 2007;Sun et al 2007;Allegrone et al 2008;Gallart-Ayala et al 2008, 2011Sanches-Silva et al 2008;Shen et al 2009). A comparison between GC and LC has shown, however, that both techniques are adequate: LC gives a lower LOQ while the repeatability is comparable (Gil-Vergara et al 2007).…”

Section: Introductionmentioning

confidence: 95%

Evaluation of the migration of 15 photo-initiators from cardboard packaging into Tenax^®using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)

Houwe

Velde

Evrard

et al. 2014

Food Additives & Contaminants: Part A

View full text Add to dashboard Cite

Photo-initiators are widely used to cure ink on packaging materials used in food applications such as plastic films or cartonboards. In migration studies, food simulants are very often used to simulate food, like Tenax(®), which is the simulant for dry foodstuffs. In this paper a fast and reliable confirmation method for the determination of the following photo-initiators in Tenax(®) is described: benzophenone (BP), 4,4'-bis(diethylamino)benzophenone (DEAB), 2-chloro-9H-thioxanthen-9-one (CTX), 1-chloro-4-propoxy-9H-thioxanthen-9-one (CPTX), 2,4-diethyl-9H-thioxanthen-9-one (DETX), 2,2-dimethoxy-2-phenyl acetophenone (DMPA), 4-(dimethylamino)benzophenone (DMBP), 2-ethylanthraquinone (EA), ethyl-4-dimethylaminobenzoate (EDMAB), 1-hydroxylcyclohexyl phenyl ketone (HCPK), 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (HMMP), 2-isopropyl-9H-thioxanthen-9-one (ITX), 4-methylbenzophenone (MBP), Michler's ketone (MK), and 4-phenylbenzophenone (PBZ). After the migration study was completed, the simulant Tenax(®) was extracted using acetonitrile, followed by analysis on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Quantification was carried out using benzophenone-d10 (BP-d10) as internal standard. The presented method is validated in terms of matrix effect, specificity, linearity, recovery, precision and sensitivity, showing the method can detect all photo-initiators at very low concentrations (LOD < 0.125 µg g(-1) for all substances). Finally, the procedure was applied to real samples, proving the capabilities of the presented method.

show abstract

Section: Introductionmentioning

confidence: 95%

Evaluation of the migration of 15 photo-initiators from cardboard packaging into Tenax^®using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)

Houwe

Velde

Evrard

et al. 2014

Food Additives & Contaminants: Part A

View full text Add to dashboard Cite

show abstract

“…Regarding the migration studies in orange juice, Rodushkin and Magnusson (2005) have studied the transfer of aluminium from laminated paperboard packages and more recently ITX, a photoinitiator, has also been studied by Sagratini, Mañes, Giardiná, and Pico (2006) and Sun, Chan, Lu, Lee, and Bloodworth (2007).…”

Section: Introductionmentioning

confidence: 98%

Time-temperature study of the kinetics of migration of diphenylbutadiene from polyethylene films into aqueous foodstuffs

Sanches-Silva

Cruz

Franz

et al. 2008

Food Research International

View full text Add to dashboard Cite

“…The amendment provides an SML of 0.05 mg/kg for ethyl‐4‐dimethylaminobenzoate (EDMAB), 2‐hydroxy‐4′‐(2‐hydroxyethoxy)‐2‐methylpropiophenone (HMMP) and isopropylthioxanthenone (ITX), but if the toxicity of a compound is not yet evaluated, migration should remain below 0.01 mg/kg . Numerous studies have already been reported for the determination of photoinitiators in food matrices such as fruit juice, gazpacho, white wine, red wine, milk, yoghurt and tea . In these procedures, the foodstuffs were extracted using an organic solvent or QuEChERS (quick, easy, cheap, effective, rugged, safe).…”

Section: Introductionmentioning

confidence: 99%

Migration of 17 Photoinitiators from Printing Inks and Cardboard into Packaged Food – Results of a Belgian Market Survey

et al. 2016

View full text Add to dashboard Cite

Photoinitiators are widely used to cure ink on packaging materials used in food applications such as carton boards and can contaminate the food by migrating into the food. In this contribution, a fast and reliable confirmation method for the determination of photoinitiators in dry foodstuffs is described: benzophenone (BP), 4,4′‐bis(diethylamino)benzophenone (DEAB), 2‐chloro‐9H‐thioxanthen‐9‐one (CTX), 1‐chloro‐4‐ropoxy‐9H‐thioxanthen‐9‐one (CPTX), 2,2‐dimethoxy‐ 2‐phenyl acetophenone (DMPA), 4‐(dimethylamino)benzophenone (DMBP), 2‐ethylanthraquinone (EA), 2‐ethylhexyl‐4‐dimethylaminobenzoate (EDB), ethyl‐4‐dimethylaminobenzoate (EDMAB), 4‐hydroxybenzophenone (4‐HBP), 1‐hydroxycyclohexyl phenyl ketone (HCPK), 2‐hydroxy‐4‐methoxybenzophenone (HMBP), 2‐hydroxy‐4′‐(2‐hydroxyethoxy)‐2‐methylpropiophenone (HMMP), 2‐isopropyl‐9H‐thioxanthen‐9‐one (ITX), 4‐methylbenzophenone (MBP), 4,4′‐bis(dimethylamino)benzophenone (MK) and 4‐phenylbenzophenone (PBZ). Dry foodstuffs were extracted using acetonitrile, followed by the addition of inorganic salts to precipitate fatty residues. After filtration, the extract was analysed using ultra‐performance liquid chromatography in combination with tandem mass spectrometry (UPLC‐MS/MS). Quantification was carried out using benzophenone‐d10 (BP‐d10) as internal standard. The presented method was successfully validated in‐house. Afterwards, the procedure was applied in a marketing study, investigating 97 dry foodstuffs purchased on the Belgian market. In 89% of the samples, at least one photoinitiator was detected. The photoinitiators BP, EDMA and DMPA were most frequently found, while some photoinitiators (CPTX, DEAB, DMBP, HCPK, HMBP and MK) were never detected. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Determination of isopropyl-9H-thioxanthen-9-one in packaged beverages by solid-phase extraction clean-up and liquid chromatography with tandem mass spectrometry detection

Cited by 43 publications

References 4 publications

Evaluation of the migration of 15 photo-initiators from cardboard packaging into Tenax^®using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)

Evaluation of the migration of 15 photo-initiators from cardboard packaging into Tenax^®using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)

Time-temperature study of the kinetics of migration of diphenylbutadiene from polyethylene films into aqueous foodstuffs

Migration of 17 Photoinitiators from Printing Inks and Cardboard into Packaged Food – Results of a Belgian Market Survey

Contact Info

Product

Resources

About

Determination of isopropyl-9H-thioxanthen-9-one in packaged beverages by solid-phase extraction clean-up and liquid chromatography with tandem mass spectrometry detection

Cited by 43 publications

References 4 publications

Evaluation of the migration of 15 photo-initiators from cardboard packaging into Tenax®using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)

Evaluation of the migration of 15 photo-initiators from cardboard packaging into Tenax®using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)

Time-temperature study of the kinetics of migration of diphenylbutadiene from polyethylene films into aqueous foodstuffs

Migration of 17 Photoinitiators from Printing Inks and Cardboard into Packaged Food – Results of a Belgian Market Survey

Contact Info

Product

Resources

About

Evaluation of the migration of 15 photo-initiators from cardboard packaging into Tenax^®using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)

Evaluation of the migration of 15 photo-initiators from cardboard packaging into Tenax^®using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)