2023
DOI: 10.3389/fphar.2022.1031790
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Determination of HMGB1 in hepatitis B virus-related acute-on-chronic liver failure patients with acute kidney injury: Early prediction and prognostic implications

Abstract: Background: Acute kidney injury (AKI) is a frequent complication in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) and is associated with high rates of mortality. We aimed to estimate serum high mobility group protein 1 (HMGB1) levels in hepatitis B virus-related acute-on-chronic liver failure patients and analyze their clinical value in the development and outcomes of Acute kidney injury.Methods: A total of 251 consecutive patients with hepatitis B virus-related acute-on-chr… Show more

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Cited by 2 publications
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“…Hepatitis B cirrhosis, triggered by the prolonged infection of hepatitis B virus, is related to AKI in cirrhotic patients. 20 , 21 For lipid and atherosclerosis, atherosclerosis has a relationship with chronic kidney disease. 22 Lipid accumulation may subsequently develop into lipotoxicity, which further induces pathological injury in proximal tubular cells.…”
Section: Discussionmentioning
confidence: 99%
“…Hepatitis B cirrhosis, triggered by the prolonged infection of hepatitis B virus, is related to AKI in cirrhotic patients. 20 , 21 For lipid and atherosclerosis, atherosclerosis has a relationship with chronic kidney disease. 22 Lipid accumulation may subsequently develop into lipotoxicity, which further induces pathological injury in proximal tubular cells.…”
Section: Discussionmentioning
confidence: 99%