Determination of Heavy Metal Levels and Health Risk Assessment of Raw Cow Milk in Guelma Region, Algeria

Boudebbouz, Ali; Boudalia, Sofiane; Bousbia, Aissam; Gueroui, Yassine; Boussadia, Meriem Imen; Chelaghmia, Mohamed Lyamine; Zebsa, Rabah; Affoune, Abed Mohamed; Symeon, George

doi:10.1007/s12011-022-03308-1

Cited by 22 publications

(11 citation statements)

References 78 publications

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“…The level of Cu was recorded in the meat of cows followed by buffalo and goat, respectively, in polluted compared to non-polluted areas. The cow’s meat ranging from 0.0136 to 36 mg L −1, and exceeds the permissible level 0.01 mg L −1 set by IDF, 1979 world., reported in various studies 53 . The current work revealed a higher level of Cr in raw meat of buffalo, cows, and goats grazing in the polluted areas compared to the controlled areas, an exceeded the permissible value set by IDF.…”

Section: Discussionmentioning

confidence: 90%

“…Areas and Cd concentrations in raw buffalo and cow meat exceeded the permissible limit set by the International Dairy Federation 1979. It is the most acceptable limit for Cd in raw meat 53 .…”

Section: Discussionmentioning

confidence: 99%

“…They reported the Zn concentration was within permissible limits and far below that of current work. The contaminated heavy metals in fodder crops are used as feed and contaminate animal feed 53 .…”

Section: Discussionmentioning

confidence: 99%

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DNA damage in inhabitants exposed to heavy metals near Hudiara drain, Lahore, Pakistan

Jadoon,

Ali,

Sami

et al. 2024

Sci Rep

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The current study was conducted on the inhabitants living in the area adjacent to the Hudiara drain using bore water and vegetables adjacent to the Hudiara drain. Toxic heavy metals badly affect human health because of industrial environmental contamination. Particularly hundreds of millions of individuals globally have faced the consequences of consuming water and food tainted with pollutants. Concentrations of heavy metals in human blood were elevated in Hudiara drainings in Lahore city, Pakistan, due to highly polluted industrial effluents. The study determined the health effects of high levels of heavy metals (Cd, Cu, Zn, Fe, Pb, Ni, Hg, Cr) on residents of the Hudiara draining area, including serum MDA, 8-Isoprostane, 8-hydroxyguanosine, and creatinine levels. An absorption spectrophotometer was used to determine heavy metals in wate water, drinking water, soil, plants and human beings blood sampleas and ELISA kits were used to assess the level of 8-hydroxyguanosine, MDA, 8-Isoprostane in plasma serum creatinine level. Waste water samples, irrigation water samples, drinking water samples, Soil samples, Plants samples and blood specimens of adult of different weights and ages were collected from the polluted area of the Hudiara drain (Laloo and Mohanwal), and control samples were obtained from the unpolluted site Sheiikhpura, 60 km away from the site. Toxic heavy metals in blood damage the cell membrane and DNA structures, increasing the 8-hydroxyguanosine, MDA, creatinine, and 8-Isoprostane. Toxic metals contaminated bore water and vegetables, resulting in increased levels of creatinine, MDA, Isoprostane, and 8-hydroxy-2-guanosine in the blood of inhabitants from the adjacent area Hudiara drain compared to the control group. In addition,. This study also investigated heavy metal concentrations in meat and milk samples from buffaloes, cows, and goats. In meat, cow samples showed the highest Cd, Cu, Fe and Mn concentrations. In milk also, cows exhibited elevated Cu and Fe levels compared to goats. The results highlight species-specific variations in heavy metal accumulation, emphasizing the need for targeted monitoring to address potential health risks. The significant difference between the two groups i.e., the control group and the affected group, in all traits of the respondents (weight, age, heavy metal values MDA, 8-Isoprostane, 8-hydroxyguaniosine, and serum creatinine level). Pearson’s correlation coefficient was calculated. The study has shown that the level of serum MDA, 8-Isoprostane, 8-hydroxyguaniosine, or creatinine has not significantly correlated with age, so it is independent of age. This study has proved that in Pakistan, the selected area of Lahore in the villages of Laloo and Mohanwal, excess of heavy metals in the human body damages the DNA and increases the level of 8-Isoprostane, MDA, creatinine, and 8-hydroxyguaniosine. As a result, National and international cooperation must take major steps to control exposure to heavy metals.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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DNA damage in inhabitants exposed to heavy metals near Hudiara drain, Lahore, Pakistan

Jadoon,

Ali,

Sami

et al. 2024

Sci Rep

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“…The escalating human activities contribute to a drastic increase in heavy metal addition to the environment, posing a continuous threat to livestock through water and soil pollution ( Maurya et al, 2019 ; Ghazzal et al, 2022 ). The persistent exposure to these contaminants results in adverse health effects in livestock ( Boudebbouz et al, 2023 ; Akbar et al, 2024 ). Additionally, the transfer of heavy metals from animals to humans through the food chain raises concerns about food safety and public health ( Aftab et al, 2023 ; Noor et al, 2024 ).…”

Section: Introductionmentioning

confidence: 99%

Emerging insights into the impacts of heavy metals exposure on health, reproductive and productive performance of livestock

Afzal,

Mahreen

2024

Front. Pharmacol.

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Heavy metals, common environmental pollutants with widespread distribution hazards and several health problems linked to them are distinguished from other toxic compounds by their bioaccumulation in living organisms. They pollute the food chain and threaten the health of animals. Biologically, heavy metals exhibit both beneficial and harmful effects. Certain essential heavy metals such as Co, Mn, Se, Zn, and Mg play crucial roles in vital physiological processes in trace amounts, while others like As, Pb, Hg, Cd, and Cu are widely recognized for their toxic properties. Regardless of their physiological functions, an excess intake of all heavy metals beyond the tolerance limit can lead to toxicity. Animals face exposure to heavy metals through contaminated feed and water, primarily as a result of anthropogenic environmental pollution. After ingestion heavy metals persist in the body for an extended duration and the nature of exposure dictates whether they induce acute or chronic, clinical or subclinical, or subtle toxicities. The toxic effects of metals lead to disruption of cellular homeostasis through the generation of free radicals that develop oxidative stress. In cases of acute heavy metal poisoning, characteristic clinical symptoms may arise, potentially culminating in the death of animals with corresponding necropsy findings. Chronic toxicities manifest as a decline in overall body condition scoring and a decrease in the production potential of animals. Elevated heavy metal levels in consumable animal products raise public health concerns. Timely diagnosis, targeted antidotes, and management strategies can significantly mitigate heavy metal impact on livestock health, productivity, and reproductive performance.

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“…Milk is a widely consumed food, and its contamination with lead and cadmium has been reported in the literature (Feizi et al 2020;Boudebbouz et al 2022). Thus, simple, precise, and accurate analytical methods are required to quantify both metals in food.…”

Section: Introductionmentioning

confidence: 99%

Determination of Lead and Cadmium in Non-mineralized Raw Milk Samples Employing Extraction with Magnetic Restricted Access Carbon Nanotubes Followed by FAAS Analysis

et al. 2023

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Lead and cadmium were determined in non-mineralized raw milk samples employing dispersive solid phase extraction with magnetic restricted access carbon nanotubes (M-RACNTs), followed by ame atomic absorption spectrometry analysis. M-RACNTs were obtained by modifying carbon nanotubes (CNTs) with magnetite nanoparticles and then covering with a chemically crosslinked bovine serum albumin (BSA) external layer. The M-RACNTs particles were very e cient to capture the metals and exclude proteins from the milk, being easily separated from the sample using a neodymium magnet. The extraction parameters were appraised by multivariate optimization (factorial design and Doehlert matrix). The method was validated and proved to be robust for small variations, simple, fast, sensitive and selective. The determination coe cient and limit of quanti cation were 0.998 and 10 µg L -1 , respectively, for both Pb 2+ and Cd 2+ ions. The developed method was able to determine both metals in concentrations below the maximum residue limits (20 and 50 µg L -1 for Pb 2+ and Cd + , respectively, in Brazil), demonstrating that M-RACNTs are promising materials for metal extraction in protein-rich samples, without the need for mineralization procedures.Recently, the use of smart sorbents to extract metals from complex samples has increased, mainly due to the simplicity and security of this procedure. Carbon nanotubes (CNTs) can be an important sorbent in this case, due to their high adsorptive capacity (Herbst et al. 2004;Barbosa et al. 2015). However, the use of commercial CNTs is limited in the preparation of biological samples, given that proteins can bind to the

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Determination of Heavy Metal Levels and Health Risk Assessment of Raw Cow Milk in Guelma Region, Algeria

Cited by 22 publications

References 78 publications

DNA damage in inhabitants exposed to heavy metals near Hudiara drain, Lahore, Pakistan

DNA damage in inhabitants exposed to heavy metals near Hudiara drain, Lahore, Pakistan

Emerging insights into the impacts of heavy metals exposure on health, reproductive and productive performance of livestock

Determination of Lead and Cadmium in Non-mineralized Raw Milk Samples Employing Extraction with Magnetic Restricted Access Carbon Nanotubes Followed by FAAS Analysis

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