Determination of Hexachlorophene in Whole Blood

Porcaro, Peter J.; Shubiak, Peter; Manowitz, Milton

doi:10.1002/jps.2600580227

Cited by 16 publications

(2 citation statements)

References 2 publications

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“…The extraction of hexachlorophane (HCP) and its estimation by gas chromatography were carried out by the methods of Porcaro, Shubiak & Manowitz (1969); Browning et al (1968); and Curley & Hawk (1971).…”

Section: Methodsmentioning

confidence: 99%

The absorption of hexachlorophane from Ultralanum ointment

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Morison

Rhodes

2006

British Journal of Dermatology

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SUMMARY The application of Ultralanum ointment to adult skin cases has produced levels of hexachlorophane in the plasma comparable with those found in infants who have undergone whole‐body washing with hexachlorophane solutions. Clinical evidence of toxicity was not observed, but it is felt that the value of hexachlorophane in topical steroid preparations should be re‐appraised, particularly for long‐term treatment of large eczematous areas.

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Section: Methodsmentioning

confidence: 99%

The absorption of hexachlorophane from Ultralanum ointment

Bye

Morison

Rhodes

2006

British Journal of Dermatology

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“…Hexachlorophene (HCP) is an antimicrobial agent, which was probably used in soaps, liquid detergents, cosmetics, and plant fungicides and pesticides [1]. However, when HCP is absorbed too much, it can lead to nervous system disturbance, central system inhibition, symptoms such as loss of consciousness, respiratory inhibition and so on [2][3][4]. HCP may be found in cosmetics due to the production conditions of cosmetic raw materials, the production process, and improper storage of cosmetics.…”

Section: Introductionmentioning

confidence: 99%

Determination of hexachlorophene in cosmetics by capillary electrophoresis compared with high performance liquid chromatography

Gao

Huitao

et al. 2020

AChrom

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Abstract A simple capillary electrophoresis (CE) method with ultraviolet (UV) detection was developed for the determination of hexachlorophene (HCP) in cosmetics. Separation conditions were obtained in 20 mM Na2B4O7, 10% MeOH (pH 9.20), with 25 kV applied voltage and UV detection at 208 nm. Under the selected conditions, electrophoretic analysis was completed in about 4 min, with limit of detection (LOD) of 0.06 µg·mL−1 for HCP. The method was successfully applied to determine HCP in three kinds of cosmetics with relative standard deviations (RSD) of 0.52–3.02% and recoveries from 90.0 to 96.4% for the spiked samples. The results indicated that the proposed method was reliable. Comparative experiments were also carried out with high-performance liquid chromatography (HPLC)-UV method described in National Standards of People's Republic of China. The validation results of the two methods are comparable, but the proposed CE method is simple, rapid, which makes separation and analyte quantification in shorter time with much less reagent consumption.

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