Determination of human body burden baseline date of platinum through autopsy tissue analysis.

Vandiver, F; Duffield, F V; Yoakum, Anna M.; Bumgarner, Jacob R.; J, Morán

doi:10.1289/ehp.7615131

Cited by 14 publications

(1 citation statement)

References 4 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following the exposure of rats to Pt compounds via inhalation, the highest concentrations of Pt were found in the lungs and the kidneys 30. The analysis of the Pt content of non-occupationally exposed human autopsied tissue found the highest concentrations in the subcutaneous fat, the kidneys, the pancreas and the liver 31. In vitro permeation studies reported that most of the Pt was retained inside the skin, leading the authors to state that a Pt reservoir may form inside the skin from where Pt could be gradually released.…”

Section: Discussionmentioning

confidence: 99%

Urinary excretion of platinum from South African precious metals refinery workers

2018

View full text Add to dashboard Cite

The urinary Pt excretion of South African precious metals refinery workers reported in this study is comparable with that of seven other studies conducted in precious metals refineries and automotive catalyst plants in Europe. The Pt body burden of workers is predominantly determined by their work area, years of employment in the refineries and whether they are directly or indirectly exposed to Pt.

show abstract

Section: Discussionmentioning

confidence: 99%

Urinary excretion of platinum from South African precious metals refinery workers

2018

View full text Add to dashboard Cite

show abstract

Comparison of three different methods for measurement of tissue platinum level

Minami

Ichii

Okazaki

1995

Biol Trace Elem Res

View full text Add to dashboard Cite

We attempted to make a comparison of three methods for tissue platinum; atomic absorption spectrometry (AAS), inductively coupled plasma atomic emission spectrometry (ICP-AES), and inductively coupled plasma mass spectrometry (ICP-MS). The determination limits were 0.05 ng/mL on ICP-MS, 50 ng/mL on ICP-AES, and 200 ng/mL on AAS, and the recovery rates were 97.7 +/- 6.9% on ICP-MS, 69.0 +/- 3.0% on ICP-AES, and 102.4 +/- 4.0% on AAS, respectively. Platinum was detected by ICP-AES and ICP-MS in human vertebrae, but the level was higher by ICP-AES than by ICP-MS. In the mouse kidney treated with cisplatin, platinum was detected by ICP-MS, but not by ICP-AES. As cadmium gives the absorption peak close to platinum, cadmium was measured together with platinum by ICP-AES in the vertebrae. From these, ICP-MS is the most sensitive for measurement at tissue platinum. The sensitivity of ICP-AES looks worse for measuring the tissue platinum, and it is necessary to take care of the contaminant of metals, especially cadmium. AAS is not suitable for measurement of tissue platinum as in the vertebrae and kidneys, because platinum was not detectable by AAS.

show abstract

Accumulation of platinum in the intervertebral discs and vertebrae of ovarian tumor-bearing patients treated with cisplatin

Minami

Hashii

Tateyama

et al. 1994

Biol Trace Elem Res

View full text Add to dashboard Cite

Platinum was determined by the inductively coupled plasma mass spectrometry (ICP-MS) in the intervertebral discs and vertebrae of ovarian tumor bearing patients treated with cis-diamminedichloro-platinum (II) (cisplatin). Platinum was 0.05 ng/mL at the absolute detection limit, and platinum was undetectable in the intervertebral discs and vertebrae of human specimens without cisplatin treatments. On the other hand, platinum was detected in the intervertebral discs and vertebrae of patients administered cisplatin, and platinum concentration was at levels of 1.06-10.31 micrograms/g dry tissue in the intervertebral discs and 0.60-1.28 micrograms/g dry tissue in the vertebrae, respectively. The platinum level of intervertebral discs was 4.3-fold higher than that of the vertebrae. Thus, platinum accumulates greatly in the intervertebral discs and somewhat in the vertebrae after administering cisplatin to patients for therapy.

show abstract

Determination of human body burden baseline date of platinum through autopsy tissue analysis.

Cited by 14 publications

References 4 publications

Urinary excretion of platinum from South African precious metals refinery workers

Urinary excretion of platinum from South African precious metals refinery workers

Comparison of three different methods for measurement of tissue platinum level

Accumulation of platinum in the intervertebral discs and vertebrae of ovarian tumor-bearing patients treated with cisplatin

Contact Info

Product

Resources

About