Determination of isoniazid and hydrazine by capillary electrophoresis with amperometric detection at a Pt‐particle modified carbon fiber microelectrode

A carbon paste electrode (CPE)/Cu nanowire (Cu NW)/poly(1-ethyl-3-methylimidazolium methyl sulfate) based sensor was successfully fabricated by the electro-polymerization of 1-ethyl-3-methylimidazolium methyl sulfate (EMIMS) onto the surface of Cu nanowires-modified carbon paste electrode. The morphology and chemical nature of Cu NWs were characterized by FTIR, FE-SEM, TEM, XRD techniques. The CPE/CuNWs/poly(EMIMS) showed an electrocatalytic activity toward the determination of etilefrine hydrochloride (ET-HCl) in the 0.11 M buffer solution of phosphate at pH 7.0. The CPE/CuNWs/poly (EMIMS) showed an excellent limit of detection (LOD) 2.3 μM over the linear dynamic range of 0.1 to 1.3 μM. The prepared CPE/CuNWs/poly(EMIMS) has exhibited high stability, good sensitivity, and low detection limit for the determination of ET-HCl. The validity of this advanced method was checked by applying in the blood plasma samples, with satisfactory results. This novel CPE/CuNWs/poly(EMIMS) can be an attractive material for the applications in biomedical and sensor fields.

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Genetic Algorithm Based Potential Selection in Simultaneous Voltammetric Determination of Isoniazid and Hydrazine by Using Partial Least Squares (PLS) and Artificial Neural Networks (ANNs)

Majidi

Jouyban

Asadpour‐Zeynali

2005

Electroanalysis

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The voltammetric behavior of isoniazid and hydrazine at an overoxidized polypyrrole modified glassy carbon electrode has been investigated. The obtained cyclic voltammograms showed that their oxidation peaks were overlapped and it is difficult to determine them individually from a mixture without separation. To overcome this limitation, a procedure was proposed for resolution of overlapped voltammetric signals from mixtures of isoniazid and hydrazine. In this procedure, genetic algorithm was used for the selection of potentials for partial least squares. A feed forward artificial neural network with back propagation error algorithm was used to process the nonlinear relationship between currents and concentrations of hydrazine and isoniazid. The proposed method was suitable for determination of isoniazid in pharmaceutical tablets and detection of hydrazine impurities in the same samples.

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Determination of isoniazid and hydrazine by capillary electrophoresis with amperometric detection at a Pt‐particle modified carbon fiber microelectrode

Cited by 17 publications

References 19 publications

Applications of Microelectrodes in Capillary Electrophoresis/Electrochemical Detection

Applications of Microelectrodes in Capillary Electrophoresis/Electrochemical Detection

Facile Preparation of Ionic Liquid‐coated Copper Nanowire‐modified Carbon Paste Electrode for Electrochemical Detection of Etilefrine Drug

Genetic Algorithm Based Potential Selection in Simultaneous Voltammetric Determination of Isoniazid and Hydrazine by Using Partial Least Squares (PLS) and Artificial Neural Networks (ANNs)

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