Determination of ERG(+), EZH2, NKX3.1, and SPINK‐1 subtypes to evaluate their association with clonal origin and disease progression in multifocal prostate cancer
Abstract:cause death. The criteria to establish PCa prognosis include PSA level, Gleason score, and clinical TNM stage, but these criteria still do not establish the prognosis with su cient certainty (2).Many studies have established different classi cations of PCa in molecular subtypes that can contribute to determining the prognosis, among them ETS(+) subtypes, characterized by chromosomal fusions, which cause the overexpression of ETS transcription factors. The most prevalent ETS fusion in PCa is TMPRSS2-ERG, which … Show more
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