Determination of human cone pigment density difference spectra in spatially resolved regions of the fovea

Kilbride, Paul E.; Read, John S.; Fishman, Gerald A.; Fishman, Marlene

doi:10.1016/0042-6989(83)90145-1

Cited by 41 publications

(16 citation statements)

References 17 publications

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“…[26][27][28][29] The density map of cone photopigments corresponding to the anatomical distribution of the cones was obtained in humans, 26 and the roddominant photopigment density was also estimated from the peripheral retina. 27,28 However, the recording protocols were too complicated and the bleaching topographies obtained by these methods did not have enough image quality for clinical assessment of either the cone or rod photopigments.…”

Section: Discussionmentioning

confidence: 99%

“…[18][19][20][21][22] Retinal densitometry was later used to measure the spatial and spectral distribution of the refl ectance changes by examining images obtained with either a fundus camera or by SLO, that is, by imaging fundus refl ectometry. 14,[23][24][25][26][27][28][29][30][31] These techniques allowed the investigators to map objectively and noninvasively the cones and rods as bleach-derived light refl ectance changes in both normal and diseased eyes.…”

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confidence: 99%

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Novel snapshot imaging of photoreceptor bleaching in macaque and human retinas

et al. 2010

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Novel snapshot imaging of photoreceptor bleaching in macaque and human retinas

et al. 2010

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“…Others have shown that fundus pigmentation is highly correlated with skin color [16,17,27,29]. Given the preponderance of whites in the health professions and in research in particular, most normative data are based on the white population.…”

Section: Discussionmentioning

confidence: 99%

“…All photographs were taken with the same background and flash intensity levels. Before photography, each subject was light adapted for 10 minutes to a constant background luminance of approximately ll0cd/m 2, and thus variations in fundus pigmentation were not due to differences in photoreceptor pigment optical density [16][17].…”

Section: Methodsmentioning

confidence: 99%

Fundus pigmentation and the dark-adapted electroretinogram

Wali

Leguire

1992

Doc Ophthalmol

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Dark-adapted electroretinograms were obtained over a 3.6-log range of stimulus intensities from 17 black and 15 white normal subjects. Subjects were grouped on the basis of light or dark fundus pigmentation, determined from digitized fundus photographs. B-wave amplitudes for each group were fitted by the Naka-Rushton equation, and the measures Vmax, log K, and n were determined. The luminance-response functions revealed that subjects with light fundi had larger b-wave amplitudes at all luminance levels. There was a significant difference between groups for Vmax and n but not for log K. A comparison of b-wave implicit times showed no significant difference between subjects with dark and light fundi. Ancillary tests and multiple regression analysis suggested that the relationship between Vmax and fundus pigmentation could not be attributed to age, gender, refractive error, axial length or intraocular pressure. The results have implications for the collection of normative electroretinographic data and for the interpretation of electroretinogram results.

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“…[5][6][7][8][9][10] Retinal densitometry has been used to map the function of both the normal and the diseased retina, by using either a fundus camera [11][12][13][14][15] or SLO. [16][17][18] However, the clinical applications of these techniques are limited because of technical limitations.…”

Section: Introductionmentioning

confidence: 99%

Origins of retinal intrinsic signals: A series of experiments on retinas of macaque monkeys

et al. 2009

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Diffuse flash stimuli applied to the ocular fundus evoke light reflectance decreases of the fundus illuminated with infrared observation light. This phenomenon, which is independent of the photopigment bleaching observed as an increase in the reflectance of visible light, is called intrinsic signals. Intrinsic signals, in general, are stimulus-evoked light reflectance changes of neural tissues due to metabolic changes, and they have been extensively investigated in the cerebral cortex. This noninvasive objective technique of functional imaging has good potential as a tool for the early detection of retinal dysfunction. Once the signal properties were studied in detail, however, it became apparent that the intrinsic signals observed in the retina have uniquely interesting properties of their own due to the characteristic layered structure of the retina. Experiments on anesthetized macaque monkeys are reviewed, and the possible origins of the intrinsic signals of the retina are discussed.

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Determination of human cone pigment density difference spectra in spatially resolved regions of the fovea

Cited by 41 publications

References 17 publications

Novel snapshot imaging of photoreceptor bleaching in macaque and human retinas

Novel snapshot imaging of photoreceptor bleaching in macaque and human retinas

Fundus pigmentation and the dark-adapted electroretinogram

Origins of retinal intrinsic signals: A series of experiments on retinas of macaque monkeys

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