Determination of hexamethylene tetramine in thermosetting moulding compounds

Abstract

Hexamethylene tetramine (hexamine) in phenol‐formaldehyde and urea‐formaldehyde moulding compounds can be determined by non‐aqueous titration in acetic acid solution with perchloric acid. Phenolic compounds may be dissolved directly in glacial acetic acid and the hexamine may be titrated. However, hexamine must first be extracted from dry urea‐formaldehyde samples with chloroform before titration as the resin interferes with the titration. Nuclear magnetic resonance spectroscopy may also be used to determine the hexamine content of the extracted solution.

Spectrophotometric and Fluorimetric Determination of Hexamine in Pure Form and Its Pharmaceutical Formulation

“…Various methods have been reported for the determination of hexamine namely, bromatometric, 2) polarographic, 3) specific gravity, 4) gravimetric, 5) GC, 6) acid-base, 7) amperometric, 8) potentiometric, 9) conductometric, 10) coulometric, 11) complexometric, 12) and 1 H-NMR. [13][14][15] While most of the methods reported in the literature are useful for the quantification of hexamine in pure form and few spectrophotometric methods [16][17][18][19][20][21][22][23][24][25][26] have been applied for the determination of hexamine in pharmaceutical preparations which suffer from disadvantages like higher detection limit, extraction process etc. A comparison of these methods is presented in Table 1.…”